Choroid Plexus Dysfunction: The Initial Event in the Pathogenesis of Wernicke's Encephalopathy and Ethanol Intoxication

• Published in: Alcoholism, clinical and experimental research Vol. 32; no. 8; pp. 1513 - 1523
• Main Authors: Nixon, Peter F., Jordan, Lindsay, Zimitat, Craig, Rose, Stephen E., Zelaya, Fernando
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2008; Lippincott Williams & Wilkins
• Subjects: Alcoholic Intoxication - etiology; Alcoholic Intoxication - physiopathology; Alcoholism and acute alcohol poisoning; Animals; Biological and medical sciences; Blood-Brain Barrier - drug effects; Central Nervous System Depressants - pharmacology; Choroid Plexus; Choroid Plexus - drug effects; Choroid Plexus - pathology; Choroid Plexus - physiopathology; Contrast-Enhanced MRI; Disease Models, Animal; Dizocilpine Maleate - pharmacology; Dose-Response Relationship, Drug; Ethanol - pharmacology; Ethanol Intoxication; Female; Glucose - metabolism; Glucose - pharmacology; Magnetic Resonance Imaging; Medical sciences; Neuroprotective Agents - pharmacology; Rat; Rats; Rats, Wistar; Thiamin Deficiency; Thiamine Deficiency - metabolism; Toxicology; Wernicke Encephalopathy - etiology; Wernicke Encephalopathy - physiopathology; Wernicke's Encephalopathy; Choroid plexus; Rat; Pathogenesis; Central nervous system; B-Vitamins; Alcoholic beverage; Encephalopathy; Thiamin Deficiency; Thiamine; Contrast-Enhanced MRI; Ependymal organ; Nervous system diseases; Ethanol; Deficiency; Rodentia; Wernicke's Encephalopathy; Contrast; Nuclear magnetic resonance imaging; Cerebral disorder; Ethanol Intoxication; Vertebrata; Mammalia; Dysfunction; Animal; Central nervous system disease; Poisoning

Background:  In both acute ethanol intoxication and in thiamin deficient glucose metabolism, previous studies have detected blood‐brain barrier (BBB) and/or blood‐CSF‐barrier (BCSFB) impairment but were unable to assess their significance in relation to other changes in the brain. Methods:  Contrast...