Distinct Phosphatases Mediate the Deactivation of the DNA Damage Checkpoint Kinase Rad53

• Published in: The Journal of biological chemistry Vol. 283; no. 25; pp. 17123 - 17130
• Main Authors: Travesa, Anna, Duch, Alba, Quintana, David G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.06.2008; American Society for Biochemistry and Molecular Biology
• Subjects: Cell Cycle; Cell Cycle Proteins - metabolism; Checkpoint Kinase 2; DNA Damage; DNA Methylation; DNA Replication; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Mutation; Phosphoprotein Phosphatases - metabolism; Phosphoric Monoester Hydrolases - metabolism; Phosphorylation; Protein Phosphatase 2; Protein Phosphatase 2C; Protein-Serine-Threonine Kinases - metabolism; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - metabolism

The DNA damage checkpoint regulates DNA replication and arrests cell cycle progression in response to genotoxic stress. In Saccharomyces cerevisiae, the protein kinase Rad53 plays a central role in preventing genomic instability and maintaining viability in the presence of replication stress and DNA...