Early Screening and Risk Factors of Autism Spectrum Disorder in a Large Cohort of Chinese Patients With Prader-Willi Syndrome

Previous studies regarding the prevalence of Autism Spectrum Disorder (ASD) in patients with Prader-Willi Syndrome (PWS) have implicated heterogenous findings. Additionally, the early screening of ASD high-risk population for ASD and identifying ASD risk factors in PWS patients have not been explore...

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Published inFrontiers in psychiatry Vol. 11; p. 594934
Main Authors Kong, Xuejun, Zhu, Junli, Tian, Ruiyi, Liu, Siyu, Sherman, Hannah T, Zhang, Xiaoying, Lin, Xiaojing, Han, Yan, Xiang, Zhi, Koh, Madelyn, Hobbie, Clara, Wang, Bryan, Liu, Kevin, Liu, Jun, Yin, Yueping, Wan, Guobin
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 26.11.2020
Subjects
autism like phenotype (ALP)
Autism Spectrum Disorder (ASD)
height
Prader-Willi Syndrome (PWS)
Psychiatry
weight
Prader-Willi Syndrome (PWS)
autism like phenotype (ALP)
Autism Spectrum Disorder (ASD)
weight
height
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Abstract Previous studies regarding the prevalence of Autism Spectrum Disorder (ASD) in patients with Prader-Willi Syndrome (PWS) have implicated heterogenous findings. Additionally, the early screening of ASD high-risk population for ASD and identifying ASD risk factors in PWS patients have not been explored. This study included 218 Chinese PWS patients aged 3 months to 18 years old. 78% of subjects were identified as high risk for ASD by ASQ-3 Communication domain score for those younger than 3 years of age and 84% of subjects were classified as high risk for ASD by the GARS-3 for those aged 3 years and older. Among PWS clinical measurements, under-height ( = 0.0186), overweight ( = 0.0248), and obstructive sleep apnea ( = 0.0259) were each significantly correlated with ASD risk. These risk factors and their internal relationship with ASD or ASD traits warrant further studies.
AbstractList Previous studies regarding the prevalence of Autism Spectrum Disorder (ASD) in patients with Prader-Willi Syndrome (PWS) have implicated heterogenous findings. Additionally, the early screening of ASD high-risk population for ASD and identifying ASD risk factors in PWS patients have not been explored. This study included 218 Chinese PWS patients aged 3 months to 18 years old. 78% of subjects were identified as high risk for ASD by ASQ-3 Communication domain score for those younger than 3 years of age and 84% of subjects were classified as high risk for ASD by the GARS-3 for those aged 3 years and older. Among PWS clinical measurements, under-height (P = 0.0186), overweight (P = 0.0248), and obstructive sleep apnea (P = 0.0259) were each significantly correlated with ASD risk. These risk factors and their internal relationship with ASD or ASD traits warrant further studies.
Previous studies regarding the prevalence of Autism Spectrum Disorder (ASD) in patients with Prader-Willi Syndrome (PWS) have implicated heterogenous findings. Additionally, the early screening of ASD high-risk population for ASD and identifying ASD risk factors in PWS patients have not been explored. This study included 218 Chinese PWS patients aged 3 months to 18 years old. 78% of subjects were identified as high risk for ASD by ASQ-3 Communication domain score for those younger than 3 years of age and 84% of subjects were classified as high risk for ASD by the GARS-3 for those aged 3 years and older. Among PWS clinical measurements, under-height ( P = 0.0186), overweight ( P = 0.0248), and obstructive sleep apnea ( P = 0.0259) were each significantly correlated with ASD risk. These risk factors and their internal relationship with ASD or ASD traits warrant further studies.
Previous studies regarding the prevalence of Autism Spectrum Disorder (ASD) in patients with Prader-Willi Syndrome (PWS) have implicated heterogenous findings. Additionally, the early screening of ASD high-risk population for ASD and identifying ASD risk factors in PWS patients have not been explored. This study included 218 Chinese PWS patients aged 3 months to 18 years old. 78% of subjects were identified as high risk for ASD by ASQ-3 Communication domain score for those younger than 3 years of age and 84% of subjects were classified as high risk for ASD by the GARS-3 for those aged 3 years and older. Among PWS clinical measurements, under-height ( = 0.0186), overweight ( = 0.0248), and obstructive sleep apnea ( = 0.0259) were each significantly correlated with ASD risk. These risk factors and their internal relationship with ASD or ASD traits warrant further studies.
Author Tian, Ruiyi
Lin, Xiaojing
Wan, Guobin
Wang, Bryan
Xiang, Zhi
Zhang, Xiaoying
Hobbie, Clara
Liu, Kevin
Yin, Yueping
Sherman, Hannah T
Zhu, Junli
Liu, Siyu
Liu, Jun
Kong, Xuejun
Koh, Madelyn
Han, Yan
AuthorAffiliation 2 Fisher College , Boston, MA , United States
3 Hangzhou Seventh People's Hospital , Hangzhou , China
8 Shenzhen Maternity & Child Healthcare Hospital , Shenzhen , China
1 Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital , Charlestown, MA , United States
6 Carleton College , Northfield, MI , United States
5 Institute of Dermatology and Hospital for Skin Disease, Chinese Academy of Medical Science and Peking Union Medical College , Nanjing , China
4 Prader-Willi Syndrome Care and Support Center , Hangzhou , China
7 Brandeis University , Waltham, MA , United States
AuthorAffiliation_xml – name: 1 Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital , Charlestown, MA , United States
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– sequence: 16
  givenname: Guobin
  surname: Wan
  fullname: Wan, Guobin
  organization: Shenzhen Maternity & Child Healthcare Hospital, Shenzhen, China
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Copyright Copyright © 2020 Kong, Zhu, Tian, Liu, Sherman, Zhang, Lin, Han, Xiang, Koh, Hobbie, Wang, Liu, Liu, Yin and Wan.
Copyright © 2020 Kong, Zhu, Tian, Liu, Sherman, Zhang, Lin, Han, Xiang, Koh, Hobbie, Wang, Liu, Liu, Yin and Wan. 2020 Kong, Zhu, Tian, Liu, Sherman, Zhang, Lin, Han, Xiang, Koh, Hobbie, Wang, Liu, Liu, Yin and Wan
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Keywords Prader-Willi Syndrome (PWS)
autism like phenotype (ALP)
Autism Spectrum Disorder (ASD)
weight
height
Language English
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This article was submitted to Child and Adolescent Psychiatry, a section of the journal Frontiers in Psychiatry
Reviewed by: Isabelle Esther Bauer, University of Texas Health Science Center at Houston, United States; Munis Dundar, Erciyes University, Turkey
Edited by: Christian P. Schaaf, Heidelberg University, Germany
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Snippet Previous studies regarding the prevalence of Autism Spectrum Disorder (ASD) in patients with Prader-Willi Syndrome (PWS) have implicated heterogenous findings....
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SubjectTerms autism like phenotype (ALP)
Autism Spectrum Disorder (ASD)
height
Prader-Willi Syndrome (PWS)
Psychiatry
weight
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Title Early Screening and Risk Factors of Autism Spectrum Disorder in a Large Cohort of Chinese Patients With Prader-Willi Syndrome
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