Assessment of Ultra-Early Administration of Sacubitril Valsartan to Improve Cardiac Remodeling in Patients With Acute Myocardial Infarction Following Primary PCI: Rational and Design of a Prospective, Multicenter, Randomized Controlled Trial

• Published in: Frontiers in physiology Vol. 13; p. 831212
• Main Authors: Li, Zhengwei, Fu, Guosheng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 10.02.2022
• Subjects: acute myocardial infarction; cardiac remodeling; cardiothoracic ratio (CTR); echocardiographic measurement; NT pro-BNP; Physiology; sacubitril valsartan; NT pro-BNP; echocardiographic measurement; sacubitril valsartan; acute myocardial infarction; cardiothoracic ratio (CTR); cardiac remodeling

Despite coronary re-vascularization, the common complications of acute myocardial infarction (AMI), cardiac remodeling, and heart failure (HF), is increasing globally. Sacubitril valsartan (SV), an angiotensin receptor-neprilysin inhibitor (ARNI), has been previously demonstrated to improve HF. We f...