Nucleosome organization of mouse embryos during pre-implantation development

• Published in: Scientific reports Vol. 15; no. 1; pp. 21894 - 17
• Main Authors: Zeng, Jitao, Tu, Xiaojuan, Qu, Siming, Chen, Xichan, Wang, Ying, Liu, Xiaona, Kang, Enchuan, Tian, Yi, Xiang, Qianming, Lai, Binbin, Gao, Weiwu, Ni, Bing, He, Wei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2025; Nature Portfolio
• Subjects: 631/136; 631/136/2086; 631/208; 631/208/177; Animals; Blastocyst - metabolism; Chromatin - metabolism; Chromatin Assembly and Disassembly; Chromatin organization; Embryo, Mammalian - metabolism; Embryonic Development - genetics; Embryos; Female; Gene Expression Regulation, Developmental; H3K4me3; Histones - metabolism; Humanities and Social Sciences; Male; Mice; multidisciplinary; Nucleosome position; Nucleosomes - genetics; Nucleosomes - metabolism; Science; Science (multidisciplinary); scMNase-seq; Transcription Initiation Site; Chromatin organization; Nucleosome position; Embryos; H3K4me3; scMNase-seq

Sexual reproduction begins with sperm–oocyte fusion to form a zygote, where chromatin undergoes dramatic reorganization to establish totipotency. Although nucleosomes- the basic units of eukaryotic chromatin and key epigenetic regulators- are extensively remodeled during early embryogenesis, their d...