Associations in asthma between quantitative computed tomography and bronchial biopsy-derived airway remodelling

• Published in: The European respiratory journal Vol. 49; no. 5; p. 1601507
• Main Authors: Berair, Rachid, Hartley, Ruth, Mistry, Vijay, Sheshadri, Ajay, Gupta, Sumit, Singapuri, Amisha, Gonem, Sherif, Marshall, Richard P., Sousa, Ana R., Shikotra, Aarti, Kay, Richard, Wardlaw, Andrew, Bradding, Peter, Siddiqui, Salman, Castro, Mario, Brightling, Christopher E.
• Format: Journal Article
• Language: English
• Published: England European Respiratory Society Journals Ltd 01.05.2017
• Subjects: Adult; Airway Remodeling; Asthma; Asthma - diagnostic imaging; Asthma - pathology; Biopsy; Bronchi - pathology; Bronchodilators; Computed tomography; Densitometry; Female; Forced Expiratory Volume; Humans; Linear Models; Lung - physiopathology; Male; Middle Aged; Morphometry; Multivariate Analysis; Replication; Respiratory function; Respiratory tract; Smooth muscle; Thorax; Tomography, X-Ray Computed; United Kingdom; United States; Vital Capacity

Airway remodelling in asthma remains poorly understood. This study aimed to determine the association of airway remodelling measured on bronchial biopsies with 1) lung function impairment and 2) thoracic quantitative computed tomography (QCT)-derived morphometry and densitometry measures of proximal...