HPMA-based polymeric micelles for curcumin solubilization and inhibition of cancer cell growth

• Published in: European journal of pharmaceutics and biopharmaceutics Vol. 94; pp. 501 - 512
• Main Authors: Naksuriya, Ornchuma, Shi, Yang, van Nostrum, Cornelus F., Anuchapreeda, Songyot, Hennink, Wim E., Okonogi, Siriporn
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2015
• Subjects: Acrylamides - chemical synthesis; Acrylamides - chemistry; Acrylic Resins - chemical synthesis; Acrylic Resins - chemistry; Antineoplastic Agents, Phytogenic - administration & dosage; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; Cell Line, Tumor; Cell Survival - drug effects; Curcumin; Curcumin - administration & dosage; Curcumin - chemistry; Curcumin - pharmacology; Cytotoxicity; Drug Carriers - chemical synthesis; Drug Carriers - chemistry; Drug Compounding; Drug Liberation; Humans; Hydroxypropyl methacrylamide; Micelles; Microscopy, Electron, Transmission; Nanoparticles - chemistry; Particle Size; Polyethylene Glycols - chemical synthesis; Polyethylene Glycols - chemistry; Polymeric micelles; Solubility; Surface Properties; Cytotoxicity; Curcumin; Hydroxypropyl methacrylamide; Polymeric micelles; Solubility

[Display omitted] Curcumin (CM) has been reported as a potential anticancer agent. However, its pharmaceutical applications as therapeutic agent are hampered because of its poor aqueous solubility. The present study explores the advantages of polymeric micelles composed of block copolymers of methox...