Reversal of heart failure remodeling: Is it maintained?

• Published in: Clinical cardiology (Mahwah, N.J.) Vol. 26; no. 9; pp. 419 - 423
• Main Authors: Levine, T. Barry, Levine, Arlene B., Bolenbaugh, Janet, Green, Pamela R.
• Format: Journal Article
• Language: English
• Published: New York Wiley Periodicals, Inc 01.09.2003; Wiley
• Subjects: Adrenergic beta-Antagonists - therapeutic use; Adult; Aged; angiotensin‐converting enzyme inhibitor; beta blockers; Biological and medical sciences; Blood Pressure - physiology; Cardiomyopathies - drug therapy; Cardiomyopathies - mortality; Cardiomyopathies - physiopathology; Cardiotonic agents; Cardiovascular system; Clinical Investigation; Clinical Investigations; Echocardiography; Female; Follow-Up Studies; Heart Failure - drug therapy; Heart Failure - mortality; Heart Failure - physiopathology; heart failure remodeling; Heart Rate - physiology; Heart Ventricles - pathology; Heart Ventricles - physiopathology; Humans; Hydralazine - therapeutic use; Male; Medical sciences; Middle Aged; Mitral Valve Insufficiency - drug therapy; Mitral Valve Insufficiency - mortality; Mitral Valve Insufficiency - physiopathology; nitrates; Nitrates - therapeutic use; Pharmacology. Drug treatments; relapse; Retrospective Studies; Severity of Illness Index; Stroke Volume - physiology; Survival Analysis; Time Factors; Treatment Outcome; Vasodilation - drug effects; Vasodilation - physiology; Vasodilator Agents - therapeutic use; Ventricular Dysfunction, Left - drug therapy; Ventricular Dysfunction, Left - mortality; Ventricular Dysfunction, Left - physiopathology; Ventricular Remodeling - physiology; Cardiotonic agent; Prognosis; Vasodilator agent; Digoxin; Isosorbide; Cardiovascular disease; nitrates; beta blockers; heart failure remodeling; Vascular remodeling; Peptidyl-dipeptidase A; Heart disease; Glycoside; Left ventricle performance; Digitalis drug; Human; Heart failure; Lisinopril; Enzyme; relapse; Enzyme inhibitor; Peptidases; Chemotherapy; Treatment; Carvedilol; angiotensin-converting enzyme inhibitor; Hydrolases; Peptidyl-dipeptidases; Beta blocking agent

Background: Reversal of heart failure remodeling has been observed with intensive heart failure therapy. Hypothesis: We hypothesized that reversal of heart failure remodeling may not be sustained in long‐term follow‐up. Methods: Sixty‐one sequential patients with heart failure and left ventricular e...