Deciphering azole resistance mechanisms with a focus on transcription factor-encoding genes TAC1 , MRR1 and UPC2 in a set of fluconazole-resistant clinical isolates of Candida albicans

• Published in: International journal of antimicrobial agents Vol. 42; no. 5; pp. 410 - 415
• Main Authors: Morio, Florent, Pagniez, Fabrice, Besse, Myriam, Gay-andrieu, Françoise, Miegeville, Michel, Le Pape, Patrice
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2013
• Subjects: Adult; Animals; Antifungal Agents - pharmacology; Azole antifungals; Candida albicans; Candida albicans - drug effects; Candida albicans - genetics; Candida albicans - isolation & purification; Candidiasis - microbiology; Drug Resistance, Fungal; Efflux pumps; Female; Fluconazole - pharmacology; Gene Expression Profiling; Humans; Infectious Disease; Life Sciences; Male; Mice; Microbiology and Parasitology; Middle Aged; Molecular mechanisms; Mutation, Missense; Resistance; Reverse Transcriptase Polymerase Chain Reaction; Santé publique et épidémiologie; Sequence Analysis, DNA; Transcription factors; Transcription Factors - biosynthesis; Transcription Factors - genetics; Candida albicans; Resistance; Efflux pumps; Azole antifungals; Transcription factors; Molecular mechanisms

Abstract Several and often combined mechanisms can lead to acquired azole resistance in Candida albicans and subsequent therapeutic failure. The aim of this study was to provide a complete overview of the molecular basis of azole resistance in a set of six C. albicans clinical isolates recovered fro...