Polyomavirus (BK) in pediatric renal transplants: Evaluation of viremic patients with and without BK associated nephritis

• Published in: Pediatric transplantation Vol. 10; no. 8; pp. 920 - 922
• Main Authors: Hymes, Leonard C., Warshaw, Barry L.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2006; Blackwell
• Subjects: Adolescent; Antibodies, Viral - blood; Biological and medical sciences; Biopsy; BK virus; BK Virus - genetics; BK Virus - immunology; Child; Creatinine - blood; DNA, Viral - blood; Female; Graft Survival - immunology; Humans; Immunosuppressive Agents - therapeutic use; Kidney Transplantation - immunology; Kidney Transplantation - pathology; Male; Medical sciences; Nephritis - etiology; Nephritis - pathology; Polymerase Chain Reaction; polyoma (BK) virus; Polyomavirus; Polyomavirus Infections - complications; Polyomavirus Infections - diagnosis; renal transplant; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tumor Virus Infections - complications; Tumor Virus Infections - diagnosis; Viremia; Human; Kidney disease; Evaluation; Opportunistic infection; Pediatrics; Urinary system disease; Polyomavirus; renal transplant; Patient; Transplantation; BK virus; polyoma (BK) virus; Papovaviridae; Homotransplantation; Infection; Virus; Association; Nephropathy; Treatment; Urinary system; Surgery; Viral disease; Graft; Child

:  Polyoma BK virus (BKV) is emerging as a significant complication in renal transplantation, which may lead to renal dysfunction and graft loss caused by BK nephritis (BKN). We report the management and outcome of 20 children who developed BK viremia. Serum polymerase chain reaction (PCR) for BKV D...