IL-10R Polymorphisms Are Associated with Very-early-onset Ulcerative Colitis

• Published in: Inflammatory bowel diseases Vol. 19; no. 1; pp. 115 - 123
• Main Authors: Moran, Christopher J., Walters, Thomas D., Guo, Cong-Hui, Kugathasan, Subra, Klein, Christoph, Turner, Dan, Wolters, Victorien M., Bandsma, Robert H., Mouzaki, Marialena, Zachos, Mary, Langer, Jacob C., Cutz, Ernest, Benseler, Susanne M., Roifman, Chaim M., Silverberg, Mark S., Griffiths, Anne M., Snapper, Scott B., Muise, Aleixo M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford University Press 01.01.2013
• Subjects: Adolescent; Age of Onset; Case-Control Studies; Child; Child, Preschool; Cohort Studies; Colitis, Ulcerative - genetics; Crohn Disease - genetics; Female; Follow-Up Studies; Genetic Association Studies; Genetic Predisposition to Disease - genetics; Humans; Infant; Infant, Newborn; Inflammatory bowel disease; Interleukin-10 - metabolism; Interleukin-10 Receptor alpha Subunit - genetics; Interleukin-10 Receptor beta Subunit - genetics; Mutation; Mutation - genetics; Phosphorylation; Polymorphism, Single Nucleotide - genetics; Prognosis; RNA Splice Sites - genetics; STAT3 Transcription Factor - metabolism; immunodeficiency; IL-10 receptor; IL-10; inflammatory bowel disease

Interleukin-10 (IL-10) signaling genes are attractive inflammatory bowel disease (IBD) candidate genes as IL-10 restricts intestinal inflammation, IL-10 polymorphisms have been associated with IBD in genome-wide association studies, and mutations in IL-10 and IL-10 receptor (IL-10R) genes have been...