Outcomes in infants listed for liver transplantation: A retrospective cohort study using the United Network for Organ Sharing database

LT in neonates and young infants can be challenging due to a variety of factors. To describe the waitlist mortality rates and outcomes of patients listed and transplanted as infants identified from the UNOS database. Infants listed for LT between January 1985 and September 2010 were identified from...

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Published inPediatric transplantation Vol. 20; no. 7; pp. 904 - 911
Main Authors Jimenez-Rivera, Carolina, Nightingale, Scott, Benchimol, Eric I., Mazariegos, George V., Ng, Vicky L.
Format Journal Article
LanguageEnglish
Published Denmark Blackwell Publishing Ltd 01.11.2016
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Summary:LT in neonates and young infants can be challenging due to a variety of factors. To describe the waitlist mortality rates and outcomes of patients listed and transplanted as infants identified from the UNOS database. Infants listed for LT between January 1985 and September 2010 were identified from the UNOS database. Mortality on the waitlist as well as outcomes post‐LT was compared between infants aged ≤60 days (Group 1), 61–179 days (Group 2), and 180–364 days (Group 3). Of 6763 infants listed for LT (Group 1 n = 496, Group 2 n = 2404, Group 3 n = 3863), mean age at listing was 196 ± 87 days (Group 1, 29 ± 16 days; Group 2, 132 ± 32 days; Group 3, 257 ± 52 days). Waitlist mortality was highest in Group 1 (Group 1 vs. 3 HR 3.01, 95% CI 2.19–4.15, Group 2 vs. Group 3 HR 0.82, 95% CI 0.66–1.03). One‐ and five‐yr graft survival was 59.6% and 42% (Group 1), 66% and 45% (Group 2), and 66.8% and 41% (Group 3) (one‐yr survival p = 0.20; five‐yr survival p = 0.19). Infants listed for LT at age ≤60 days had greater waitlist mortality risk than older infants. Infants undergoing LT at age ≤60 days had similar rates of patient and graft survival to older infants.
Bibliography:Canadian Child Health Clinician Scientist Program
ark:/67375/WNG-RJ7C170M-K
Crohn's and Colitis Canada
Health Resources and Services Administration - No. 234-2005-370011C
Canadian Institutes of Health Research
Canadian Association of Gastroenterology
istex:B76C4D1F4BE6CAB58334064BDD3CE8A7E86A0834
ArticleID:PETR12756
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.12756