The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease

• Published in: Cell metabolism Vol. 33; no. 10; pp. 1926 - 1942.e8
• Main Authors: Zhu, Han, Cao, Chujin, Wu, Zhongcai, Zhang, Heping, Sun, Zhihong, Wang, Meng, Xu, Huzi, Zhao, Zhi, Wang, Yuxi, Pei, Guangchang, Yang, Qian, Zhu, Fengming, Yang, Juan, Deng, Xuan, Hong, Yu, Li, Yinzheng, Sun, Jie, Zhu, Fan, Shi, Mengxia, Qian, Kun, Ye, Ting, Zuo, Xuezhi, Zhao, Fenfei, Guo, Jing, Xu, Gang, Yao, Ying, Zeng, Rui
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.10.2021
• Subjects: acute kidney injury; Animals; chronic kidney disease; Dysbiosis; Fatty Acids, Volatile - metabolism; gut microbiota; Lactobacillus casei - metabolism; Lactobacillus casei Zhang; Mice; nicotinamide; Probiotics - therapeutic use; Renal Insufficiency, Chronic; short-chain fatty acids; Lactobacillus casei Zhang; chronic kidney disease; acute kidney injury; short-chain fatty acids; gut microbiota; nicotinamide

The relationship between gut microbial dysbiosis and acute or chronic kidney disease (CKD) is still unclear. Here, we show that oral administration of the probiotic Lactobacillus casei Zhang (L. casei Zhang) corrected bilateral renal ischemia-reperfusion (I/R)-induced gut microbial dysbiosis, allevi...