Integrated bioinformatic analysis and cell line experiments reveal the significant role of the novel immune checkpoint TIGIT in kidney renal clear cell carcinoma

• Published in: Frontiers in oncology Vol. 13; p. 1096341
• Main Authors: Xia, Qi-Dong, Li, Bo, Sun, Jian-Xuan, Liu, Chen-Qian, Xu, Jin-Zhou, An, Ye, Xu, Meng-Yao, Zhang, Si-Han, Zhong, Xing-Yu, Zeng, Na, Ma, Si-Yang, He, Hao-Dong, Zhang, Yu-Cong, Guan, Wei, Li, Heng, Wang, Shao-Gang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 24.03.2023
• Subjects: immunotherapy; KIRC; molecular docking; Oncology; targeted therapy; TIGIT; targeted therapy; molecular docking; KIRC; TIGIT; immunotherapy

T cell immunoglobulin and ITIM domain (TIGIT) is a widely concerned immune checkpoint, which plays an essential role in immunosuppression and immune evasion. However, the role of TIGIT in normal organ tissues and renal clear cell carcinoma is unclear. We aim to identify the critical role of TIGIT in...