Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer

• Published in: Carcinogenesis (New York) Vol. 31; no. 9; pp. 1509 - 1515
• Main Author: Igal, R. A.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.09.2010
• Subjects: Animals; Apoptosis; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Chemical agents; Humans; Medical sciences; Neoplasms - enzymology; Neoplasms - pathology; Stearoyl-CoA Desaturase - physiology; Tumors; Cell proliferation; Enzyme; Cell death; Stearoyl-CoA desaturase; Oxidoreductases; Malignant tumor; Mechanism of action; Cell transformation; Carcinogenesis; Apoptosis; Cancer

As part of a shift toward macromolecule production to support continuous cell proliferation, cancer cells coordinate the activation of lipid biosynthesis and the signaling networks that stimulate this process. A ubiquitous metabolic event in cancer is the constitutive activation of the fatty acid bi...