Single-cell atlas of domestic pig cerebral cortex and hypothalamus

[Display omitted] The brain of the domestic pig (Sus scrofa domesticus) has drawn considerable attention due to its high similarities to that of humans. However, the cellular compositions of the pig brain (PB) remain elusive. Here we investigated the single-nucleus transcriptomic profiles of five re...

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Published inScience bulletin Vol. 66; no. 14; pp. 1448 - 1461
Main Authors Zhu, Jiacheng, Chen, Fang, Luo, Lihua, Wu, Weiying, Dai, Jinxia, Zhong, Jixing, Lin, Xiumei, Chai, Chaochao, Ding, Peiwen, Liang, Langchao, Wang, Shiyou, Ding, Xiangning, Chen, Yin, Wang, Haoyu, Qiu, Jiaying, Wang, Feiyue, Sun, Chengcheng, Zeng, Yuying, Fang, Jian, Jiang, Xiaosen, Liu, Ping, Tang, Gen, Qiu, Xin, Zhang, Xingliang, Ruan, Yetian, Jiang, Sanjie, Li, Jiankang, Zhu, Shida, Xu, Xun, Li, Fang, Liu, Zhongmin, Cao, Gang, Chen, Dongsheng
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 30.07.2021
Subjects
Brain cell atlas
Domestic pig
Neural science
Single-cell transcriptome
Single-cell transcriptome
Neural science
Domestic pig
Brain cell atlas
Online AccessGet full text
ISSN2095-9273
2095-9281
DOI10.1016/j.scib.2021.04.002

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Abstract [Display omitted] The brain of the domestic pig (Sus scrofa domesticus) has drawn considerable attention due to its high similarities to that of humans. However, the cellular compositions of the pig brain (PB) remain elusive. Here we investigated the single-nucleus transcriptomic profiles of five regions of the PB (frontal lobe, parietal lobe, temporal lobe, occipital lobe, and hypothalamus) and identified 21 cell subpopulations. The cross-species comparison of mouse and pig hypothalamus revealed the shared and specific gene expression patterns at the single-cell resolution. Furthermore, we identified cell types and molecular pathways closely associated with neurological disorders, bridging the gap between gene mutations and pathogenesis. We reported, to our knowledge, the first single-cell atlas of domestic pig cerebral cortex and hypothalamus combined with a comprehensive analysis across species, providing extensive resources for future research regarding neural science, evolutionary developmental biology, and regenerative medicine.
AbstractList [Display omitted] The brain of the domestic pig (Sus scrofa domesticus) has drawn considerable attention due to its high similarities to that of humans. However, the cellular compositions of the pig brain (PB) remain elusive. Here we investigated the single-nucleus transcriptomic profiles of five regions of the PB (frontal lobe, parietal lobe, temporal lobe, occipital lobe, and hypothalamus) and identified 21 cell subpopulations. The cross-species comparison of mouse and pig hypothalamus revealed the shared and specific gene expression patterns at the single-cell resolution. Furthermore, we identified cell types and molecular pathways closely associated with neurological disorders, bridging the gap between gene mutations and pathogenesis. We reported, to our knowledge, the first single-cell atlas of domestic pig cerebral cortex and hypothalamus combined with a comprehensive analysis across species, providing extensive resources for future research regarding neural science, evolutionary developmental biology, and regenerative medicine.
The brain of the domestic pig (Sus scrofa domesticus) has drawn considerable attention due to its high similarities to that of humans. However, the cellular compositions of the pig brain (PB) remain elusive. Here we investigated the single-nucleus transcriptomic profiles of five regions of the PB (frontal lobe, parietal lobe, temporal lobe, occipital lobe, and hypothalamus) and identified 21 cell subpopulations. The cross-species comparison of mouse and pig hypothalamus revealed the shared and specific gene expression patterns at the single-cell resolution. Furthermore, we identified cell types and molecular pathways closely associated with neurological disorders, bridging the gap between gene mutations and pathogenesis. We reported, to our knowledge, the first single-cell atlas of domestic pig cerebral cortex and hypothalamus combined with a comprehensive analysis across species, providing extensive resources for future research regarding neural science, evolutionary developmental biology, and regenerative medicine.
Author Dai, Jinxia
Wang, Shiyou
Wang, Haoyu
Tang, Gen
Xu, Xun
Zhu, Jiacheng
Cao, Gang
Luo, Lihua
Liang, Langchao
Ruan, Yetian
Wu, Weiying
Liu, Ping
Zhang, Xingliang
Qiu, Jiaying
Lin, Xiumei
Li, Fang
Zhong, Jixing
Ding, Peiwen
Zhu, Shida
Li, Jiankang
Jiang, Xiaosen
Chen, Dongsheng
Zeng, Yuying
Liu, Zhongmin
Chen, Fang
Chen, Yin
Fang, Jian
Jiang, Sanjie
Wang, Feiyue
Qiu, Xin
Sun, Chengcheng
Ding, Xiangning
Chai, Chaochao
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Issue 14
Keywords Single-cell transcriptome
Neural science
Domestic pig
Brain cell atlas
Language English
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  publication-title: Annu Rev Cell Dev Biol
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  year: 2020
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  article-title: Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons
  publication-title: Nat Neurosci
  doi: 10.1038/s41593-020-0621-y
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Snippet [Display omitted] The brain of the domestic pig (Sus scrofa domesticus) has drawn considerable attention due to its high similarities to that of humans....
The brain of the domestic pig (Sus scrofa domesticus) has drawn considerable attention due to its high similarities to that of humans. However, the cellular...
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SubjectTerms Brain cell atlas
Domestic pig
Neural science
Single-cell transcriptome
Title Single-cell atlas of domestic pig cerebral cortex and hypothalamus
URI https://dx.doi.org/10.1016/j.scib.2021.04.002
https://www.ncbi.nlm.nih.gov/pubmed/36654371
Volume 66
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