High Molecular Weight Hyaluronan Suppresses Macrophage M1 Polarization and Enhances IL-10 Production in PM2.5-Induced Lung Inflammation

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 9; p. 1766
• Main Authors: Shi, Qiwen, Zhao, Lan, Xu, Chenming, Zhang, Leifang, Zhao, Hang
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 07.05.2019; MDPI
• Subjects: Air pollution; Apoptosis; Asthma; Biomarkers; Cancer; Chemokines; Chronic obstructive pulmonary disease; Coal-fired power plants; Cytokines; Genotype & phenotype; hyalruonan; Hyaluronic acid; IL-10; Inflammation; macrophage polarization; Molecular weight; Neutrophils; Oxidative stress; Phosphorylation; PM2.5; Tumor necrosis factor-TNF

PM2.5 is particulate matter with a diameter of 2.5 μm or less. Airway macrophages are the key players regulating PM2.5-induced inflammation. High molecular weight hyaluronan (HMW-HA) has previously been shown to exert protective effects on PM2.5-induced acute lung injury and inflammation. However, l...