Competitive inhibition of the 5-lipoxygenase-catalysed linoleate oxidation by arachidonic and 5-hydroperoxy-eicosatetraenoic acids

Linoleic and arachidonic acids are competing substrates for 5-1ipoxygenase from barley. When these two substrates are added simultaneously, arachidonic acid acts as a competitive inhibitor of linoleic acid oxidation with K i of 20 μM, the same value as the Michaelis constant for arachidonate oxygena...

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Bibliographic Details
Published inFEBS letters Vol. 377; no. 3; pp. 306 - 308
Main Authors Mirzoeva, Olga K., Sud'ina, Galina F., Pushkareva, Marina A., Varfolomeev, Sergey D.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 27.12.1995
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