Ablation of Neutral Cholesterol Ester Hydrolase 1 Accelerates Atherosclerosis

• Published in: Cell metabolism Vol. 10; no. 3; pp. 219 - 228
• Main Authors: Sekiya, Motohiro, Osuga, Jun-ichi, Nagashima, Shuichi, Ohshiro, Taichi, Igarashi, Masaki, Okazaki, Hiroaki, Takahashi, Manabu, Tazoe, Fumiko, Wada, Taeko, Ohta, Keisuke, Takanashi, Mikio, Kumagai, Masayoshi, Nishi, Makiko, Takase, Satoru, Yahagi, Naoya, Yagyu, Hiroaki, Ohashi, Ken, Nagai, Ryozo, Kadowaki, Takashi, Furukawa, Yusuke, Ishibashi, Shun
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2009
• Subjects: Animals; Apolipoproteins E - deficiency; Apolipoproteins E - genetics; Apolipoproteins E - metabolism; Atherosclerosis - etiology; Atherosclerosis - pathology; Cholesterol - metabolism; Cholesterol Esters - metabolism; Foam Cells - cytology; Foam Cells - metabolism; Gene Knockdown Techniques; HUMDISEASE; Male; Mice; Mice, Knockout; RNA Interference; Serine Proteases - genetics; Serine Proteases - physiology; Sterol Esterase - genetics; Sterol Esterase - physiology; HUMDISEASE

Cholesterol ester (CE)-laden macrophage foam cells are the hallmark of atherosclerosis, and the hydrolysis of intracellular CE is one of the key steps in foam cell formation. Although hormone-sensitive lipase (LIPE) and cholesterol ester hydrolase (CEH), which is identical to carboxylsterase 1 (CES1...