Glutamate Export at the Choroid Plexus in Health, Thiamin Deficiency, and Ethanol Intoxication: Review and Hypothesis

• Published in: Alcoholism, clinical and experimental research Vol. 32; no. 8; pp. 1339 - 1349
• Main Author: Nixon, Peter F.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2008; Lippincott Williams & Wilkins
• Subjects: Alcoholic Intoxication - metabolism; Alcoholism and acute alcohol poisoning; Animals; Biological and medical sciences; Choroid Plexus; Choroid Plexus - metabolism; Disease Models, Animal; Ethanol - metabolism; Ethanol Intoxication; Eye; Glucose - metabolism; Glutamate Receptors; Glutamate Transport; Glutamates - blood; Glutamates - cerebrospinal fluid; Glutamates - metabolism; Humans; Medical sciences; Peripheral Nerves; Rats; Review and Hypothesis; Testis; Thiamin Deficiency; Thiamine Deficiency - metabolism; Toxicology; Choroid plexus; Testis; Peripheral nerve; Peripheral Nerves; Central nervous system; B-Vitamins; Glutamate receptor; Review; Testicle; Hypothesis; Eye; Visual system; Alcoholic beverage; Glutamate Receptors; Thiamin Deficiency; Thiamine; Ependymal organ; Ethanol; Health; Deficiency; Glutamate; Male genital system; Ethanol Intoxication; Glutamate Transport; Review and Hypothesis; Excitatory aminoacid; Neurotransmitter; Poisoning; Transport; Bibliographic review

Introduction:  The earliest observed effect in the pathogenesis of experimental Wernicke’s encephalopathy and of ethanol intoxication in rats is impairment of the blood cerebrospinal fluid (CSF) barrier at the choroid plexus (CP). For an explanation, these observations direct attention to the role o...