Experimental rhinovirus challenges in adults with mild asthma: Response to infection in relation to IgE

• Published in: Journal of allergy and clinical immunology Vol. 111; no. 5; pp. 1008 - 1016
• Main Authors: Zambrano, Juan C., Carper, Holliday T., Rakes, Gary P., Patrie, James, Murphy, Deborah D., Platts-Mills, Thomas A.E., Hayden, Frederick G., Gwaltney, Jack M., Hatley, Tina K., Owens, Angela M., Heymann, Peter W.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.05.2003; Elsevier; Elsevier Limited
• Subjects: Adolescent; Adult; allergic inflammation; Asthma; Asthma - immunology; Biological and medical sciences; Blood Proteins - analysis; Chronic obstructive pulmonary disease, asthma; Common Cold; eosinophil cationic protein; Eosinophil Granule Proteins; eosinophils; expired nitric oxide; Female; Human viral diseases; Humans; IgE; Immunoglobulin E - blood; Infectious diseases; Intercellular Adhesion Molecule-1 - analysis; intracellular adhesion molecule-1; Lung - physiopathology; Male; Medical sciences; Nasal Mucosa - chemistry; Nitric Oxide - biosynthesis; Picornaviridae Infections - etiology; Picornaviridae Infections - immunology; Pneumology; Rhinovirus; Ribonucleases; Viral diseases; Viral diseases of the respiratory system and ent viral diseases; viral infections; viral infections; allergic inflammation; eosinophil cationic protein; IgE; intracellular adhesion molecule-1; eosinophils; expired nitric oxide; rhinovirus; Asthma; Immunopathology; Allergy; Intercellular adhesion molecule 1; Respiratory disease; Picornaviridae; Granulocyte; Inflammation; Eosinophil; Virus; Infection; Nitric oxide; Obstructive pulmonary disease; Eosinophil cationic protein; Rhinovirus

Although most children and young adults with asthma are atopic, exacerbations of asthma are frequently associated with viral respiratory tract infections, especially those caused by rhinovirus (HRV). Young atopic adults with mild asthma were evaluated before and during an experimental HRV infection...