Surgical angiogenesis modifies the cellular environment of nerve allografts in a rat sciatic nerve defect model

•The microenvironment of nerve allograft may be altered to diminish nerve rejection.•Flowcytometry may be used to evaluate T cell population over time.•Vascularity in nerve may be evaluated using biomarkers and immunohistochemistry.•Surgical angiogenesis to nerve graft results in enhanced angiogenic...

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Published inGene Vol. 751; p. 144711
Main Authors Saffari, Tiam M., Badreldin, Amr, Mathot, Femke, Bagheri, Leila, Bishop, Allen T., van Wijnen, Andre J., Shin, Alexander Y.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.08.2020
Subjects
Allografts
Animals
Cellular Microenvironment
Disease Models, Animal
Male
Neovascularization, Physiologic
Nerve Regeneration
Peripheral Nerve Injuries - pathology
Peripheral Nerve Injuries - therapy
Rats
Rats, Inbred Lew
Sciatic Nerve - injuries
Sciatic Nerve - physiology
Sciatic Nerve - surgery
Sciatic Nerve - transplantation
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Summary:•The microenvironment of nerve allograft may be altered to diminish nerve rejection.•Flowcytometry may be used to evaluate T cell population over time.•Vascularity in nerve may be evaluated using biomarkers and immunohistochemistry.•Surgical angiogenesis to nerve graft results in enhanced angiogenic gene expression.•Increased vascularity in nerve graft was confirmed using staining against CD34.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2020.144711