HMGA2 regulation by miRNAs in cancer: Affecting cancer hallmarks and therapy response

• Published in: Pharmacological research Vol. 190; p. 106732
• Main Authors: Hashemi, Mehrdad, Rashidi, Mohsen, Hushmandi, Kiavash, ten Hagen, Timo L.M., Salimimoghadam, Shokooh, Taheriazam, Afshin, Entezari, Maliheh, Falahati, Mojtaba
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.04.2023; Elsevier
• Subjects: Cancer; Cell Line, Tumor; CircRNAs; HMGA2; HMGA2 Protein - metabolism; Humans; LncRNA; MicroRNAs - genetics; MicroRNAs - metabolism; MiRNA; Neoplasms - drug therapy; Neoplasms - genetics; RNA, Circular - genetics; RNA, Long Noncoding - metabolism; RNA, Untranslated - genetics; EIF4A2; LSCC; RKIP; SERPINE1; TGF-βR1; LncRNA; NR3C1; BZW1; CircRNA; SOX2; HOXA9; PI3K; SOX4; PDGFRA; CPT1A; MDR-1; POSTN; MiRNA; AI; MITF; Snail; DCTD; EGF-L7; PDAC; HNSCC; RBP1; TXNIP; CircRNAs; ERK; ceRNA; ABCB1; YAP; Chk1; HIF1A; IKKε; HBXIP; GSK-3β; PD-L1; ATG5; SMAD2; OSCC; KLHL21; HMGA2; NETO2; PAICS; HNRNPK; SP1; ZEB; MDM2; NF1; TCF3; ATR; Cancer; TAM; FEN1; HNF4G; PTEN; LAMC2; BRCA1; ALDH1; LTBP-1; DNMT3B; mTOR; OLR1; P-gp; MMP2; HCC; TET1; FOXL2; MAPK; ESCC; LATS1; PCL; MET; PTC; Bcl-2; VEGFR2; NF-κB1; ROCK1; THBS2; CBP; ER-α36; BCLAF1; GBM; MTA1; U2AF2; TP53INP1; E2F1; Foxi1; PP4R1; AP1; Tgfbr3; STAT3; NcRNA; HN1; TME; FAK; PEG; PLGA; APC; KRT17; PEI; eIF5A2

High mobility group A 2 (HMGA2) is a protein that modulates the structure of chromatin in the nucleus. Importantly, aberrant expression of HMGA2 occurs during carcinogenesis, and this protein is an upstream mediator of cancer hallmarks including evasion of apoptosis, proliferation, invasion, metasta...