Human hair follicle epithelium has an antimicrobial defence system that includes the inducible antimicrobial peptide psoriasin (S100A7) and RNase 7

• Published in: British journal of dermatology (1951) Vol. 161; no. 1; pp. 78 - 89
• Main Authors: Reithmayer, K., Meyer, K.C., Kleditzsch, P., Tiede, S., Uppalapati, S.K., Gläser, R., Harder, J., Schröder, J.-M., Paus, R.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2009; Wiley-Blackwell
• Subjects: Aged; antimicrobial peptides; Biological and medical sciences; Calcium-Binding Proteins - metabolism; Dermatology; Epithelium - immunology; Epithelium - metabolism; Female; Hair Follicle - drug effects; Hair Follicle - immunology; Hair Follicle - metabolism; human hair follicle; Humans; Immunohistochemistry; Interferon-gamma - pharmacology; Lipopolysaccharides - pharmacology; Medical sciences; Middle Aged; psoriasin; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleases - metabolism; RNA, Messenger - analysis; S100 Calcium Binding Protein A7; S100 Proteins; S100A7; Toll-Like Receptor 4 - metabolism; Up-Regulation - drug effects; Human; Peptides; Dermatology; human hair follicle, psoriasin; Hair follicle; Epithelium; Antimicrobial agent; antimicrobial peptides; S100A7

Summary Background  Hair follicle (HF) ostia represent a potential port of microbial entry into the skin. However, they rarely show clinical signs of infection. This suggests the presence of local, efficient, antimicrobial defence systems, which may include antimicrobial peptides (AMPs). Objectives ...