Modified Labeling Technique for in vivo Visualization of Platelets in the Cerebral Microcirculation of Mongolian Gerbils

• Published in: Journal of cerebral blood flow and metabolism Vol. 27; no. 2; pp. 327 - 333
• Main Authors: Waldner, Maximilian, Hutter, Joerg, Uhl, Eberhard, Baethmann, Alexander, Lehmberg, Jens
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.02.2007; Lippincott Williams & Wilkins; Sage Publications Ltd
• Subjects: Adenosine Diphosphate - pharmacology; Animals; Biological and medical sciences; Blood Platelets - physiology; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges; Cerebrovascular Circulation - physiology; Flow Cytometry; Fundamental and applied biological sciences. Psychology; Gerbillinae; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Male; Medical sciences; Meriones unguiculatus; Microcirculation - physiology; Microscopy, Fluorescence; Microscopy, Video; Nervous system (semeiology, syndromes); Neurology; Platelet Aggregation - drug effects; Stereotaxic Techniques; Vascular diseases and vascular malformations of the nervous system; Vertebrates: nervous system and sense organs; pial vasculature; thrombosis; animal model; fluorescence microscopy; Gerbil; microcirculation; Animal model; Visualization; Nervous system diseases; Rodentia; Cardiovascular disease; Thrombosis; Cerebral disorder; Vascular disease; Microcirculation; Vertebrata; Platelet; Mammalia; Central nervous system disease; Cerebrovascular disease; Fluorescence microscopy

Activation of platelets induces interactions with platelets, endothelial cells, and leukocytes. In vivo observation of these interactions in the cerebral microcirculation is rare. The purpose of the present study was to develop a model enabling the in vivo observation of platelet kinetics in the cer...