Polyfunctional Fc Dependent Activity of Antibodies to Native Trimeric Envelope in HIV Elite Controllers

• Published in: Frontiers in immunology Vol. 11; p. 583820
• Main Authors: Kant, Sanket, Zhang, Ningyu, Barbé, Alexandre, Routy, Jean-Pierre, Tremblay, Cécile, Thomas, Réjean, Szabo, Jason, Côté, Pierre, Trottier, Benoit, LeBlanc, Roger, Rouleau, Danielle, Harris, Marianne, Dupuy, Franck P., Bernard, Nicole F.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 30.09.2020
• Subjects: ADCC; antibody dependent functions; Elite controllers; HIV; HIV reservoir; HIV+ plasma; Immunology; HIV; HIV envelope conformation; HIV+ plasma; antibody dependent functions; HIV reservoir; ADCC; Viral controllers; Elite controllers

Antibody dependent (AD) functions such as AD cellular cytotoxicity (ADCC) were associated with lower viral load (VL) in untreated HIV progressors and protection from HIV infection in the modestly protective RV144 HIV vaccine trial. Target cells used to measure ADCC, AD complement deposition (ADCD),...