Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer

Altered lipid metabolism is among the most prominent metabolic alterations in cancer. Enhanced synthesis or uptake of lipids contributes to rapid cancer cell growth and tumor formation. Lipids are a highly complex group of biomolecules that not only constitute the structural basis of biological memb...

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Published in	Cell metabolism Vol. 31; no. 1; pp. 62 - 76
Main Authors	Snaebjornsson, Marteinn Thor, Janaki-Raman, Sudha, Schulze, Almut
Format	Journal Article
Language	English
Published	United States Elsevier Inc 07.01.2020
Subjects	cancer Cholesterol - biosynthesis Cholesterol - genetics Cholesterol - metabolism Energy Metabolism - genetics fatty acid desaturation fatty acids Fatty Acids - biosynthesis Fatty Acids - genetics Fatty Acids - metabolism Ferroptosis - genetics Humans lipid metabolism Lipid Metabolism - genetics lipid remodeling mevalonate Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Signal Transduction - drug effects Signal Transduction - genetics Signal Transduction - physiology Stress, Physiological - drug effects Stress, Physiological - genetics Stress, Physiological - physiology Tumor Microenvironment - genetics lipid remodeling cancer fatty acids fatty acid desaturation mevalonate lipid metabolism
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Abstract	Altered lipid metabolism is among the most prominent metabolic alterations in cancer. Enhanced synthesis or uptake of lipids contributes to rapid cancer cell growth and tumor formation. Lipids are a highly complex group of biomolecules that not only constitute the structural basis of biological membranes but also function as signaling molecules and an energy source. Here, we summarize recent evidence implicating altered lipid metabolism in different aspects of the cancer phenotype and discuss potential strategies by which targeting lipid metabolism could provide a therapeutic window for cancer treatment. Altered lipid metabolism is a prominent feature of metabolic reprogramming in cancer. Here, Snaebjornsson et al. discuss how lipid metabolism impacts tumor growth, energy metabolism, and stress response. Furthermore, the authors emphasize recent evidence demonstrating the non-cell-autonomous roles of lipids in the tumor microenvironment and their importance in tumor progression.
AbstractList	Altered lipid metabolism is among the most prominent metabolic alterations in cancer. Enhanced synthesis or uptake of lipids contributes to rapid cancer cell growth and tumor formation. Lipids are a highly complex group of biomolecules that not only constitute the structural basis of biological membranes but also function as signaling molecules and an energy source. Here, we summarize recent evidence implicating altered lipid metabolism in different aspects of the cancer phenotype and discuss potential strategies by which targeting lipid metabolism could provide a therapeutic window for cancer treatment. Altered lipid metabolism is a prominent feature of metabolic reprogramming in cancer. Here, Snaebjornsson et al. discuss how lipid metabolism impacts tumor growth, energy metabolism, and stress response. Furthermore, the authors emphasize recent evidence demonstrating the non-cell-autonomous roles of lipids in the tumor microenvironment and their importance in tumor progression. Altered lipid metabolism is among the most prominent metabolic alterations in cancer. Enhanced synthesis or uptake of lipids contributes to rapid cancer cell growth and tumor formation. Lipids are a highly complex group of biomolecules that not only constitute the structural basis of biological membranes but also function as signaling molecules and an energy source. Here, we summarize recent evidence implicating altered lipid metabolism in different aspects of the cancer phenotype and discuss potential strategies by which targeting lipid metabolism could provide a therapeutic window for cancer treatment.
Author	Janaki-Raman, Sudha Snaebjornsson, Marteinn Thor Schulze, Almut
Author_xml	– sequence: 1 givenname: Marteinn Thor surname: Snaebjornsson fullname: Snaebjornsson, Marteinn Thor email: m.snaebjoernsson@dkfz-heidelberg.de organization: Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Am Hubland, 97074 Würzburg, Germany – sequence: 2 givenname: Sudha surname: Janaki-Raman fullname: Janaki-Raman, Sudha email: sudha.janaki_raman@uni-wuerzburg.de organization: Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Am Hubland, 97074 Würzburg, Germany – sequence: 3 givenname: Almut surname: Schulze fullname: Schulze, Almut email: almut.schulze@dkfz-heidelberg.de organization: Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Am Hubland, 97074 Würzburg, Germany
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31813823$$D View this record in MEDLINE/PubMed
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Snippet	Altered lipid metabolism is among the most prominent metabolic alterations in cancer. Enhanced synthesis or uptake of lipids contributes to rapid cancer cell...
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SubjectTerms	cancer Cholesterol - biosynthesis Cholesterol - genetics Cholesterol - metabolism Energy Metabolism - genetics fatty acid desaturation fatty acids Fatty Acids - biosynthesis Fatty Acids - genetics Fatty Acids - metabolism Ferroptosis - genetics Humans lipid metabolism Lipid Metabolism - genetics lipid remodeling mevalonate Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Signal Transduction - drug effects Signal Transduction - genetics Signal Transduction - physiology Stress, Physiological - drug effects Stress, Physiological - genetics Stress, Physiological - physiology Tumor Microenvironment - genetics
Title	Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer
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