Circulating interleukin-10 and interleukin-12 in Parkinson's disease
Background – Interleukin (IL)‐12 is a heterodimeric cytokine produced by activated blood monocytes, macrophages and glial cells. It enhances differentiation and proliferation of T cells and increases production of proinflammatory cytokines. IL‐10 is a pleiotropic cytokine produced by both lymphocyt...
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| Published in | Acta neurologica Scandinavica Vol. 119; no. 5; pp. 332 - 337 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.05.2009
Blackwell |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Background – Interleukin (IL)‐12 is a heterodimeric cytokine produced by activated blood monocytes, macrophages and glial cells. It enhances differentiation and proliferation of T cells and increases production of proinflammatory cytokines. IL‐10 is a pleiotropic cytokine produced by both lymphocytes and mononuclear phagocytes including microglia. Recent studies demonstrated the neuroprotective effect of IL‐10. There is little information about the involvement of IL‐12 or IL‐10 in the pathophysiology of Parkinson’s disease (PD).
Objectives – The objective of our study was to assess the role of IL‐12 as a potential marker of immune reactions in patients with PD and to investigate whether IL‐10, an immunosuppressive cytokine, may have a neuroprotective effect in the pathogenesis of PD.
Patients and methods – We measured using immunoassay serum IL‐12 and IL‐10 levels in 41 patients with PD in comparison with serum levels in 19 healthy subjects (controls) age and sex matched. IL‐12 and IL‐10 levels were tested for correlation with sex, age, disease duration, Hoehn and Yahr stage and the UPDRS III score.
Results – The PD group presented with significantly increased IL‐10 levels when compared with the control group (P = 0.02). The increase observed was not affected by the treatment status. A strong and significant correlation between IL‐10 and IL‐12 levels was observed in patients with PD (RS = 0.7, P < 0.000001).
Conclusions – Our findings suggest that IL‐10 may be involved in the pathogenetic mechanisms of PD. The elevation of IL‐10 and the significant correlation between IL‐10 and IL‐12, a proinflammatory cytokine, may suggest that immunological disturbances and neuroprotective mechanisms are involved in patients with PD. |
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| AbstractList | Interleukin (IL)-12 is a heterodimeric cytokine produced by activated blood monocytes, macrophages and glial cells. It enhances differentiation and proliferation of T cells and increases production of proinflammatory cytokines. IL-10 is a pleiotropic cytokine produced by both lymphocytes and mononuclear phagocytes including microglia. Recent studies demonstrated the neuroprotective effect of IL-10. There is little information about the involvement of IL-12 or IL-10 in the pathophysiology of Parkinson's disease (PD).BACKGROUNDInterleukin (IL)-12 is a heterodimeric cytokine produced by activated blood monocytes, macrophages and glial cells. It enhances differentiation and proliferation of T cells and increases production of proinflammatory cytokines. IL-10 is a pleiotropic cytokine produced by both lymphocytes and mononuclear phagocytes including microglia. Recent studies demonstrated the neuroprotective effect of IL-10. There is little information about the involvement of IL-12 or IL-10 in the pathophysiology of Parkinson's disease (PD).The objective of our study was to assess the role of IL-12 as a potential marker of immune reactions in patients with PD and to investigate whether IL-10, an immunosuppressive cytokine, may have a neuroprotective effect in the pathogenesis of PD.OBJECTIVESThe objective of our study was to assess the role of IL-12 as a potential marker of immune reactions in patients with PD and to investigate whether IL-10, an immunosuppressive cytokine, may have a neuroprotective effect in the pathogenesis of PD.We measured using immunoassay serum IL-12 and IL-10 levels in 41 patients with PD in comparison with serum levels in 19 healthy subjects (controls) age and sex matched. IL-12 and IL-10 levels were tested for correlation with sex, age, disease duration, Hoehn and Yahr stage and the UPDRS III score.PATIENTS AND METHODSWe measured using immunoassay serum IL-12 and IL-10 levels in 41 patients with PD in comparison with serum levels in 19 healthy subjects (controls) age and sex matched. IL-12 and IL-10 levels were tested for correlation with sex, age, disease duration, Hoehn and Yahr stage and the UPDRS III score.The PD group presented with significantly increased IL-10 levels when compared with the control group (P = 0.02). The increase observed was not affected by the treatment status. A strong and significant correlation between IL-10 and IL-12 levels was observed in patients with PD (R(S) = 0.7, P < 0.000001).RESULTSThe PD group presented with significantly increased IL-10 levels when compared with the control group (P = 0.02). The increase observed was not affected by the treatment status. A strong and significant correlation between IL-10 and IL-12 levels was observed in patients with PD (R(S) = 0.7, P < 0.000001).Our findings suggest that IL-10 may be involved in the pathogenetic mechanisms of PD. The elevation of IL-10 and the significant correlation between IL-10 and IL-12, a proinflammatory cytokine, may suggest that immunological disturbances and neuroprotective mechanisms are involved in patients with PD.CONCLUSIONSOur findings suggest that IL-10 may be involved in the pathogenetic mechanisms of PD. The elevation of IL-10 and the significant correlation between IL-10 and IL-12, a proinflammatory cytokine, may suggest that immunological disturbances and neuroprotective mechanisms are involved in patients with PD. Rentzos M, Nikolaou C, Andreadou E, Paraskevas GP, Rombos A, Zoga M, Tsoutsou A, Boufidou F, Kapaki E, Vassilopoulos D. Circulating interleukin-10 and interleukin-12 in Parkinson's disease.Acta Neurol Scand: DOI: 2009: 119: 332-337[copy ] 2008 The Authors Journal compilation [copy ] 2008 Blackwell Munksgaard.Background - Interleukin (IL)-12 is a heterodimeric cytokine produced by activated blood monocytes, macrophages and glial cells. It enhances differentiation and proliferation of T cells and increases production of proinflammatory cytokines. IL-10 is a pleiotropic cytokine produced by both lymphocytes and mononuclear phagocytes including microglia. Recent studies demonstrated the neuroprotective effect of IL-10. There is little information about the involvement of IL-12 or IL-10 in the pathophysiology of Parkinson's disease (PD).Objectives - The objective of our study was to assess the role of IL-12 as a potential marker of immune reactions in patients with PD and to investigate whether IL-10, an immunosuppressive cytokine, may have a neuroprotective effect in the pathogenesis of PD.Patients and methods - We measured using immunoassay serum IL-12 and IL-10 levels in 41 patients with PD in comparison with serum levels in 19 healthy subjects (controls) age and sex matched. IL-12 and IL-10 levels were tested for correlation with sex, age, disease duration, Hoehn and Yahr stage and the UPDRS III score.Results - The PD group presented with significantly increased IL-10 levels when compared with the control group (P = 0.02). The increase observed was not affected by the treatment status. A strong and significant correlation between IL-10 and IL-12 levels was observed in patients with PD (RS = 0.7, P < 0.000001).Conclusions - Our findings suggest that IL-10 may be involved in the pathogenetic mechanisms of PD. The elevation of IL-10 and the significant correlation between IL-10 and IL-12, a proinflammatory cytokine, may suggest that immunological disturbances and neuroprotective mechanisms are involved in patients with PD. Background – Interleukin (IL)‐12 is a heterodimeric cytokine produced by activated blood monocytes, macrophages and glial cells. It enhances differentiation and proliferation of T cells and increases production of proinflammatory cytokines. IL‐10 is a pleiotropic cytokine produced by both lymphocytes and mononuclear phagocytes including microglia. Recent studies demonstrated the neuroprotective effect of IL‐10. There is little information about the involvement of IL‐12 or IL‐10 in the pathophysiology of Parkinson’s disease (PD). Objectives – The objective of our study was to assess the role of IL‐12 as a potential marker of immune reactions in patients with PD and to investigate whether IL‐10, an immunosuppressive cytokine, may have a neuroprotective effect in the pathogenesis of PD. Patients and methods – We measured using immunoassay serum IL‐12 and IL‐10 levels in 41 patients with PD in comparison with serum levels in 19 healthy subjects (controls) age and sex matched. IL‐12 and IL‐10 levels were tested for correlation with sex, age, disease duration, Hoehn and Yahr stage and the UPDRS III score. Results – The PD group presented with significantly increased IL‐10 levels when compared with the control group (P = 0.02). The increase observed was not affected by the treatment status. A strong and significant correlation between IL‐10 and IL‐12 levels was observed in patients with PD (RS = 0.7, P < 0.000001). Conclusions – Our findings suggest that IL‐10 may be involved in the pathogenetic mechanisms of PD. The elevation of IL‐10 and the significant correlation between IL‐10 and IL‐12, a proinflammatory cytokine, may suggest that immunological disturbances and neuroprotective mechanisms are involved in patients with PD. Interleukin (IL)-12 is a heterodimeric cytokine produced by activated blood monocytes, macrophages and glial cells. It enhances differentiation and proliferation of T cells and increases production of proinflammatory cytokines. IL-10 is a pleiotropic cytokine produced by both lymphocytes and mononuclear phagocytes including microglia. Recent studies demonstrated the neuroprotective effect of IL-10. There is little information about the involvement of IL-12 or IL-10 in the pathophysiology of Parkinson's disease (PD). The objective of our study was to assess the role of IL-12 as a potential marker of immune reactions in patients with PD and to investigate whether IL-10, an immunosuppressive cytokine, may have a neuroprotective effect in the pathogenesis of PD. We measured using immunoassay serum IL-12 and IL-10 levels in 41 patients with PD in comparison with serum levels in 19 healthy subjects (controls) age and sex matched. IL-12 and IL-10 levels were tested for correlation with sex, age, disease duration, Hoehn and Yahr stage and the UPDRS III score. The PD group presented with significantly increased IL-10 levels when compared with the control group (P = 0.02). The increase observed was not affected by the treatment status. A strong and significant correlation between IL-10 and IL-12 levels was observed in patients with PD (R(S) = 0.7, P < 0.000001). Our findings suggest that IL-10 may be involved in the pathogenetic mechanisms of PD. The elevation of IL-10 and the significant correlation between IL-10 and IL-12, a proinflammatory cytokine, may suggest that immunological disturbances and neuroprotective mechanisms are involved in patients with PD. |
| Author | Paraskevas, G. P. Tsoutsou, A. Andreadou, E. Vassilopoulos, D. Kapaki, E. Zoga, M. Rentzos, M. Nikolaou, C. Rombos, A. Boufidou, F. |
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| Keywords | Nervous system diseases Parkinson's disease Cytokine Parkinson disease Interleukin 12 IL-12 L-dopa treatment IL-10 Cerebral disorder immunological disturbances Treatment Central nervous system disease Interleukin 10 Serum Degenerative disease Dopa ELISA assay Extrapyramidal syndrome ELISA |
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| References_xml | – reference: Bachis A, Colangelo AM, Vicini S et al. Interleukin-10 prevents glutamate-mediated cerebellar granule cell death by blocking caspase-3-like activity. J Neurosci 2001;21:3104-12. – reference: Qian L, Hong JS, Flood PM. Role of microglia in inflammation-mediated degeneration of dopaminergic neurons: neuroprotective effect of interleukin-10. J Neural Transm Suppl 2006;70:367-71. – reference: Rieckmann P, Albrecht M, Kitze B et al. Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis. Neurology 1994;44:1523-6. – reference: Williams K, Dooley N, Ulvestad E et al. IL-10 production by adult human derived microglial cells. Neurochem Int 1996;96:55-64. – reference: Rentzos M, Nikolaou C, Andreadou E et al. Circulating interleukin-15 and RANTES chemokine in Parkinson's disease. Acta Neurol Scand 2007;116:374-9. – reference: ΑRimoto T, Choi DY, Lu X et al. Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra. Neurobiol Aging 2006;28:894-906. – reference: Jason J, Archibald LK, Nwanyanwu OC et al. Comparison of serum and cell-specific cytokines in humans. Clin Diagn Lab Immunol 2001;8:1097-103. – reference: Marques CP, Hu S, Sheng W et al. Interleukin-10 attenuates production of HSV-induced inflammatory mediators by human microglia. Glia 2004;47:358-66. – reference: Mesples B, Plaisant F, Gressens P. Effects of interleukin-10 on neonatal excitotoxic brain lesions in mice. Brain Res Dev Brain Res 2003;141:25-32. – reference: Mogi M, Harada M, Kondo T et al. Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from Parkinsonian patients. Neurosci Lett 1994;180:147-50. – reference: Boka G, Anglade P, Wallach D et al. Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease. 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and chemokine production in primary murine microglia and a human monocyte cell line publication-title: J Neuroimmunol – volume: 17 start-page: 97 year: 1995 end-page: 105 article-title: Tumor necrosis factor‐alpha production by human fetal microglial cells: regulation by other cytokines publication-title: Dev Neurosci – volume: 89 start-page: 242 year: 1994 end-page: 51 article-title: Clinical diagnosis of Parkinson’s disease. 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| Snippet | Background – Interleukin (IL)‐12 is a heterodimeric cytokine produced by activated blood monocytes, macrophages and glial cells. It enhances differentiation... Interleukin (IL)-12 is a heterodimeric cytokine produced by activated blood monocytes, macrophages and glial cells. It enhances differentiation and... Rentzos M, Nikolaou C, Andreadou E, Paraskevas GP, Rombos A, Zoga M, Tsoutsou A, Boufidou F, Kapaki E, Vassilopoulos D. Circulating interleukin-10 and... |
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| SubjectTerms | Aged Aged, 80 and over Biological and medical sciences Biomarkers - analysis Biomarkers - blood Chemotaxis, Leukocyte - immunology Cytoprotection - immunology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ELISA Encephalitis - blood Encephalitis - immunology Encephalitis - physiopathology Female Gliosis - blood Gliosis - immunology Gliosis - physiopathology Humans IL-10 IL-12 Immune Tolerance - immunology immunological disturbances Interleukin-10 - analysis Interleukin-10 - blood Interleukin-12 - analysis Interleukin-12 - blood l-dopa treatment Male Medical sciences Middle Aged Neurology Parkinson Disease - blood Parkinson Disease - immunology Parkinson Disease - physiopathology Parkinson's disease Phagocytes - immunology Predictive Value of Tests Serum Up-Regulation - immunology |
| Title | Circulating interleukin-10 and interleukin-12 in Parkinson's disease |
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