Asthma Associated Cytokines Regulate the Expression of SARS-CoV-2 Receptor ACE2 in the Lung Tissue of Asthmatic Patients

• Published in: Frontiers in immunology Vol. 12; p. 796094
• Main Authors: Saheb Sharif-Askari, Fatemeh, Goel, Swati, Saheb Sharif-Askari, Narjes, Hafezi, Shirin, Al Heialy, Saba, Hachim, Mahmood Yaseen, Hachim, Ibrahim Yaseen, Mahboub, Bassam, Salameh, Laila, Abdelrazig, Mawada, Elzain, Eman Ibrahim, Al-Muhsen, Saleh, Al-Hajjaj, Mohamed S., Ratemi, Elaref, Hamid, Qutayba, Halwani, Rabih
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 17.01.2022
• Subjects: ACE2; Adult; Angiotensin-Converting Enzyme 2 - immunology; asthma; Asthma - immunology; COVID-19; COVID-19 - immunology; cytokines; Cytokines - immunology; Female; Gene Expression Regulation - immunology; Humans; Immunology; Lung - immunology; Male; Middle Aged; SARS-CoV-2; SARS-CoV-2 - immunology; Serine Endopeptidases - immunology; TMPRSS2; COVID-19; ACE2; SARS-CoV-2; IL-19; IL-17; TMPRSS2; asthma; cytokines

It is still controversial whether chronic lung inflammation increases the risk for COVID-19. One of the risk factors for acquiring COVID-19 is the level of expression of SARS-CoV-2 entry receptors, ACE2 and TMPRSS2, in lung tissue. It is, however, not clear how lung tissue inflammation affects expre...