Circulating interleukin-10 and interleukin-12 in Parkinson's disease

• Published in: Acta neurologica Scandinavica Vol. 119; no. 5; pp. 332 - 337
• Main Authors: Rentzos, M., Nikolaou, C., Andreadou, E., Paraskevas, G. P., Rombos, A., Zoga, M., Tsoutsou, A., Boufidou, F., Kapaki, E., Vassilopoulos, D.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.2009; Blackwell
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Biomarkers - analysis; Biomarkers - blood; Chemotaxis, Leukocyte - immunology; Cytoprotection - immunology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; ELISA; Encephalitis - blood; Encephalitis - immunology; Encephalitis - physiopathology; Female; Gliosis - blood; Gliosis - immunology; Gliosis - physiopathology; Humans; IL-10; IL-12; Immune Tolerance - immunology; immunological disturbances; Interleukin-10 - analysis; Interleukin-10 - blood; Interleukin-12 - analysis; Interleukin-12 - blood; l-dopa treatment; Male; Medical sciences; Middle Aged; Neurology; Parkinson Disease - blood; Parkinson Disease - immunology; Parkinson Disease - physiopathology; Parkinson's disease; Phagocytes - immunology; Predictive Value of Tests; Serum; Up-Regulation - immunology; Nervous system diseases; Parkinson's disease; Cytokine; Parkinson disease; Interleukin 12; IL-12; L-dopa treatment; IL-10; Cerebral disorder; immunological disturbances; Treatment; Central nervous system disease; Interleukin 10; Serum; Degenerative disease; Dopa; ELISA assay; Extrapyramidal syndrome; ELISA

Background –  Interleukin (IL)‐12 is a heterodimeric cytokine produced by activated blood monocytes, macrophages and glial cells. It enhances differentiation and proliferation of T cells and increases production of proinflammatory cytokines. IL‐10 is a pleiotropic cytokine produced by both lymphocyt...