Ascorbic acid may protect against human gastric cancer by scavenging mucosal oxygen radicals

• Published in: Carcinogenesis (New York) Vol. 17; no. 3; pp. 559 - 562
• Main Authors: Drake, Ian M., Davies, Michael J., Mapstone, Nic P., Dixon, Michael F., Schorah, Chris J., White, Kay L.M., Chalmers, Douglas M., Axon, Anthony T.R.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.03.1996
• Subjects: Adult; Ascorbic Acid - analysis; Ascorbic Acid - metabolism; Biological and medical sciences; Free Radical Scavengers - metabolism; Gastric Mucosa - chemistry; Gastric Mucosa - metabolism; Gastritis - microbiology; Gastroenterology. Liver. Pancreas. Abdomen; Helicobacter Infections - metabolism; Helicobacter pylori; Humans; Luminescent Measurements; Malondialdehyde - analysis; Medical sciences; Middle Aged; Reactive Oxygen Species - metabolism; Stomach Neoplasms - prevention & control; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; Human; Stomach; Oxygen; Ascorbic acid; Spirillales; Mucosa; Vitamin; Spirillaceae; Malignant tumor; Anticarcinogen; Antioxidant; Carcinogenesis; Radical scavenger; Gastritis; Prevention; Helicobacter pylori; Digestive diseases; Bacteria; Gastric disease

High dietary ascorbic acid intake appears to protect against gastric cancer. This may be due to its action as a scavenger of reactive radical species formed in the gastric mucosa, resulting in a reduced level of radical-mediated DNA damage. We have studied 82 patients, of whom 37 had Helicobacter py...