Association of intercellular adhesion molecule 1 polymorphisms with retinopathy in Chinese patients with Type 2 diabetes

Aims  To investigate the relationship of the K469E and G241R polymorphisms of the intercellular adhesion molecule 1 (ICAM‐1) gene with diabetic retinopathy in Chinese patients with Type 2 diabetes mellitus. Patients and methods  One hundred and seventy‐two Chinese patients with Type 2 diabetes and 8...

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Published inDiabetic medicine Vol. 23; no. 6; pp. 643 - 648
Main Authors Liu, L., Yu, Q., Wang, H., Zhang, S. X., Huang, C., Chen, X.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.06.2006
Blackwell
Subjects
Adult
Aged
Alleles
Asian Continental Ancestry Group
Biological and medical sciences
Case-Control Studies
Chi-Square Distribution
Diabetes Mellitus, Type 2 - ethnology
Diabetes Mellitus, Type 2 - genetics
Diabetes. Impaired glucose tolerance
diabetic retinopathy
Diabetic Retinopathy - ethnology
Diabetic Retinopathy - genetics
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Genetic Predisposition to Disease
Genotype
Humans
Intercellular Adhesion Molecule-1 - genetics
Intercellular Adhesion Molecule-1 - metabolism
intercellular adhesion molecule 1
Male
Medical sciences
Middle Aged
Ophthalmology
Polymerase Chain Reaction
polymorphism
Polymorphism, Single Nucleotide
Polymorphism, Single-Stranded Conformational
Retinopathies
single-strand conformation polymorphism
Asia
China
Endocrinopathy
Type 2 diabetes
Human
Retinopathy
Genetic variability
Intercellular adhesion molecule 1
Cell adhesion molecule
Metabolic diseases
Genotype
diabetic retinopathy
single-strand conformation polymorphism
Eye disease
Chinese
Polymorphism
Online AccessGet full text
ISSN0742-3071
1464-5491
DOI10.1111/j.1464-5491.2006.01884.x

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Abstract Aims  To investigate the relationship of the K469E and G241R polymorphisms of the intercellular adhesion molecule 1 (ICAM‐1) gene with diabetic retinopathy in Chinese patients with Type 2 diabetes mellitus. Patients and methods  One hundred and seventy‐two Chinese patients with Type 2 diabetes and 80 normal control subjects were recruited. Patients with diabetes were placed into two groups: the diabetic retinopathy (DR) group and the non‐diabetic retinopathy (NDR) group. The DR group was subdivided into those with proliferative retinopathy (PDR) and non‐proliferative retinopathy (NPDR). Genomic DNA was prepared using the hydroxybenzene–chloroform extraction method. Genotypes and alleles were detected by polymerase chain reaction–heteroduplex–single‐strand conformation polymorphism (PCR–HA–SSCP) analysis combined with gene sequencing. Results  The patients with retinopathy had an increased frequency of the K469K genotype compared with both the patients without retinopathy and the control subjects (61.4 vs. 40.0 and 35.0%, respectively; χ2 = 8.280 and 13.952, respectively; P < 0.05). The frequency of the K allele in the DR group was higher than in the NDR group and control subjects (75.4 vs. 58.8 and 61.3%, respectively; χ2 = 9.693 and 11.219, respectively; P < 0.05). Genotype and allele frequencies were similar in the NDR group and control subjects, and in the PDR and NPDR groups. Conclusion  The ICAM‐1 gene K469E polymorphism is associated with diabetic retinopathy in Chinese patients with Type 2 diabetes. Patients with the K469K genotype were more likely to have diabetic retinopathy than patients with the K469E or E469E genotype. Diabet. Med. 23, 643 –648 (2006)
AbstractList To investigate the relationship of the K469E and G241R polymorphisms of the intercellular adhesion molecule 1 (ICAM-1) gene with diabetic retinopathy in Chinese patients with Type 2 diabetes mellitus. One hundred and seventy-two Chinese patients with Type 2 diabetes and 80 normal control subjects were recruited. Patients with diabetes were placed into two groups: the diabetic retinopathy (DR) group and the non-diabetic retinopathy (NDR) group. The DR group was subdivided into those with proliferative retinopathy (PDR) and non-proliferative retinopathy (NPDR). Genomic DNA was prepared using the hydroxybenzene-chloroform extraction method. Genotypes and alleles were detected by polymerase chain reaction-heteroduplex-single-strand conformation polymorphism (PCR-HA-SSCP) analysis combined with gene sequencing. The patients with retinopathy had an increased frequency of the K469K genotype compared with both the patients without retinopathy and the control subjects (61.4 vs. 40.0 and 35.0%, respectively; chi(2) = 8.280 and 13.952, respectively; P < 0.05). The frequency of the K allele in the DR group was higher than in the NDR group and control subjects (75.4 vs. 58.8 and 61.3%, respectively; chi(2) = 9.693 and 11.219, respectively; P < 0.05). Genotype and allele frequencies were similar in the NDR group and control subjects, and in the PDR and NPDR groups. The ICAM-1 gene K469E polymorphism is associated with diabetic retinopathy in Chinese patients with Type 2 diabetes. Patients with the K469K genotype were more likely to have diabetic retinopathy than patients with the K469E or E469E genotype.
Aims  To investigate the relationship of the K469E and G241R polymorphisms of the intercellular adhesion molecule 1 (ICAM‐1) gene with diabetic retinopathy in Chinese patients with Type 2 diabetes mellitus. Patients and methods  One hundred and seventy‐two Chinese patients with Type 2 diabetes and 80 normal control subjects were recruited. Patients with diabetes were placed into two groups: the diabetic retinopathy (DR) group and the non‐diabetic retinopathy (NDR) group. The DR group was subdivided into those with proliferative retinopathy (PDR) and non‐proliferative retinopathy (NPDR). Genomic DNA was prepared using the hydroxybenzene–chloroform extraction method. Genotypes and alleles were detected by polymerase chain reaction–heteroduplex–single‐strand conformation polymorphism (PCR–HA–SSCP) analysis combined with gene sequencing. Results  The patients with retinopathy had an increased frequency of the K469K genotype compared with both the patients without retinopathy and the control subjects (61.4 vs. 40.0 and 35.0%, respectively; χ2 = 8.280 and 13.952, respectively; P < 0.05). The frequency of the K allele in the DR group was higher than in the NDR group and control subjects (75.4 vs. 58.8 and 61.3%, respectively; χ2 = 9.693 and 11.219, respectively; P < 0.05). Genotype and allele frequencies were similar in the NDR group and control subjects, and in the PDR and NPDR groups. Conclusion  The ICAM‐1 gene K469E polymorphism is associated with diabetic retinopathy in Chinese patients with Type 2 diabetes. Patients with the K469K genotype were more likely to have diabetic retinopathy than patients with the K469E or E469E genotype. Diabet. Med. 23, 643 –648 (2006)
To investigate the relationship of the K469E and G241R polymorphisms of the intercellular adhesion molecule 1 (ICAM-1) gene with diabetic retinopathy in Chinese patients with Type 2 diabetes mellitus.AIMSTo investigate the relationship of the K469E and G241R polymorphisms of the intercellular adhesion molecule 1 (ICAM-1) gene with diabetic retinopathy in Chinese patients with Type 2 diabetes mellitus.One hundred and seventy-two Chinese patients with Type 2 diabetes and 80 normal control subjects were recruited. Patients with diabetes were placed into two groups: the diabetic retinopathy (DR) group and the non-diabetic retinopathy (NDR) group. The DR group was subdivided into those with proliferative retinopathy (PDR) and non-proliferative retinopathy (NPDR). Genomic DNA was prepared using the hydroxybenzene-chloroform extraction method. Genotypes and alleles were detected by polymerase chain reaction-heteroduplex-single-strand conformation polymorphism (PCR-HA-SSCP) analysis combined with gene sequencing.PATIENTS AND METHODSOne hundred and seventy-two Chinese patients with Type 2 diabetes and 80 normal control subjects were recruited. Patients with diabetes were placed into two groups: the diabetic retinopathy (DR) group and the non-diabetic retinopathy (NDR) group. The DR group was subdivided into those with proliferative retinopathy (PDR) and non-proliferative retinopathy (NPDR). Genomic DNA was prepared using the hydroxybenzene-chloroform extraction method. Genotypes and alleles were detected by polymerase chain reaction-heteroduplex-single-strand conformation polymorphism (PCR-HA-SSCP) analysis combined with gene sequencing.The patients with retinopathy had an increased frequency of the K469K genotype compared with both the patients without retinopathy and the control subjects (61.4 vs. 40.0 and 35.0%, respectively; chi(2) = 8.280 and 13.952, respectively; P < 0.05). The frequency of the K allele in the DR group was higher than in the NDR group and control subjects (75.4 vs. 58.8 and 61.3%, respectively; chi(2) = 9.693 and 11.219, respectively; P < 0.05). Genotype and allele frequencies were similar in the NDR group and control subjects, and in the PDR and NPDR groups.RESULTSThe patients with retinopathy had an increased frequency of the K469K genotype compared with both the patients without retinopathy and the control subjects (61.4 vs. 40.0 and 35.0%, respectively; chi(2) = 8.280 and 13.952, respectively; P < 0.05). The frequency of the K allele in the DR group was higher than in the NDR group and control subjects (75.4 vs. 58.8 and 61.3%, respectively; chi(2) = 9.693 and 11.219, respectively; P < 0.05). Genotype and allele frequencies were similar in the NDR group and control subjects, and in the PDR and NPDR groups.The ICAM-1 gene K469E polymorphism is associated with diabetic retinopathy in Chinese patients with Type 2 diabetes. Patients with the K469K genotype were more likely to have diabetic retinopathy than patients with the K469E or E469E genotype.CONCLUSIONThe ICAM-1 gene K469E polymorphism is associated with diabetic retinopathy in Chinese patients with Type 2 diabetes. Patients with the K469K genotype were more likely to have diabetic retinopathy than patients with the K469E or E469E genotype.
Aims  To investigate the relationship of the K469E and G241R polymorphisms of the intercellular adhesion molecule 1 (ICAM‐1) gene with diabetic retinopathy in Chinese patients with Type 2 diabetes mellitus. Patients and methods  One hundred and seventy‐two Chinese patients with Type 2 diabetes and 80 normal control subjects were recruited. Patients with diabetes were placed into two groups: the diabetic retinopathy (DR) group and the non‐diabetic retinopathy (NDR) group. The DR group was subdivided into those with proliferative retinopathy (PDR) and non‐proliferative retinopathy (NPDR). Genomic DNA was prepared using the hydroxybenzene–chloroform extraction method. Genotypes and alleles were detected by polymerase chain reaction–heteroduplex–single‐strand conformation polymorphism (PCR–HA–SSCP) analysis combined with gene sequencing. Results  The patients with retinopathy had an increased frequency of the K469K genotype compared with both the patients without retinopathy and the control subjects (61.4 vs. 40.0 and 35.0%, respectively; χ 2  = 8.280 and 13.952, respectively; P  < 0.05). The frequency of the K allele in the DR group was higher than in the NDR group and control subjects (75.4 vs. 58.8 and 61.3%, respectively; χ 2  = 9.693 and 11.219, respectively; P  < 0.05). Genotype and allele frequencies were similar in the NDR group and control subjects, and in the PDR and NPDR groups. Conclusion  The ICAM‐1 gene K469E polymorphism is associated with diabetic retinopathy in Chinese patients with Type 2 diabetes. Patients with the K469K genotype were more likely to have diabetic retinopathy than patients with the K469E or E469E genotype. Diabet. Med. 23, 643 –648 (2006)
Aims: To investigate the relationship of the K469E and G241R polymorphisms of the intercellular adhesion molecule 1 (ICAM-1) gene with diabetic retinopathy in Chinese patients with Type 2 diabetes mellitus. Patients and methods: One hundred and seventy-two Chinese patients with Type 2 diabetes and 80 normal control subjects were recruited. Patients with diabetes were placed into two groups: the diabetic retinopathy (DR) group and the non-diabetic retinopathy (NDR) group. The DR group was subdivided into those with proliferative retinopathy (PDR) and non-proliferative retinopathy (NPDR). Genomic DNA was prepared using the hydroxybenzene-chloroform extraction method. Genotypes and alleles were detected by polymerase chain reaction-heteroduplex-single-strand conformation polymorphism (PCR-HA-SSCP) analysis combined with gene sequencing. Results: The patients with retinopathy had an increased frequency of the K469K genotype compared with both the patients without retinopathy and the control subjects (61.4 vs. 40.0 and 35.0%, respectively; chi super(2) = 8.280 and 13.952, respectively; P < 0.05). The frequency of the K allele in the DR group was higher than in the NDR group and control subjects (75.4 vs. 58.8 and 61.3%, respectively; chi super(2) = 9.693 and 11.219, respectively; P < 0.05). Genotype and allele frequencies were similar in the NDR group and control subjects, and in the PDR and NPDR groups. Conclusion: The ICAM-1 gene K469E polymorphism is associated with diabetic retinopathy in Chinese patients with Type 2 diabetes. Patients with the K469K genotype were more likely to have diabetic retinopathy than patients with the K469E or E469E genotype. Diabet. Med. 23, 643 -648 (2006)
Author Yu, Q.
Wang, H.
Chen, X.
Liu, L.
Huang, C.
Zhang, S. X.
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Issue 6
Keywords Endocrinopathy
Type 2 diabetes
Human
Retinopathy
Genetic variability
Intercellular adhesion molecule 1
Cell adhesion molecule
Metabolic diseases
Genotype
diabetic retinopathy
single-strand conformation polymorphism
Eye disease
Chinese
Polymorphism
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PublicationTitle Diabetic medicine
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Kim EH, Mok JW, Bang DS, Lee ES, Lee SN, Park KS. Intercellular adhesion molecule-1 polymorphisms in Korean patients with Behcet's disease. J Korean Med Sci 2003; 18: 415-418.
Kamiuchi K, Hasegawa G, Obayashi H, Kitamura A, Ishii M, Yano M et al. Intercellular adhesion molecule-1 (ICAM-1) polymorphism is associated with diabetic retinopathy in Type 2 diabetes mellitus. Diabet Med 2002; 19: 371-376.
Joussen AM, Murata T, Tsujikawa A, Kirchhof B, Bursell SE, Adamis AP. Leukocyte-mediated endothelial cell injury and death in the diabetic retina. Am J Pathol 2001; 158: 147-152.
Adamis AP. Is diabetic retinopathy an inflammatory disease? Br J Ophthalmol 2002; 86: 363-365.
Kado S, Nagata N. Circulating intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 1999; 46: 143-148.
Ray D, Mishra M, Ralph S, Read I, Davies R, Brenchley P. Association of the VEGF gene with proliferative diabetic retinopathy but not proteinuria in diabetes. Diabetes 2004; 53: 861-864.
Barile GR, Chang SS, Park LS, Reppucci VS, Schiff WM, Schmidt AM. Soluble cellular adhesion molecules in proliferative vitreoretinopathy and proliferative diabetic retinopathy. Curr Eye Res 1999; 19: 219-227.
Barouch FC, Miyamoto K, Allport JR, Fujita K, Bursell SE, Aiello LP et al. Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. Invest Ophthalmol Vis Sci 2000; 41: 1153-1158.
Heidenkummer HP, Kampik A. Intercellular adhesion molecule-1 (ICAM-1) and leukocyte function-associated antigen-1 (LFA-1) expression in human epiretinal membranes. Graefes Arch Clin Exp Ophthalmol 1992; 230: 483-487.
Joussen AM, Poulaki V, Le ML, Koizumi K, Esser C, Janicki H et al. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J 2004; 18: 1450-1452.
Nishimura M, Obayashi H, Maruya E, Ohta M, Tegoshi H, Fukui M et al. Association between type 1 diabetes age-at-onset and intercellular adhesion molecule-1 (ICAM-1) gene polymorphism. Hum Immunol 2000; 61: 507-510.
Steidl U, Haas R, Kronenwett R. Intercellular adhesion molecular 1 on monocytes mediates adhesion as well as trans-endothelial migration and can be downregulated using antisense oligonucleotides. Ann Hematol 2000; 79: 414-423.
Ponthieux A, Lambert D, Herbeth B, Droesch S, Pfister M, Visvikis S. Association between Gly241Arg ICAM-1 gene polymorphism and serum sICAM-1 concentration in the Stanislas cohort. Eur J Hum Genet 2003; 11: 679-686.
Matsumoto A, Iwashima Y, Abiko A, Morikawa A, Sekiguchi M, Eto M et al. Detection of the association between a deletion polymorphism in the gene encoding angiotensin I-converting enzyme and advanced diabetic retinopathy. Diabetes Res Clin Pract 2000; 50: 195-202.
Nejentsev S, Guja C, McCormack R, Cooper J, Howson JM, Nutland S et al. Association of intercellular adhesion molecule-1 gene with type 1 diabetes. Lancet 2003; 362: 1723-1724.
Kretowski A, Wawrusiewicz N, Mironczuk K. Intercellular adhesion molecule 1 gene polymorphisms in Graves' disease. J Clin Endocrinol Metab 2003; 88: 4945-4949.
Carman CV, Jun CD, Salas A. Endothelial cells proactively form microvilli-like membrane projections upon intercellular adhesion molecule 1 engagement of leukocyte LFA-1. J Immunol 2003; 171: 6135-6144.
Joussen AM, Poulaki V, Qin W, Kirchhof B, Mitsiades N, Wiegand SJ et al. Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo. Am J Pathol 2002; 160: 501-509.
Papa A, Danese S, Urgesi R, Grillo A, Guglielmo S, Roberto I et al. Intercellular adhesion molecule 1 gene polymorphisms in inflammatory bowel disease. Eur Rev Med Pharmacol Sci 2004; 8: 187-191.
Olmos P, Futers S, Acosta AM. (AC)23[Z-2] polymorphism of the aldose reductase gene and fast progression of retinopathy in Chilean type 2 diabetics. Diabetes Res Clin Pract 2000; 47: 169-176.
Warpeha KM, Chakravarthy U. Molecular genetics of microvascular disease in diabetic retinopathy. Eye 2003; 17: 305-311.
Beranek M, Kankova K, Benes P, Izakovicova-Holla L, Znojil V, Hajek D et al. Polymorphism R25P in the gene encoding transforming growth factor-β (TGF-β1) is a newly identified risk factor for proliferative diabetic retinopathy. Am J Med Genet 2002; 109: 278-283.
Kumaramanickavel G, Sripriya S, Vellanki RN, Upadyay NK, Badrinath SS, Rajendran V et al. Inducible nitric oxide synthase gene and diabetic retinopathy in Asian Indian patients. Clin Genet 2002; 61: 344-348.
Zhao H, Zhuang F, Stoltz JF. Comparative studies of LFA-1/ICAM−1 interaction by micropipette and flow chamber techniques. Biorheology 2003; 40: 179-187.
He Z, King GL. Microvascular complications of diabetes. Endocrinol Metab Clin North Am 2004; 33: 215-238.
Miller J, Knorr R, Ferrone M, Houdei R, Carron CP, Dustin ML. Intercellular adhesion molecule-1 dimerization and its consequences for adhesion mediated by lymphocyte function associated-1. J Exp Med 1995; 182: 1231-1241.
Auer J, Weber T, Berent R, Lassnig E, Lamm G, Eber B. Genetic polymorphisms in cytokine and adhesion molecule genes in coronary artery disease. Am J Pharmacogenomics 2003; 3: 317-328.
Aiello LM. Perspectives on diabetic retinopathy. Am J Ophthalmol 2003; 136: 122-135.
Bai N, Tang S, Ma J, Luo Y, Lin S. Increased expression of intercellular adhesion molecule-1, vascular cellular adhesion molecule-1 and leukocyte common antigen in diabetic rat retina. Yan Ke Xue Bao 2003; 19: 176-183.
Miyamoto K, Khosrof S, Bursell SE, Rohan R, Murata T, Clermont AC et al. Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proc Natl Acad Sci USA 1999; 96: 10836-10841.
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References_xml – reference: Kumaramanickavel G, Sripriya S, Vellanki RN, Upadyay NK, Badrinath SS, Rajendran V et al. Inducible nitric oxide synthase gene and diabetic retinopathy in Asian Indian patients. Clin Genet 2002; 61: 344-348.
– reference: Beranek M, Kankova K, Benes P, Izakovicova-Holla L, Znojil V, Hajek D et al. Polymorphism R25P in the gene encoding transforming growth factor-β (TGF-β1) is a newly identified risk factor for proliferative diabetic retinopathy. Am J Med Genet 2002; 109: 278-283.
– reference: Adamis AP. Is diabetic retinopathy an inflammatory disease? Br J Ophthalmol 2002; 86: 363-365.
– reference: Nishimura M, Obayashi H, Maruya E, Ohta M, Tegoshi H, Fukui M et al. Association between type 1 diabetes age-at-onset and intercellular adhesion molecule-1 (ICAM-1) gene polymorphism. Hum Immunol 2000; 61: 507-510.
– reference: Olmos P, Futers S, Acosta AM. (AC)23[Z-2] polymorphism of the aldose reductase gene and fast progression of retinopathy in Chilean type 2 diabetics. Diabetes Res Clin Pract 2000; 47: 169-176.
– reference: Steidl U, Haas R, Kronenwett R. Intercellular adhesion molecular 1 on monocytes mediates adhesion as well as trans-endothelial migration and can be downregulated using antisense oligonucleotides. Ann Hematol 2000; 79: 414-423.
– reference: Miller J, Knorr R, Ferrone M, Houdei R, Carron CP, Dustin ML. Intercellular adhesion molecule-1 dimerization and its consequences for adhesion mediated by lymphocyte function associated-1. J Exp Med 1995; 182: 1231-1241.
– reference: Zhao H, Zhuang F, Stoltz JF. Comparative studies of LFA-1/ICAM−1 interaction by micropipette and flow chamber techniques. Biorheology 2003; 40: 179-187.
– reference: Aiello LM. Perspectives on diabetic retinopathy. Am J Ophthalmol 2003; 136: 122-135.
– reference: Ponthieux A, Lambert D, Herbeth B, Droesch S, Pfister M, Visvikis S. Association between Gly241Arg ICAM-1 gene polymorphism and serum sICAM-1 concentration in the Stanislas cohort. Eur J Hum Genet 2003; 11: 679-686.
– reference: Sans E, Delachanal E, Duperray A. Analysis of the roles of ICAM-1 in neutrophil transmigration using a reconstituted mammalian cell expression model: implication of ICAM-1 cytoplasmic domain and Rho-dependent signaling pathway. J Immunol 2001; 166: 544-551.
– reference: Joussen AM, Poulaki V, Qin W, Kirchhof B, Mitsiades N, Wiegand SJ et al. Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo. Am J Pathol 2002; 160: 501-509.
– reference: Kim EH, Mok JW, Bang DS, Lee ES, Lee SN, Park KS. Intercellular adhesion molecule-1 polymorphisms in Korean patients with Behcet's disease. J Korean Med Sci 2003; 18: 415-418.
– reference: He Z, King GL. Microvascular complications of diabetes. Endocrinol Metab Clin North Am 2004; 33: 215-238.
– reference: Papa A, Danese S, Urgesi R, Grillo A, Guglielmo S, Roberto I et al. Intercellular adhesion molecule 1 gene polymorphisms in inflammatory bowel disease. Eur Rev Med Pharmacol Sci 2004; 8: 187-191.
– reference: Auer J, Weber T, Berent R, Lassnig E, Lamm G, Eber B. Genetic polymorphisms in cytokine and adhesion molecule genes in coronary artery disease. Am J Pharmacogenomics 2003; 3: 317-328.
– reference: Kado S, Nagata N. Circulating intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 1999; 46: 143-148.
– reference: Kretowski A, Wawrusiewicz N, Mironczuk K. Intercellular adhesion molecule 1 gene polymorphisms in Graves' disease. J Clin Endocrinol Metab 2003; 88: 4945-4949.
– reference: Kamiuchi K, Hasegawa G, Obayashi H, Kitamura A, Ishii M, Yano M et al. Intercellular adhesion molecule-1 (ICAM-1) polymorphism is associated with diabetic retinopathy in Type 2 diabetes mellitus. Diabet Med 2002; 19: 371-376.
– reference: Miyamoto K, Khosrof S, Bursell SE, Rohan R, Murata T, Clermont AC et al. Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proc Natl Acad Sci USA 1999; 96: 10836-10841.
– reference: Matsumoto A, Iwashima Y, Abiko A, Morikawa A, Sekiguchi M, Eto M et al. Detection of the association between a deletion polymorphism in the gene encoding angiotensin I-converting enzyme and advanced diabetic retinopathy. Diabetes Res Clin Pract 2000; 50: 195-202.
– reference: Heidenkummer HP, Kampik A. Intercellular adhesion molecule-1 (ICAM-1) and leukocyte function-associated antigen-1 (LFA-1) expression in human epiretinal membranes. Graefes Arch Clin Exp Ophthalmol 1992; 230: 483-487.
– reference: Carman CV, Jun CD, Salas A. Endothelial cells proactively form microvilli-like membrane projections upon intercellular adhesion molecule 1 engagement of leukocyte LFA-1. J Immunol 2003; 171: 6135-6144.
– reference: Joussen AM, Murata T, Tsujikawa A, Kirchhof B, Bursell SE, Adamis AP. Leukocyte-mediated endothelial cell injury and death in the diabetic retina. Am J Pathol 2001; 158: 147-152.
– reference: Ray D, Mishra M, Ralph S, Read I, Davies R, Brenchley P. Association of the VEGF gene with proliferative diabetic retinopathy but not proteinuria in diabetes. Diabetes 2004; 53: 861-864.
– reference: Bai N, Tang S, Ma J, Luo Y, Lin S. Increased expression of intercellular adhesion molecule-1, vascular cellular adhesion molecule-1 and leukocyte common antigen in diabetic rat retina. Yan Ke Xue Bao 2003; 19: 176-183.
– reference: Joussen AM, Poulaki V, Le ML, Koizumi K, Esser C, Janicki H et al. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J 2004; 18: 1450-1452.
– reference: Nejentsev S, Guja C, McCormack R, Cooper J, Howson JM, Nutland S et al. Association of intercellular adhesion molecule-1 gene with type 1 diabetes. Lancet 2003; 362: 1723-1724.
– reference: Barile GR, Chang SS, Park LS, Reppucci VS, Schiff WM, Schmidt AM. Soluble cellular adhesion molecules in proliferative vitreoretinopathy and proliferative diabetic retinopathy. Curr Eye Res 1999; 19: 219-227.
– reference: Barouch FC, Miyamoto K, Allport JR, Fujita K, Bursell SE, Aiello LP et al. Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. Invest Ophthalmol Vis Sci 2000; 41: 1153-1158.
– reference: Warpeha KM, Chakravarthy U. Molecular genetics of microvascular disease in diabetic retinopathy. Eye 2003; 17: 305-311.
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SSID ssj0012939
Score 1.9317464
Snippet Aims  To investigate the relationship of the K469E and G241R polymorphisms of the intercellular adhesion molecule 1 (ICAM‐1) gene with diabetic retinopathy in...
Aims  To investigate the relationship of the K469E and G241R polymorphisms of the intercellular adhesion molecule 1 (ICAM‐1) gene with diabetic retinopathy in...
To investigate the relationship of the K469E and G241R polymorphisms of the intercellular adhesion molecule 1 (ICAM-1) gene with diabetic retinopathy in...
Aims: To investigate the relationship of the K469E and G241R polymorphisms of the intercellular adhesion molecule 1 (ICAM-1) gene with diabetic retinopathy in...
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Enrichment Source
Publisher
StartPage 643
SubjectTerms Adult
Aged
Alleles
Asian Continental Ancestry Group
Biological and medical sciences
Case-Control Studies
Chi-Square Distribution
Diabetes Mellitus, Type 2 - ethnology
Diabetes Mellitus, Type 2 - genetics
Diabetes. Impaired glucose tolerance
diabetic retinopathy
Diabetic Retinopathy - ethnology
Diabetic Retinopathy - genetics
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Genetic Predisposition to Disease
Genotype
Humans
Intercellular Adhesion Molecule-1 - genetics
Intercellular Adhesion Molecule-1 - metabolism
intercellular adhesion molecule 1
Male
Medical sciences
Middle Aged
Ophthalmology
Polymerase Chain Reaction
polymorphism
Polymorphism, Single Nucleotide
Polymorphism, Single-Stranded Conformational
Retinopathies
single-strand conformation polymorphism
Title Association of intercellular adhesion molecule 1 polymorphisms with retinopathy in Chinese patients with Type 2 diabetes
URI https://api.istex.fr/ark:/67375/WNG-K92HWKVP-6/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1464-5491.2006.01884.x
https://www.ncbi.nlm.nih.gov/pubmed/16759306
https://www.proquest.com/docview/19439012
https://www.proquest.com/docview/68044077
Volume 23
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