Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects

• Published in: Cell metabolism Vol. 33; no. 8; pp. 1701 - 1715.e5
• Main Authors: Dierge, Emeline, Debock, Elena, Guilbaud, Céline, Corbet, Cyril, Mignolet, Eric, Mignard, Louise, Bastien, Estelle, Dessy, Chantal, Larondelle, Yvan, Feron, Olivier
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.08.2021
• Subjects: acidosis; Animals; cancer; diacylglycerol acyltransferase; docosahexaenoic acid; Fatty Acids; Fatty Acids, Omega-3 - pharmacology; Fatty Acids, Omega-6 - pharmacology; Fatty Acids, Unsaturated - metabolism; Ferroptosis; lipid droplets; Mice; Neoplasms - drug therapy; peroxidation; polyunsaturated fatty acids; spheroids; ferroptosis; fatty acids; peroxidation; diacylglycerol acyltransferase; acidosis; docosahexaenoic acid; polyunsaturated fatty acids; cancer; lipid droplets; spheroids

Tumor acidosis promotes disease progression through a stimulation of fatty acid (FA) metabolism in cancer cells. Instead of blocking the use of FAs by acidic cancer cells, we examined whether excess uptake of specific FAs could lead to antitumor effects. We found that n-3 but also remarkably n-6 pol...