Viral Ubiquitin Ligase Stimulates Selective Host MicroRNA Expression by Targeting ZEB Transcriptional Repressors

• Published in: Viruses Vol. 9; no. 8; p. 210
• Main Authors: Lutz, Gabriel, Jurak, Igor, Kim, Eui Tae, Kim, Ju Youn, Hackenberg, Michael, Leader, Andrew, Stoller, Michelle L., Fekete, Donna M., Weitzman, Matthew D., Coen, Donald M., Wilson, Angus C.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.08.2017; MDPI
• Subjects: Cell Nucleus; Cells, Cultured; Crystallin; E3 ubiquitin ligase; Fibroblasts; Fibroblasts - virology; Gene expression; Gene Expression Regulation; Herpes simplex; herpes simplex virus; Herpesvirus 1, Human - enzymology; Herpesvirus 1, Human - genetics; Homeobox; host shutoff; Host-Pathogen Interactions; HSV-1; Humans; ICP0; Immediate-Early Proteins - deficiency; Immediate-Early Proteins - genetics; Kinases; microRNA; MicroRNAs - genetics; miR-182; miR-183; miR-96; miRNA; mRNA stability; Nerve Tissue Proteins - genetics; Neurons - virology; Non-coding RNA; Protein Binding; Proteolysis; Repressors; RNA-Binding Proteins - genetics; Smad protein; Transcription factors; Ubiquitin; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - deficiency; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Virus Replication; ZEB; Zinc Finger E-box-Binding Homeobox 1 - genetics; Zinc Finger E-box-Binding Homeobox 1 - metabolism; Zinc finger proteins; herpes simplex virus; HSV-1; host shutoff; ZEB; ICP0; miR-182; miR-183; miR-96; microRNA; E3 ubiquitin ligase

Infection with herpes simplex virus-1 (HSV-1) brings numerous changes in cellular gene expression. Levels of most host mRNAs are reduced, limiting synthesis of host proteins, especially those involved in antiviral defenses. The impact of HSV-1 on host microRNAs (miRNAs), an extensive network of shor...