Multicenter cross-sectional observational study of antibiotic resistance and the genotypes of Propionibacterium acnes isolated from Chinese patients with acne vulgaris

Antibiotics are widely applied in management of acne vulgaris, which raises the issue of antibiotic resistance. Due to improper application and supervision of antibiotics, antibiotic resistance has become a serious problem in China. So, the efficacy of antimicrobial therapy in acne is unclear withou...

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Published inJournal of dermatology Vol. 43; no. 4; pp. 406 - 413
Main Authors Fan, Yukun, Hao, Fei, Wang, Weizhen, Lu, Yonghong, He, Li, Wang, Gang, Chen, Wenchieh
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 01.04.2016
Wiley Subscription Services, Inc
Subjects
Acne
acne vulgaris
Acne Vulgaris - microbiology
Adolescent
Adult
Anti-Bacterial Agents - pharmacology
antibiotic resistance
Antibiotics
Child
China
Cross-Sectional Studies
Drug resistance
Drug Resistance, Multiple, Bacterial - genetics
Female
Genotype
Humans
Male
Microbial Sensitivity Tests
Propionibacterium acnes
Propionibacterium acnes - genetics
Propionibacterium acnes - isolation & purification
RNA, Bacterial - genetics
RNA, Ribosomal, 16S - genetics
RNA, Ribosomal, 23S - genetics
Young Adult
acne vulgaris
Propionibacterium acnes
antibiotic resistance
China
genotype
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Abstract Antibiotics are widely applied in management of acne vulgaris, which raises the issue of antibiotic resistance. Due to improper application and supervision of antibiotics, antibiotic resistance has become a serious problem in China. So, the efficacy of antimicrobial therapy in acne is unclear without an objective monitor of antibiotic resistance of Propionibacterium acnes. This cross‐sectional, multicenter observational study is aimed at understanding the status of antibiotic resistance in P. acnes, investigating the measures of acne management in China and analyzing the genotypes of antibiotic‐resistant strains of P. acnes. Altogether, 312 strains of P. acnes were collected from patients in five medical centers across central China after reviewing the corresponding medical history in detail. The samples underwent antibiotic susceptibility assays by agar dilution method with a total of 11 classes of antibiotics being tested. The antibiotic‐resistant strains were screened and further analyzed by investigation of the genotypes regarding 23S rRNA, 16S rRNA and erm(X). The predominant resistance occurred in macrolides and lincomycin with an overall resistance rate of 47.8%. The resistance to tetracyclines was scarce with only two cases identified. The emergence of minimum inhibitory concentration elevation for tetracyclines is associated with its application history (P < 0.005). The genotypes of the reported macrolide–lincosamide–streptogramin B resistance strains were also spotted in Chinese subjects while other resistance determinants may also exist. The tetracyclines have been proved to be vastly susceptible while macrolides and lincomycin face a serious resistance status in China.
AbstractList Antibiotics are widely applied in management of acne vulgaris, which raises the issue of antibiotic resistance. Due to improper application and supervision of antibiotics, antibiotic resistance has become a serious problem in China. So, the efficacy of antimicrobial therapy in acne is unclear without an objective monitor of antibiotic resistance of Propionibacterium acnes. This cross-sectional, multicenter observational study is aimed at understanding the status of antibiotic resistance in P. acnes, investigating the measures of acne management in China and analyzing the genotypes of antibiotic-resistant strains of P. acnes. Altogether, 312 strains of P. acnes were collected from patients in five medical centers across central China after reviewing the corresponding medical history in detail. The samples underwent antibiotic susceptibility assays by agar dilution method with a total of 11 classes of antibiotics being tested. The antibiotic-resistant strains were screened and further analyzed by investigation of the genotypes regarding 23S rRNA, 16S rRNA and erm(X). The predominant resistance occurred in macrolides and lincomycin with an overall resistance rate of 47.8%. The resistance to tetracyclines was scarce with only two cases identified. The emergence of minimum inhibitory concentration elevation for tetracyclines is associated with its application history (P < 0.005). The genotypes of the reported macrolide-lincosamide-streptogramin B resistance strains were also spotted in Chinese subjects while other resistance determinants may also exist. The tetracyclines have been proved to be vastly susceptible while macrolides and lincomycin face a serious resistance status in China.
Antibiotics are widely applied in management of acne vulgaris, which raises the issue of antibiotic resistance. Due to improper application and supervision of antibiotics, antibiotic resistance has become a serious problem in China. So, the efficacy of antimicrobial therapy in acne is unclear without an objective monitor of antibiotic resistance of Propionibacterium acnes . This cross‐sectional, multicenter observational study is aimed at understanding the status of antibiotic resistance in P. acnes , investigating the measures of acne management in China and analyzing the genotypes of antibiotic‐resistant strains of P. acnes . Altogether, 312 strains of P. acnes were collected from patients in five medical centers across central China after reviewing the corresponding medical history in detail. The samples underwent antibiotic susceptibility assays by agar dilution method with a total of 11 classes of antibiotics being tested. The antibiotic‐resistant strains were screened and further analyzed by investigation of the genotypes regarding 23S rRNA , 16S rRNA and erm(X) . The predominant resistance occurred in macrolides and lincomycin with an overall resistance rate of 47.8%. The resistance to tetracyclines was scarce with only two cases identified. The emergence of minimum inhibitory concentration elevation for tetracyclines is associated with its application history ( P < 0.005). The genotypes of the reported macrolide–lincosamide–streptogramin B resistance strains were also spotted in Chinese subjects while other resistance determinants may also exist. The tetracyclines have been proved to be vastly susceptible while macrolides and lincomycin face a serious resistance status in China.
Antibiotics are widely applied in management of acne vulgaris, which raises the issue of antibiotic resistance. Due to improper application and supervision of antibiotics, antibiotic resistance has become a serious problem in China. So, the efficacy of antimicrobial therapy in acne is unclear without an objective monitor of antibiotic resistance of Propionibacterium acnes. This cross-sectional, multicenter observational study is aimed at understanding the status of antibiotic resistance in P. acnes, investigating the measures of acne management in China and analyzing the genotypes of antibiotic-resistant strains of P. acnes. Altogether, 312 strains of P. acnes were collected from patients in five medical centers across central China after reviewing the corresponding medical history in detail. The samples underwent antibiotic susceptibility assays by agar dilution method with a total of 11 classes of antibiotics being tested. The antibiotic-resistant strains were screened and further analyzed by investigation of the genotypes regarding 23S rRNA, 16S rRNA and erm(X). The predominant resistance occurred in macrolides and lincomycin with an overall resistance rate of 47.8%. The resistance to tetracyclines was scarce with only two cases identified. The emergence of minimum inhibitory concentration elevation for tetracyclines is associated with its application history (P < 0.005). The genotypes of the reported macrolide-lincosamide-streptogramin B resistance strains were also spotted in Chinese subjects while other resistance determinants may also exist. The tetracyclines have been proved to be vastly susceptible while macrolides and lincomycin face a serious resistance status in China.Antibiotics are widely applied in management of acne vulgaris, which raises the issue of antibiotic resistance. Due to improper application and supervision of antibiotics, antibiotic resistance has become a serious problem in China. So, the efficacy of antimicrobial therapy in acne is unclear without an objective monitor of antibiotic resistance of Propionibacterium acnes. This cross-sectional, multicenter observational study is aimed at understanding the status of antibiotic resistance in P. acnes, investigating the measures of acne management in China and analyzing the genotypes of antibiotic-resistant strains of P. acnes. Altogether, 312 strains of P. acnes were collected from patients in five medical centers across central China after reviewing the corresponding medical history in detail. The samples underwent antibiotic susceptibility assays by agar dilution method with a total of 11 classes of antibiotics being tested. The antibiotic-resistant strains were screened and further analyzed by investigation of the genotypes regarding 23S rRNA, 16S rRNA and erm(X). The predominant resistance occurred in macrolides and lincomycin with an overall resistance rate of 47.8%. The resistance to tetracyclines was scarce with only two cases identified. The emergence of minimum inhibitory concentration elevation for tetracyclines is associated with its application history (P < 0.005). The genotypes of the reported macrolide-lincosamide-streptogramin B resistance strains were also spotted in Chinese subjects while other resistance determinants may also exist. The tetracyclines have been proved to be vastly susceptible while macrolides and lincomycin face a serious resistance status in China.
Author Lu, Yonghong
Wang, Weizhen
Hao, Fei
Wang, Gang
Chen, Wenchieh
He, Li
Fan, Yukun
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  surname: Hao
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  givenname: Weizhen
  surname: Wang
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  surname: Lu
  fullname: Lu, Yonghong
  organization: Department of Dermatology and Venereology, The Second People's Hospital of Chengdu, Chengdu, China
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  givenname: Wenchieh
  surname: Chen
  fullname: Chen, Wenchieh
  organization: Department of Dermatology and Allergy, Technische Universität München, Munich, Germany
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Issue 4
Keywords acne vulgaris
Propionibacterium acnes
antibiotic resistance
China
genotype
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SSID ssj0029510
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Snippet Antibiotics are widely applied in management of acne vulgaris, which raises the issue of antibiotic resistance. Due to improper application and supervision of...
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wiley
istex
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StartPage 406
SubjectTerms Acne
acne vulgaris
Acne Vulgaris - microbiology
Adolescent
Adult
Anti-Bacterial Agents - pharmacology
antibiotic resistance
Antibiotics
Child
China
Cross-Sectional Studies
Drug resistance
Drug Resistance, Multiple, Bacterial - genetics
Female
Genotype
Humans
Male
Microbial Sensitivity Tests
Propionibacterium acnes
Propionibacterium acnes - genetics
Propionibacterium acnes - isolation & purification
RNA, Bacterial - genetics
RNA, Ribosomal, 16S - genetics
RNA, Ribosomal, 23S - genetics
Young Adult
Title Multicenter cross-sectional observational study of antibiotic resistance and the genotypes of Propionibacterium acnes isolated from Chinese patients with acne vulgaris
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https://onlinelibrary.wiley.com/doi/abs/10.1111%2F1346-8138.13149
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Volume 43
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