Optimizing sedation in patients with acute brain injury

• Published in: Critical care (London, England) Vol. 20; no. 1; p. 128
• Main Authors: Oddo, Mauro, Crippa, Ilaria Alice, Mehta, Sangeeta, Menon, David, Payen, Jean-Francois, Taccone, Fabio Silvio, Citerio, Giuseppe
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.05.2016; BioMed Central
• Subjects: Analgesia - adverse effects; Analgesia - methods; Brain; Brain Injuries - complications; Brain Injuries - drug therapy; Clinical trials; Critical Care - methods; Critical Illness - nursing; Deep Sedation - adverse effects; Deep Sedation - methods; Deep Sedation - standards; Electroencephalography; Humans; Hypnotics and Sedatives - adverse effects; Hypnotics and Sedatives - pharmacology; Hypnotics and Sedatives - therapeutic use; Injuries; Intensive Care Units; Ketamine - adverse effects; Ketamine - pharmacology; Ketamine - therapeutic use; Midazolam - adverse effects; Midazolam - pharmacology; Midazolam - therapeutic use; Propofol - adverse effects; Propofol - pharmacology; Propofol - therapeutic use; Respiration, Artificial - adverse effects; Respiration, Artificial - nursing; Review

Daily interruption of sedative therapy and limitation of deep sedation have been shown in several randomized trials to reduce the duration of mechanical ventilation and hospital length of stay, and to improve the outcome of critically ill patients. However, patients with severe acute brain injury (A...