Ginger: a representative material of herb-derived exosome-like nanoparticles

Edible plant-derived exosome-like nanoparticles (PELNs) provide numerous benefits, including high yield, low cost, ethical compatibility, and multiple health benefits, which enable them to address technical constraints associated with mammalian nanoparticles. Herbs, known for their abundant bioactiv...

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Published inFrontiers in nutrition (Lausanne) Vol. 10; p. 1223349
Main Authors Zhu, He, He, Wenxi
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 13.07.2023
Subjects
exosome
ginger
herb
nanoparticle
Nutrition
traditional Chinese medicine
nanoparticle
traditional Chinese medicine
exosome
herb
ginger
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Abstract Edible plant-derived exosome-like nanoparticles (PELNs) provide numerous benefits, including high yield, low cost, ethical compatibility, and multiple health benefits, which enable them to address technical constraints associated with mammalian nanoparticles. Herbs, known for their abundant bioactive components, are considered the primary source of natural medicines within the plant kingdom. Recently, a number of herbaceous sources have been investigated for the isolation and functionality of exosome-like nanoparticles (ELNs). However, they are commonly referred to as PELNs, and their distinct pharmacological properties are overlooked. In this review, these herb-derived ELNs are designated as HELNs, a novel herbal product that may also exhibit superior pharmacological activity compared to other types of PELNs. Among the documented HELNs, ginger-derived exosome-like nanoparticles (GELNs) are the most extensively studied. This review employs GELNs as an exemplar to delineate the process of extraction and purification, together with their physical and biochemical characteristics and therapeutic potential. The aim of this review is to promote the development and application of HELNs, and future research is encouraged to uncover their additional properties, extending beyond those of GELNs.
AbstractList Edible plant-derived exosome-like nanoparticles (PELNs) provide numerous benefits, including high yield, low cost, ethical compatibility, and multiple health benefits, which enable them to address technical constraints associated with mammalian nanoparticles. Herbs, known for their abundant bioactive components, are considered the primary source of natural medicines within the plant kingdom. Recently, a number of herbaceous sources have been investigated for the isolation and functionality of exosome-like nanoparticles (ELNs). However, they are commonly referred to as PELNs, and their distinct pharmacological properties are overlooked. In this review, these herb-derived ELNs are designated as HELNs, a novel herbal product that may also exhibit superior pharmacological activity compared to other types of PELNs. Among the documented HELNs, ginger-derived exosome-like nanoparticles (GELNs) are the most extensively studied. This review employs GELNs as an exemplar to delineate the process of extraction and purification, together with their physical and biochemical characteristics and therapeutic potential. The aim of this review is to promote the development and application of HELNs, and future research is encouraged to uncover their additional properties, extending beyond those of GELNs.Edible plant-derived exosome-like nanoparticles (PELNs) provide numerous benefits, including high yield, low cost, ethical compatibility, and multiple health benefits, which enable them to address technical constraints associated with mammalian nanoparticles. Herbs, known for their abundant bioactive components, are considered the primary source of natural medicines within the plant kingdom. Recently, a number of herbaceous sources have been investigated for the isolation and functionality of exosome-like nanoparticles (ELNs). However, they are commonly referred to as PELNs, and their distinct pharmacological properties are overlooked. In this review, these herb-derived ELNs are designated as HELNs, a novel herbal product that may also exhibit superior pharmacological activity compared to other types of PELNs. Among the documented HELNs, ginger-derived exosome-like nanoparticles (GELNs) are the most extensively studied. This review employs GELNs as an exemplar to delineate the process of extraction and purification, together with their physical and biochemical characteristics and therapeutic potential. The aim of this review is to promote the development and application of HELNs, and future research is encouraged to uncover their additional properties, extending beyond those of GELNs.
Edible plant-derived exosome-like nanoparticles (PELNs) provide numerous benefits, including high yield, low cost, ethical compatibility, and multiple health benefits, which enable them to address technical constraints associated with mammalian nanoparticles. Herbs, known for their abundant bioactive components, are considered the primary source of natural medicines within the plant kingdom. Recently, a number of herbaceous sources have been investigated for the isolation and functionality of exosome-like nanoparticles (ELNs). However, they are commonly referred to as PELNs, and their distinct pharmacological properties are overlooked. In this review, these herb-derived ELNs are designated as HELNs, a novel herbal product that may also exhibit superior pharmacological activity compared to other types of PELNs. Among the documented HELNs, ginger-derived exosome-like nanoparticles (GELNs) are the most extensively studied. This review employs GELNs as an exemplar to delineate the process of extraction and purification, together with their physical and biochemical characteristics and therapeutic potential. The aim of this review is to promote the development and application of HELNs, and future research is encouraged to uncover their additional properties, extending beyond those of GELNs.
Author He, Wenxi
Zhu, He
AuthorAffiliation 2 NHC Key Laboratory of Respiratory Diseases, the Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei , China
1 Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei , China
AuthorAffiliation_xml – name: 2 NHC Key Laboratory of Respiratory Diseases, the Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei , China
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Cites_doi 10.1038/s41598-018-32953-7
10.1038/mt.2016.159
10.1208/s12249-021-02087-7
10.1016/j.chom.2018.10.001
10.1016/j.bbcan.2017.10.001
10.1080/10408391003698669
10.1146/annurev-cellbio-101512-122326
10.1021/acs.chemrev.5b00046
10.1016/j.febslet.2009.09.041
10.1371/journal.pone.0199438
10.1080/21688370.2015.1134415
10.1016/j.bbrc.2009.02.160
10.1016/j.phrs.2022.106472
10.3402/jev.v4.27031
10.1038/s41565-017-0012-z
10.1038/srep23978
10.1038/s41467-020-15889-3
10.1016/j.heliyon.2019.e01989
10.1038/mt.2013.64
10.1021/acsomega.1c02162
10.1038/s41467-021-24384-2
10.1016/j.jconrel.2023.01.071
10.1186/s12943-019-0985-3
10.1111/jipb.13181
10.2147/IJN.S394133
10.3390/molecules21040482
10.1080/10408398209527343
10.4314/tjpr.v12i2.19
10.1155/2018/8545347
10.1002/mnfr.201300729
10.1080/10837450.2023.2202242
10.1002/adma.202005709
10.1038/nrm.2017.125
10.1080/10408398.2023.2204375
10.1016/0092-8674(83)90040-5
10.1371/journal.pntd.0009423
10.1016/j.suc.2019.08.001
10.1186/1471-2164-14-319
10.21769/BioProtoc.3969
10.1093/jxb/erx355
10.1016/j.jconrel.2016.06.017
10.7150/thno.52570
10.3390/molecules23081844
10.1080/07853890.2022.2031274
10.1038/mt.2015.188
10.1038/s41569-018-0064-2
10.1016/j.addr.2021.114108
10.3390/nu13031026
10.3402/jev.v4.28713
10.1016/j.jnutbio.2020.108486
10.1038/aps.2017.178
10.3390/nu13051686
10.3390/biom9100551
10.2217/nnm-2017-0196
10.1038/srep17319
10.1002/advs.202003505
10.1158/0008-5472.CAN-14-3095
10.3390/biom11010087
10.1021/acs.jafc.1c07306
10.1016/j.jep.2017.12.019
10.1007/s11427-018-9438-y
10.1186/s12951-022-01421-w
10.1002/biof.1808
10.1039/D2NR07018A
10.3390/biomedicines10061352
10.1186/s12951-023-01919-x
10.1210/er.2009-0013
10.1002/mnfr.202200142
10.1016/j.biomaterials.2016.06.018
10.1186/s12951-022-01755-5
10.1016/j.biomaterials.2021.121178
10.3389/fbioe.2022.1023700
10.21769/BioProtoc.3685
10.1016/S0021-9258(18)64849-5
10.3402/jev.v4.29509
10.7150/thno.52558
10.1002/jev2.12182
10.1111/1750-3841.15787
10.1142/S0192415X22500410
10.1126/science.aau6977
10.1016/j.taap.2021.115425
10.1038/s41598-020-61358-8
10.7150/thno.18133
10.1152/japplphysiol.00914.2018
10.1039/C6AN00892E
10.1038/aps.2017.12
10.3390/molecules27238184
10.1016/j.ajps.2021.05.006
10.7150/thno.27608
10.1038/s41423-021-00740-6
10.1002/ptr.6362
10.1016/j.jprot.2010.06.006
10.1080/20013078.2018.1535750
10.4103/abr.abr_114_18
10.21769/BioProtoc.3390
10.3390/antiox10121881
10.3389/fendo.2020.00267
10.3390/v11010010
10.7150/thno.62514
10.1021/acs.molpharmaceut.9b00246
10.1016/j.jnutbio.2015.08.025
10.1016/j.biomaterials.2020.120467
10.3390/ma13143066
10.1016/j.phytochem.2015.07.012
10.1016/j.pharmthera.2017.02.020
10.1016/j.isci.2020.100869
10.1016/j.nut.2019.04.007
10.1016/j.ymthe.2021.05.005
10.1007/978-1-4939-2550-6_15
10.3390/ph14060571
10.1016/j.ymthe.2020.11.030
10.1016/S0092-8674(04)00045-5
10.1016/j.isci.2019.10.032
10.1039/D1NR06015E
10.1016/j.immuni.2016.02.015
10.1080/08820139.2021.1891094
10.3390/biom10020291
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Keywords nanoparticle
traditional Chinese medicine
exosome
herb
ginger
Language English
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Edited by: Tanima Bhattacharya, Chungnam National University, Republic of Korea
Reviewed by: Hitesh Chopra, Chitkara University, India; Pooja Mittal, RIMT University, India; Kanokwan Sansanaphongpricha, National Science and Technology Development Agency (NSTDA), Thailand; Sayan Ganguly, University of Waterloo, Canada
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References Ferrucci (ref99) 2018; 15
Xie (ref77) 2019; 18
Honary (ref75) 2013; 12
Bhattacharjee (ref76) 2016; 235
Bartel (ref85) 2004; 116
Rasmussen (ref74) 2020; 11
Huang (ref97) 2021; 18
Wang (ref113) 2015; 75
Regente (ref37) 2017; 68
Li (ref116) 2016; 21
Mu (ref14) 2014; 58
Chen (ref27) 2023; 21
Wu (ref108) 2021; 269
Luan (ref6) 2017; 38
Kim (ref115) 2022; 17
Takakura (ref26) 2022; 10
Suharta (ref32) 2021; 86
Kumar (ref44) 2021; 11
Wynn (ref96) 2016; 44
Liu (ref31) 2023
Zu (ref38) 2021; 279
Linares (ref70) 2015; 4
Sarvarian (ref78) 2022; 51
Li (ref68) 2017; 7
Salehi (ref34) 2019; 9
Chang (ref73) 2018; 13
Mathieu (ref87) 2021; 12
Lee (ref94) 2009; 382
Wu (ref24) 2022; 27
Huang (ref63) 2021; 63
Ou (ref40) 2023; 21
van Niel (ref3) 2018; 19
Konoshenko (ref65) 2018; 2018
Suresh (ref41) 2021; 6
Sung (ref57) 2020; 10
Semwal (ref54) 2015; 117
Baliga (ref53) 2011; 51
Liu (ref82) 2022; 20
Flynn (ref101) 2019; 99
Rahmani (ref88) 2014; 6
Saw (ref112) 2020; 63
Sung (ref58) 2019; 9
Dad (ref110) 2021; 29
Zhuang (ref48) 2015; 4
Man (ref50) 2021; 22
Vechetti (ref1) 2019; 127
Bjorklund (ref92) 2019; 66
Teng (ref2) 2020; 8
Lashgari (ref102) 2022; 48
Seo (ref36) 2023; 15
Pattni (ref111) 2015; 115
Kalarikkal (ref15) 2021; 414
Zhang (ref47) 2016; 24
Cong (ref12) 2022; 182
Hasani (ref89) 2019; 33
Aramaki (ref79) 2020; 13
Wang (ref19) 2023; 18
Wang (ref49) 2021; 13
Colombo (ref80) 2014; 30
Khan (ref100) 2020; 11
Del Pozo-Acebo (ref18) 2022; 185
Mao (ref43) 2021; 13
Long (ref56) 2021; 11
Weng (ref72) 2016; 141
Witwer (ref117) 2021; 10
Yu (ref8) 2022; 10
Zhang (ref107) 2021; 33
Yin (ref22) 2022; 70
Bischoff-Kont (ref91) 2021; 14
Livshits (ref64) 2015; 5
Rahimi Ghiasi (ref17) 2018; 7
Zhang (ref25) 2016; 101
Greening (ref66) 2015; 1295
Pi (ref69) 2018; 13
Kawamoto (ref95) 2016; 27
Kiyama (ref52) 2020; 86
Zhuang (ref109) 2016; 24
Durazzo (ref35) 2018; 23
Liang (ref106) 2021; 11
Kalarikkal (ref45) 2020; 10
Sanchez (ref5) 2021; 13
Sundaram (ref28) 2020; 23
Anusha (ref11) 2022; 66
Teng (ref42) 2021; 29
Kalluri (ref9) 2020; 367
Kwaifa (ref98) 2020; 10
Chen (ref23) 2019; 16
Sundaram (ref61) 2019; 21
Ezzat (ref93) 2018; 214
Govindarajan (ref55) 1982; 17
Pan (ref4) 1983; 33
Ju (ref16) 2013; 21
El-Sayed (ref33) 2019; 5
Hwang (ref39) 2023; 355
Li (ref83) 2018; 39
Zhang (ref46) 2017; 12
Zhang (ref62) 2016; 4
Perut (ref21) 2021; 11
Fernandes (ref105) 2022; 54
Barile (ref7) 2017; 174
Teng (ref29) 2018; 24
Beck (ref90) 2009; 30
Regente (ref10) 2009; 583
Lobb (ref67) 2015; 4
Li (ref30) 2018; 8
Mathivanan (ref81) 2010; 73
Folch (ref84) 1957; 226
Kumar (ref20) 2022; 12
Barzin (ref59) 2023; 28
Wang (ref13) 2018; 8
Kim (ref60) 2021; 10
Abd El Wahab (ref51) 2021; 15
Thery (ref118) 2018; 7
Van Belleghem (ref103) 2018; 11
Rider (ref71) 2016; 6
Lai (ref104) 2022; 50
Huang (ref86) 2013; 14
Wu (ref114) 2017; 1868
References_xml – volume: 8
  start-page: 14644
  year: 2018
  ident: ref30
  article-title: Arrowtail RNA for ligand display on ginger exosome-like Nanovesicles to systemic deliver siRNA for Cancer suppression
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-32953-7
– volume: 24
  start-page: 1783
  year: 2016
  ident: ref47
  article-title: Edible ginger-derived Nano-lipids loaded with doxorubicin as a novel drug-delivery approach for Colon Cancer therapy
  publication-title: Mol Ther J Am Soc Gene Ther
  doi: 10.1038/mt.2016.159
– volume: 22
  start-page: 206
  year: 2021
  ident: ref50
  article-title: The study of ginger-derived extracellular vesicles as a natural nanoscale drug carrier and their intestinal absorption in rats
  publication-title: AAPS PharmSciTech
  doi: 10.1208/s12249-021-02087-7
– volume: 24
  start-page: 637
  year: 2018
  ident: ref29
  article-title: Plant-derived Exosomal MicroRNAs shape the gut microbiota
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2018.10.001
– volume: 1868
  start-page: 538
  year: 2017
  ident: ref114
  article-title: Extracellular vesicles as emerging targets in cancer: recent development from bench to bedside
  publication-title: Biochim Biophys Acta Rev Cancer
  doi: 10.1016/j.bbcan.2017.10.001
– volume: 51
  start-page: 499
  year: 2011
  ident: ref53
  article-title: Update on the chemopreventive effects of ginger and its phytochemicals
  publication-title: Crit Rev Food Sci Nutr
  doi: 10.1080/10408391003698669
– volume: 30
  start-page: 255
  year: 2014
  ident: ref80
  article-title: Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles
  publication-title: Annu Rev Cell Dev Biol
  doi: 10.1146/annurev-cellbio-101512-122326
– volume: 115
  start-page: 10938
  year: 2015
  ident: ref111
  article-title: New developments in liposomal drug delivery
  publication-title: Chem Rev
  doi: 10.1021/acs.chemrev.5b00046
– volume: 583
  start-page: 3363
  year: 2009
  ident: ref10
  article-title: Vesicular fractions of sunflower apoplastic fluids are associated with potential exosome marker proteins
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2009.09.041
– volume: 13
  start-page: e0199438
  year: 2018
  ident: ref73
  article-title: Exosome purification based on PEG-coated Fe3O4 nanoparticles
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0199438
– volume: 4
  start-page: e1134415
  year: 2016
  ident: ref62
  article-title: Plant derived edible nanoparticles as a new therapeutic approach against diseases
  publication-title: Tissue Barriers
  doi: 10.1080/21688370.2015.1134415
– volume: 382
  start-page: 134
  year: 2009
  ident: ref94
  article-title: 6-Gingerol inhibits ROS and iNOS through the suppression of PKC-alpha and NF-kappaB pathways in lipopolysaccharide-stimulated mouse macrophages
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2009.02.160
– volume: 185
  start-page: 106472
  year: 2022
  ident: ref18
  article-title: Therapeutic potential of broccoli-derived extracellular vesicles as nanocarriers of exogenous miRNAs
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2022.106472
– volume: 4
  start-page: 27031
  year: 2015
  ident: ref67
  article-title: Optimized exosome isolation protocol for cell culture supernatant and human plasma
  publication-title: J Extracell Vesicles
  doi: 10.3402/jev.v4.27031
– volume: 13
  start-page: 82
  year: 2018
  ident: ref69
  article-title: Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression
  publication-title: Nat Nanotechnol
  doi: 10.1038/s41565-017-0012-z
– volume: 6
  start-page: 23978
  year: 2016
  ident: ref71
  article-title: ExtraPEG: a polyethylene glycol-based method for enrichment of extracellular vesicles
  publication-title: Sci Rep
  doi: 10.1038/srep23978
– volume: 11
  start-page: 2337
  year: 2020
  ident: ref74
  article-title: Size and surface charge characterization of nanoparticles with a salt gradient
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-15889-3
– volume: 5
  start-page: e01989
  year: 2019
  ident: ref33
  article-title: Potential application of herbs and spices and their effects in functional dairy products
  publication-title: Heliyon
  doi: 10.1016/j.heliyon.2019.e01989
– volume: 21
  start-page: 1345
  year: 2013
  ident: ref16
  article-title: Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis
  publication-title: Mol Ther J Am Soc Gene Ther
  doi: 10.1038/mt.2013.64
– volume: 6
  start-page: 17635
  year: 2021
  ident: ref41
  article-title: Low pH-based method to increase the yield of plant-derived nanoparticles from fresh ginger rhizomes
  publication-title: ACS Omega
  doi: 10.1021/acsomega.1c02162
– volume: 12
  start-page: 4389
  year: 2021
  ident: ref87
  article-title: Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9
  publication-title: Nat Commun
  doi: 10.1038/s41467-021-24384-2
– volume: 355
  start-page: 184
  year: 2023
  ident: ref39
  article-title: Yam-derived exosome-like nanovesicles stimulate osteoblast formation and prevent osteoporosis in mice
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2023.01.071
– volume: 18
  start-page: 83
  year: 2019
  ident: ref77
  article-title: The role of extracellular vesicles from different origin in the microenvironment of head and neck cancers
  publication-title: Mol Cancer
  doi: 10.1186/s12943-019-0985-3
– volume: 63
  start-page: 2020
  year: 2021
  ident: ref63
  article-title: Effective methods for isolation and purification of extracellular vesicles from plants
  publication-title: J Integr Plant Biol
  doi: 10.1111/jipb.13181
– volume: 18
  start-page: 2431
  year: 2023
  ident: ref19
  article-title: Selenium biofortification enhanced miR167a expression in broccoli extracellular vesicles inducing apoptosis in human pancreatic Cancer cells by targeting IRS1
  publication-title: Int J Nanomedicine
  doi: 10.2147/IJN.S394133
– volume: 21
  start-page: 482
  year: 2016
  ident: ref116
  article-title: Distinguishing Astragalus mongholicus and its planting soil samples from different regions by ICP-AES
  publication-title: Molecules
  doi: 10.3390/molecules21040482
– volume: 17
  start-page: 1
  year: 1982
  ident: ref55
  article-title: Ginger--chemistry, technology, and quality evaluation: part 1
  publication-title: Crit Rev Food Sci Nutr
  doi: 10.1080/10408398209527343
– volume: 12
  start-page: 255
  year: 2013
  ident: ref75
  article-title: Effect of zeta potential on the properties of Nano-drug delivery systems - a review (part 1)
  publication-title: Trop J Pharm Res
  doi: 10.4314/tjpr.v12i2.19
– volume: 2018
  start-page: 1
  year: 2018
  ident: ref65
  article-title: Isolation of extracellular vesicles: general methodologies and latest trends
  publication-title: Biomed Res Int
  doi: 10.1155/2018/8545347
– volume: 58
  start-page: 1561
  year: 2014
  ident: ref14
  article-title: Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles
  publication-title: Mol Nutr Food Res
  doi: 10.1002/mnfr.201300729
– volume: 28
  start-page: 383
  year: 2023
  ident: ref59
  article-title: Application of plant-derived exosome-like nanoparticles in drug delivery
  publication-title: Pharm Dev Technol
  doi: 10.1080/10837450.2023.2202242
– volume: 33
  start-page: e2005709
  year: 2021
  ident: ref107
  article-title: Engineered extracellular vesicles for Cancer therapy
  publication-title: Adv Mater
  doi: 10.1002/adma.202005709
– volume: 19
  start-page: 213
  year: 2018
  ident: ref3
  article-title: Shedding light on the cell biology of extracellular vesicles
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm.2017.125
– start-page: 1
  year: 2023
  ident: ref31
  article-title: Plant-derived nanoparticles and plant virus nanoparticles: bioactivity, health management, and delivery potential
  publication-title: Crit Rev Food Sci Nutr
  doi: 10.1080/10408398.2023.2204375
– volume: 33
  start-page: 967
  year: 1983
  ident: ref4
  article-title: Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor
  publication-title: Cells
  doi: 10.1016/0092-8674(83)90040-5
– volume: 15
  start-page: e0009423
  year: 2021
  ident: ref51
  article-title: Ginger (Zingiber Officinale)-derived nanoparticles in Schistosoma mansoni infected mice: Hepatoprotective and enhancer of etiological treatment
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0009423
– volume: 99
  start-page: 1051
  year: 2019
  ident: ref101
  article-title: Inflammatory bowel disease presentation and diagnosis
  publication-title: Surg Clin North Am
  doi: 10.1016/j.suc.2019.08.001
– volume: 14
  start-page: 319
  year: 2013
  ident: ref86
  article-title: Characterization of human plasma-derived exosomal RNAs by deep sequencing
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-14-319
– volume: 11
  start-page: e3969
  year: 2021
  ident: ref56
  article-title: Atomic force microscopy to characterize ginger lipid-derived nanoparticles (GLDNP)
  publication-title: Bio-protocol
  doi: 10.21769/BioProtoc.3969
– volume: 68
  start-page: 5485
  year: 2017
  ident: ref37
  article-title: Plant extracellular vesicles are incorporated by a fungal pathogen and inhibit its growth
  publication-title: J Exp Bot
  doi: 10.1093/jxb/erx355
– volume: 235
  start-page: 337
  year: 2016
  ident: ref76
  article-title: DLS and zeta potential - what they are and what they are not?
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2016.06.017
– volume: 11
  start-page: 3183
  year: 2021
  ident: ref106
  article-title: Engineering exosomes for targeted drug delivery
  publication-title: Theranostics
  doi: 10.7150/thno.52570
– volume: 23
  start-page: 1844
  year: 2018
  ident: ref35
  article-title: From plant compounds to botanicals and Back: a current snapshot
  publication-title: Molecules
  doi: 10.3390/molecules23081844
– volume: 54
  start-page: 524
  year: 2022
  ident: ref105
  article-title: Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines
  publication-title: Ann Med
  doi: 10.1080/07853890.2022.2031274
– volume: 24
  start-page: 96
  year: 2016
  ident: ref109
  article-title: Grapefruit-derived Nanovectors delivering therapeutic miR17 through an intranasal route inhibit brain tumor progression
  publication-title: Mol Ther J Am Soc Gene Ther
  doi: 10.1038/mt.2015.188
– volume: 15
  start-page: 505
  year: 2018
  ident: ref99
  article-title: Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
  publication-title: Nat Rev Cardiol
  doi: 10.1038/s41569-018-0064-2
– volume: 182
  start-page: 114108
  year: 2022
  ident: ref12
  article-title: Technology insight: plant-derived vesicles-how far from the clinical biotherapeutics and therapeutic drug carriers?
  publication-title: Adv Drug Deliv Rev
  doi: 10.1016/j.addr.2021.114108
– volume: 13
  start-page: 1026
  year: 2021
  ident: ref5
  article-title: Breast Milk: a source of functional compounds with potential application in nutrition and therapy
  publication-title: Nutrients
  doi: 10.3390/nu13031026
– volume: 4
  start-page: 28713
  year: 2015
  ident: ref48
  article-title: Ginger-derived nanoparticles protect against alcohol-induced liver damage
  publication-title: J Extracell Vesicles
  doi: 10.3402/jev.v4.28713
– volume: 86
  start-page: 108486
  year: 2020
  ident: ref52
  article-title: Nutritional implications of ginger: chemistry, biological activities and signaling pathways
  publication-title: J Nutr Biochem
  doi: 10.1016/j.jnutbio.2020.108486
– volume: 39
  start-page: 542
  year: 2018
  ident: ref83
  article-title: Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools
  publication-title: Acta Pharmacol Sin
  doi: 10.1038/aps.2017.178
– volume: 13
  start-page: 1686
  year: 2021
  ident: ref49
  article-title: Oral administration of ginger-derived lipid nanoparticles and Dmt1 siRNA potentiates the effect of dietary Iron restriction and mitigates pre-existing Iron overload in Hamp KO mice
  publication-title: Nutrients
  doi: 10.3390/nu13051686
– volume: 9
  start-page: 551
  year: 2019
  ident: ref34
  article-title: Antidiabetic potential of medicinal plants and their active components
  publication-title: Biomol Ther
  doi: 10.3390/biom9100551
– volume: 12
  start-page: 1927
  year: 2017
  ident: ref46
  article-title: Oral administration of ginger-derived nanolipids loaded with siRNA as a novel approach for efficient siRNA drug delivery to treat ulcerative colitis
  publication-title: Nanomedicine
  doi: 10.2217/nnm-2017-0196
– volume: 5
  start-page: 17319
  year: 2015
  ident: ref64
  article-title: Isolation of exosomes by differential centrifugation: theoretical analysis of a commonly used protocol
  publication-title: Sci Rep
  doi: 10.1038/srep17319
– volume: 8
  start-page: 2003505
  year: 2020
  ident: ref2
  article-title: Shedding light on extracellular vesicle biogenesis and bioengineering
  publication-title: Adv Sci
  doi: 10.1002/advs.202003505
– volume: 75
  start-page: 2520
  year: 2015
  ident: ref113
  article-title: Grapefruit-derived Nanovectors use an activated leukocyte trafficking pathway to deliver therapeutic agents to inflammatory tumor sites
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-14-3095
– volume: 11
  start-page: 87
  year: 2021
  ident: ref21
  article-title: Strawberry-derived exosome-like nanoparticles prevent oxidative stress in human mesenchymal stromal cells
  publication-title: Biomol Ther
  doi: 10.3390/biom11010087
– volume: 70
  start-page: 4725
  year: 2022
  ident: ref22
  article-title: Characterization of the MicroRNA profile of ginger exosome-like nanoparticles and their anti-inflammatory effects in intestinal Caco-2 cells
  publication-title: J Agric Food Chem
  doi: 10.1021/acs.jafc.1c07306
– volume: 214
  start-page: 113
  year: 2018
  ident: ref93
  article-title: The hidden mechanism beyond ginger (Zingiber officinale Rosc.) potent in vivo and in vitro anti-inflammatory activity
  publication-title: J Ethnopharmacol
  doi: 10.1016/j.jep.2017.12.019
– volume: 63
  start-page: 485
  year: 2020
  ident: ref112
  article-title: siRNA therapeutics: a clinical reality
  publication-title: Sci China Life Sci
  doi: 10.1007/s11427-018-9438-y
– volume: 20
  start-page: 206
  year: 2022
  ident: ref82
  article-title: Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis therapy
  publication-title: J Nanobiotechnol
  doi: 10.1186/s12951-022-01421-w
– volume: 48
  start-page: 7
  year: 2022
  ident: ref102
  article-title: Ginger and its constituents: role in treatment of inflammatory bowel disease
  publication-title: Biofactors
  doi: 10.1002/biof.1808
– volume: 15
  start-page: 5798
  year: 2023
  ident: ref36
  article-title: Ginseng-derived exosome-like nanovesicles extracted by sucrose gradient ultracentrifugation to inhibit osteoclast differentiation
  publication-title: Nanoscale
  doi: 10.1039/D2NR07018A
– volume: 10
  start-page: 1352
  year: 2022
  ident: ref26
  article-title: Citrus limonL.-derived Nanovesicles show an inhibitory effect on cell growth in p53-inactivated colorectal Cancer cells via the macropinocytosis pathway
  publication-title: Biomedicine
  doi: 10.3390/biomedicines10061352
– volume: 21
  start-page: 160
  year: 2023
  ident: ref40
  article-title: Novel plant-derived exosome-like nanovesicles from Catharanthus roseus: preparation, characterization, and immunostimulatory effect via TNF-alpha/NF-kappaB/PU.1 axis
  publication-title: J Nanobiotechnol
  doi: 10.1186/s12951-023-01919-x
– volume: 30
  start-page: 830
  year: 2009
  ident: ref90
  article-title: Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases
  publication-title: Endocr Rev
  doi: 10.1210/er.2009-0013
– volume: 66
  start-page: e2200142
  year: 2022
  ident: ref11
  article-title: Dietary exosome-like nanoparticles: an updated review on their pharmacological and drug delivery applications
  publication-title: Mol Nutr Food Res
  doi: 10.1002/mnfr.202200142
– volume: 101
  start-page: 321
  year: 2016
  ident: ref25
  article-title: Edible ginger-derived nanoparticles: a novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2016.06.018
– volume: 21
  start-page: 6
  year: 2023
  ident: ref27
  article-title: Tea leaf-derived exosome-like nanotherapeutics retard breast tumor growth by pro-apoptosis and microbiota modulation
  publication-title: J Nanobiotechnol
  doi: 10.1186/s12951-022-01755-5
– volume: 279
  start-page: 121178
  year: 2021
  ident: ref38
  article-title: ’Green’ nanotherapeutics from tea leaves for orally targeted prevention and alleviation of colon diseases
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2021.121178
– volume: 10
  start-page: 1023700
  year: 2022
  ident: ref8
  article-title: New frontiers of oral sciences: focus on the source and biomedical application of extracellular vesicles
  publication-title: Front Bioeng Biotechnol
  doi: 10.3389/fbioe.2022.1023700
– volume: 10
  start-page: e3685
  year: 2020
  ident: ref57
  article-title: Preparation and characterization of ginger lipid-derived nanoparticles for Colon-targeted siRNA delivery
  publication-title: Bio-protocol
  doi: 10.21769/BioProtoc.3685
– volume: 226
  start-page: 497
  year: 1957
  ident: ref84
  article-title: A simple method for the isolation and purification of total lipides from animal tissues
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)64849-5
– volume: 4
  start-page: 29509
  year: 2015
  ident: ref70
  article-title: High-speed centrifugation induces aggregation of extracellular vesicles
  publication-title: J Extracell Vesicles
  doi: 10.3402/jev.v4.29509
– volume: 11
  start-page: 4061
  year: 2021
  ident: ref44
  article-title: miR-375 prevents high-fat diet-induced insulin resistance and obesity by targeting the aryl hydrocarbon receptor and bacterial tryptophanase (tnaA) gene
  publication-title: Theranostics
  doi: 10.7150/thno.52558
– volume: 10
  start-page: e12182
  year: 2021
  ident: ref117
  article-title: Updating MISEV: evolving the minimal requirements for studies of extracellular vesicles
  publication-title: J extracell Vesicles
  doi: 10.1002/jev2.12182
– volume: 6
  start-page: 125
  year: 2014
  ident: ref88
  article-title: Active ingredients of ginger as potential candidates in the prevention and treatment of diseases via modulation of biological activities
  publication-title: Int J Physiol Pathophysiol Pharmacol
– volume: 86
  start-page: 2838
  year: 2021
  ident: ref32
  article-title: Plant-derived exosome-like nanoparticles: a concise review on its extraction methods, content, bioactivities, and potential as functional food ingredient
  publication-title: J Food Sci
  doi: 10.1111/1750-3841.15787
– volume: 50
  start-page: 1007
  year: 2022
  ident: ref104
  article-title: Zingiber officinale: a systematic review of botany, Phytochemistry and pharmacology of gut microbiota-related gastrointestinal benefits
  publication-title: Am J Chin Med
  doi: 10.1142/S0192415X22500410
– volume: 367
  start-page: eaau6977
  year: 2020
  ident: ref9
  article-title: The biology, function, and biomedical applications of exosomes
  publication-title: Science
  doi: 10.1126/science.aau6977
– volume: 414
  start-page: 115425
  year: 2021
  ident: ref15
  article-title: Edible plant-derived exosomal microRNAs: exploiting a cross-kingdom regulatory mechanism for targeting SARS-CoV-2
  publication-title: Toxicol Appl Pharmacol
  doi: 10.1016/j.taap.2021.115425
– volume: 10
  start-page: 4456
  year: 2020
  ident: ref45
  article-title: A cost-effective polyethylene glycol-based method for the isolation of functional edible nanoparticles from ginger rhizomes
  publication-title: Sci Rep
  doi: 10.1038/s41598-020-61358-8
– volume: 7
  start-page: 789
  year: 2017
  ident: ref68
  article-title: Progress in exosome isolation techniques
  publication-title: Theranostics
  doi: 10.7150/thno.18133
– volume: 127
  start-page: 645
  year: 2019
  ident: ref1
  article-title: Emerging role of extracellular vesicles in the regulation of skeletal muscle adaptation
  publication-title: J Appl Physiol
  doi: 10.1152/japplphysiol.00914.2018
– volume: 141
  start-page: 4640
  year: 2016
  ident: ref72
  article-title: Effective isolation of exosomes with polyethylene glycol from cell culture supernatant for in-depth proteome profiling
  publication-title: Analyst
  doi: 10.1039/C6AN00892E
– volume: 38
  start-page: 754
  year: 2017
  ident: ref6
  article-title: Engineering exosomes as refined biological nanoplatforms for drug delivery
  publication-title: Acta Pharmacol Sin
  doi: 10.1038/aps.2017.12
– volume: 27
  start-page: 8184
  year: 2022
  ident: ref24
  article-title: Edible Pueraria lobata-derived exosomes promote M2 macrophage polarization
  publication-title: Molecules
  doi: 10.3390/molecules27238184
– volume: 17
  start-page: 53
  year: 2022
  ident: ref115
  article-title: Plant-derived exosome-like nanoparticles and their therapeutic activities
  publication-title: Asian J Pharm Sci
  doi: 10.1016/j.ajps.2021.05.006
– volume: 8
  start-page: 4912
  year: 2018
  ident: ref13
  article-title: Blood exosomes regulate the tissue distribution of grapefruit-derived nanovector via CD36 and IGFR1 pathways
  publication-title: Theranostics
  doi: 10.7150/thno.27608
– volume: 18
  start-page: 2114
  year: 2021
  ident: ref97
  article-title: NLRP3 inflammasome activation and cell death
  publication-title: Cell Mol Immunol
  doi: 10.1038/s41423-021-00740-6
– volume: 33
  start-page: 1639
  year: 2019
  ident: ref89
  article-title: Does ginger supplementation lower blood pressure? A systematic review and meta-analysis of clinical trials
  publication-title: Phytother Res PTR
  doi: 10.1002/ptr.6362
– volume: 73
  start-page: 1907
  year: 2010
  ident: ref81
  article-title: Exosomes: extracellular organelles important in intercellular communication
  publication-title: J Proteome
  doi: 10.1016/j.jprot.2010.06.006
– volume: 7
  start-page: 1535750
  year: 2018
  ident: ref118
  article-title: Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
  publication-title: J Extracell Vesicles
  doi: 10.1080/20013078.2018.1535750
– volume: 7
  start-page: 125
  year: 2018
  ident: ref17
  article-title: Leucine-rich repeat-containing G-protein coupled receptor 5 gene overexpression of the rat small intestinal progenitor cells in response to orally administered grape exosome-like Nanovesicles
  publication-title: Adv Biomed Res
  doi: 10.4103/abr.abr_114_18
– volume: 9
  start-page: e3390
  year: 2019
  ident: ref58
  article-title: Isolation, purification, and characterization of ginger-derived nanoparticles (GDNPs) from ginger, rhizome of Zingiber officinale
  publication-title: Bio-protocol
  doi: 10.21769/BioProtoc.3390
– volume: 10
  start-page: 1881
  year: 2021
  ident: ref60
  article-title: The herbal formula JI017 induces ER stress via Nox4 in breast Cancer cells
  publication-title: Antioxidants
  doi: 10.3390/antiox10121881
– volume: 11
  start-page: 267
  year: 2020
  ident: ref100
  article-title: The immune landscape of visceral adipose tissue during obesity and aging
  publication-title: Front Endocrinol
  doi: 10.3389/fendo.2020.00267
– volume: 11
  start-page: 10
  year: 2018
  ident: ref103
  article-title: Interactions between bacteriophage, Bacteria, and the mammalian immune system
  publication-title: Viruses
  doi: 10.3390/v11010010
– volume: 12
  start-page: 1388
  year: 2022
  ident: ref20
  article-title: Ginger nanoparticles mediated induction of Foxa2 prevents high-fat diet-induced insulin resistance
  publication-title: Theranostics
  doi: 10.7150/thno.62514
– volume: 16
  start-page: 2690
  year: 2019
  ident: ref23
  article-title: Exosome-like nanoparticles from ginger rhizomes inhibited NLRP3 Inflammasome activation
  publication-title: Mol Pharm
  doi: 10.1021/acs.molpharmaceut.9b00246
– volume: 27
  start-page: 112
  year: 2016
  ident: ref95
  article-title: Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation
  publication-title: J Nutr Biochem
  doi: 10.1016/j.jnutbio.2015.08.025
– volume: 269
  start-page: 120467
  year: 2021
  ident: ref108
  article-title: Extracellular vesicles: a bright star of nanomedicine
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2020.120467
– volume: 13
  start-page: 3066
  year: 2020
  ident: ref79
  article-title: Formulation of Bicelles based on lecithin-nonionic surfactant mixtures
  publication-title: Materials
  doi: 10.3390/ma13143066
– volume: 117
  start-page: 554
  year: 2015
  ident: ref54
  article-title: Gingerols and shogaols: important nutraceutical principles from ginger
  publication-title: Phytochemistry
  doi: 10.1016/j.phytochem.2015.07.012
– volume: 174
  start-page: 63
  year: 2017
  ident: ref7
  article-title: Exosomes: therapy delivery tools and biomarkers of diseases
  publication-title: Pharmacol Ther
  doi: 10.1016/j.pharmthera.2017.02.020
– volume: 23
  start-page: 100869
  year: 2020
  ident: ref28
  article-title: Plant-derived Exosomal nanoparticles inhibit pathogenicity of Porphyromonas gingivalis
  publication-title: iScience
  doi: 10.1016/j.isci.2020.100869
– volume: 66
  start-page: 153
  year: 2019
  ident: ref92
  article-title: Does diet play a role in reducing nociception related to inflammation and chronic pain?
  publication-title: Nutrition
  doi: 10.1016/j.nut.2019.04.007
– volume: 29
  start-page: 2424
  year: 2021
  ident: ref42
  article-title: Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12
  publication-title: Mol Ther J Am Soc Gene Ther
  doi: 10.1016/j.ymthe.2021.05.005
– volume: 1295
  start-page: 179
  year: 2015
  ident: ref66
  article-title: A protocol for exosome isolation and characterization: evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-4939-2550-6_15
– volume: 14
  start-page: 571
  year: 2021
  ident: ref91
  article-title: Benefits of ginger and its constituent 6-Shogaol in inhibiting inflammatory processes
  publication-title: Pharmaceuticals
  doi: 10.3390/ph14060571
– volume: 29
  start-page: 13
  year: 2021
  ident: ref110
  article-title: Plant exosome-like Nanovesicles: emerging therapeutics and drug delivery Nanoplatforms
  publication-title: Mol Ther J Am Soc Gene Ther
  doi: 10.1016/j.ymthe.2020.11.030
– volume: 116
  start-page: 281
  year: 2004
  ident: ref85
  article-title: MicroRNAs: genomics, biogenesis, mechanism, and function
  publication-title: Cells
  doi: 10.1016/S0092-8674(04)00045-5
– volume: 21
  start-page: 308
  year: 2019
  ident: ref61
  article-title: Plant-derived Exosomal nanoparticles inhibit pathogenicity of Porphyromonas gingivalis
  publication-title: iScience
  doi: 10.1016/j.isci.2019.10.032
– volume: 13
  start-page: 20157
  year: 2021
  ident: ref43
  article-title: A biomimetic nanocomposite made of a ginger-derived exosome and an inorganic framework for high-performance delivery of oral antibodies
  publication-title: Nanoscale
  doi: 10.1039/D1NR06015E
– volume: 44
  start-page: 450
  year: 2016
  ident: ref96
  article-title: Macrophages in tissue repair, regeneration, and fibrosis
  publication-title: Immunity
  doi: 10.1016/j.immuni.2016.02.015
– volume: 51
  start-page: 1039
  year: 2022
  ident: ref78
  article-title: Application of emerging plant-derived nanoparticles as a novel approach for Nano-drug delivery systems
  publication-title: Immunol Investig
  doi: 10.1080/08820139.2021.1891094
– volume: 10
  start-page: 291
  year: 2020
  ident: ref98
  article-title: Endothelial dysfunction in obesity-induced inflammation: molecular mechanisms and clinical implications
  publication-title: Biomol Ther
  doi: 10.3390/biom10020291
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Snippet Edible plant-derived exosome-like nanoparticles (PELNs) provide numerous benefits, including high yield, low cost, ethical compatibility, and multiple health...
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SubjectTerms exosome
ginger
herb
nanoparticle
Nutrition
traditional Chinese medicine
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Title Ginger: a representative material of herb-derived exosome-like nanoparticles
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