Immune Checkpoint LAG3 and Its Ligand FGL1 in Cancer

• Published in: Frontiers in immunology Vol. 12; p. 785091
• Main Authors: Shi, An-Ping, Tang, Xi-Yang, Xiong, Yan-Lu, Zheng, Kai-Fu, Liu, Yu-Jian, Shi, Xian-Gui, Lv, Yao, Jiang, Tao, Ma, Nan, Zhao, Jin-Bo
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 17.01.2022
• Subjects: Animals; Antigens, CD - immunology; Antineoplastic Agents, Immunological - immunology; FGL1; Fibrinogen - immunology; Humans; immune checkpoint; immune response; immune therapy; Immunology; LAG3; Ligands; Neoplasms - immunology; tumor; Tumor Microenvironment - immunology; LAG3; immune therapy; immune response; FGL1; tumor; immune checkpoint

LAG3 is the most promising immune checkpoint next to PD-1 and CTLA-4. High LAG3 and FGL1 expression boosts tumor growth by inhibiting the immune microenvironment. This review comprises four sections presenting the structure/expression, interaction, biological effects, and clinical application of LAG...