Host Cell Restriction Factors that Limit Influenza A Infection

• Published in: Viruses Vol. 9; no. 12; p. 376
• Main Authors: Villalón-Letelier, Fernando, Brooks, Andrew G, Saunders, Philippa M, Londrigan, Sarah L, Reading, Patrick C
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.12.2017; MDPI
• Subjects: Animals; Antiviral activity; Gene silencing; Genomes; Host-Pathogen Interactions; Humans; Immunologic Factors - metabolism; Infections; Influenza; Influenza A; Influenza A virus - immunology; innate; Interferon; interferon-stimulated gene; replication; restriction factor; Review; Viral infections; Viruses; influenza; replication; restriction factor; interferon-stimulated gene; innate

Viral infection of different cell types induces a unique spectrum of host defence genes, including interferon-stimulated genes (ISGs) and genes encoding other proteins with antiviral potential. Although hundreds of ISGs have been described, the vast majority have not been functionally characterised....