Exploring Pharmacokinetic interactions between SHR8554, a µ-opioid receptor biased agonist, and Itraconazole in healthy Chinese subjects - Huang, Lei; Jiang, Hao; Huang, Yuanyuan; Li, Juan (Scientific reports, 2025)
Keywords: 631/154/1438; 631/154/436/1729; Adult; Biased agonist; CYP3A4 inhibitors; Cytochrome P-450 CYP3A - metabolism; Cytochrome P-450 CYP3A Inhibitors - administration & dosage; Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics; Drug Interactions; Drug-drug interaction; East Asian People; Female; Healthy Volunteers; Humanities and Social Sciences; Humans; Itraconazole - administration & dosage; Itraconazole - pharmacokinetics; Male; multidisciplinary; Receptors, Opioid, mu - agonists; Science; Science (multidisciplinary); SHR8554; Young Adult; Μ- opioid receptors; CYP3A4 inhibitors; Μ- opioid receptors; Biased agonist; Drug-drug interaction; SHR8554