Breathing Abnormalities During Sleep and Wakefulness in Rett Syndrome: Clinical Relevance and Paradoxical Relationship With Circulating Pro-oxidant Markers

• Published in: Frontiers in neurology Vol. 13; p. 833239
• Main Authors: Leoncini, Silvia, Signorini, Cinzia, Boasiako, Lidia, Scandurra, Valeria, Hayek, Joussef, Ciccoli, Lucia, Rossi, Marcello, Canitano, Roberto, De Felice, Claudio
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 29.03.2022
• Subjects: Neurology; non-protein-bound iron; oxidative stress; respiratory dysfunction; Rett syndrome; sleep-wakefulness cycle; non-protein-bound iron; oxidative stress; respiratory dysfunction; Rett syndrome; sleep-wakefulness cycle

Breathing abnormalities are common in Rett syndrome (RTT), a pervasive neurodevelopmental disorder almost exclusively affecting females. RTT is linked to mutations in the methyl-CpG-binding protein 2 ( ) gene. Our aim was to assess the clinical relevance of apneas during sleep-wakefulness cycle in a...