Experimental rhinovirus challenges in adults with mild asthma: Response to infection in relation to IgE

Although most children and young adults with asthma are atopic, exacerbations of asthma are frequently associated with viral respiratory tract infections, especially those caused by rhinovirus (HRV). Young atopic adults with mild asthma were evaluated before and during an experimental HRV infection...

Full description

Saved in:
Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 111; no. 5; pp. 1008 - 1016
Main Authors Zambrano, Juan C., Carper, Holliday T., Rakes, Gary P., Patrie, James, Murphy, Deborah D., Platts-Mills, Thomas A.E., Hayden, Frederick G., Gwaltney, Jack M., Hatley, Tina K., Owens, Angela M., Heymann, Peter W.
Format Journal Article
LanguageEnglish
Published New York, NY Mosby, Inc 01.05.2003
Elsevier
Elsevier Limited
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Although most children and young adults with asthma are atopic, exacerbations of asthma are frequently associated with viral respiratory tract infections, especially those caused by rhinovirus (HRV). Young atopic adults with mild asthma were evaluated before and during an experimental HRV infection to test the hypothesis that airway inflammation before virus inoculation may be a risk factor for an adverse response to HRV. Experimental HRV infections were evaluated in 16 allergic volunteers with mild asthma and 9 nonatopic control patients (age, 18 to 30 years). Before virus inoculation, each participant was screened with tests for lung function, prick skin tests for sensitization to common aeroallergens, measurements of total serum IgE, and serum neutralizing antibody to rhinovirus-16 (the serotype used for inoculation). The response to infection was monitored for 21 days by using symptom diary cards, tests for lung function, and markers of airway inflammation in nasal washes, blood, and expired air. During the infection, asthmatic patients had cumulative upper and lower respiratory tract symptom scores that were significantly greater over the course of 21 days than scores from the control patients. At baseline, the asthmatic patients also had increased sensitivity to methacholine and significantly lower values for FEV1 (percent predicted) than the control patients (geometric mean and intraquartile values: 87% [79% to 91%] for the asthmatic patients and 101% [90% to 104%] for the control patients, P<.03). Among the patients with mild asthma, 6 had levels of total serum IgE that were substantially elevated (range, 371 to 820 IU/mL). Those with high levels of IgE had significantly greater lower respiratory tract symptom scores during the initial 4 days of the infection than the low IgE group. They also had higher total blood eosinophil counts at baseline, increased eosinophil cationic protein in their nasal washes (>200 ng/mL), and augmented levels of expired nitric oxide at baseline and during peak cold symptoms. In contrast, levels of soluble intracellular adhesion molecule-1 in nasal wash supernatants from the asthmatic patients with high IgE were diminished, both at baseline and during the infection. The reduced lung function and increased markers of inflammation observed before virus inoculation in the asthmatic patients who had high levels of total serum IgE may be risk factors for an adverse response to infections with HRV.
AbstractList Although most children and young adults with asthma are atopic, exacerbations of asthma are frequently associated with viral respiratory tract infections, especially those caused by rhinovirus (HRV). Young atopic adults with mild asthma were evaluated before and during an experimental HRV infection to test the hypothesis that airway inflammation before virus inoculation may be a risk factor for an adverse response to HRV. Experimental HRV infections were evaluated in 16 allergic volunteers with mild asthma and 9 nonatopic control patients (age, 18 to 30 years). Before virus inoculation, each participant was screened with tests for lung function, prick skin tests for sensitization to common aeroallergens, measurements of total serum IgE, and serum neutralizing antibody to rhinovirus-16 (the serotype used for inoculation). The response to infection was monitored for 21 days by using symptom diary cards, tests for lung function, and markers of airway inflammation in nasal washes, blood, and expired air. During the infection, asthmatic patients had cumulative upper and lower respiratory tract symptom scores that were significantly greater over the course of 21 days than scores from the control patients. At baseline, the asthmatic patients also had increased sensitivity to methacholine and significantly lower values for FEV1 (percent predicted) than the control patients (geometric mean and intraquartile values: 87% [79% to 91%] for the asthmatic patients and 101% [90% to 104%] for the control patients, P<.03). Among the patients with mild asthma, 6 had levels of total serum IgE that were substantially elevated (range, 371 to 820 IU/mL). Those with high levels of IgE had significantly greater lower respiratory tract symptom scores during the initial 4 days of the infection than the low IgE group. They also had higher total blood eosinophil counts at baseline, increased eosinophil cationic protein in their nasal washes (>200 ng/mL), and augmented levels of expired nitric oxide at baseline and during peak cold symptoms. In contrast, levels of soluble intracellular adhesion molecule-1 in nasal wash supernatants from the asthmatic patients with high IgE were diminished, both at baseline and during the infection. The reduced lung function and increased markers of inflammation observed before virus inoculation in the asthmatic patients who had high levels of total serum IgE may be risk factors for an adverse response to infections with HRV.
Background: Although most children and young adults with asthma are atopic, exacerbations of asthma are frequently associated with viral respiratory tract infections, especially those caused by rhinovirus (HRV). Objective: Young atopic adults with mild asthma were evaluated before and during an experimental HRV infection to test the hypothesis that airway inflammation before virus inoculation may be a risk factor for an adverse response to HRV. Methods: Experimental HRV infections were evaluated in 16 allergic volunteers with mild asthma and 9 nonatopic control patients (age, 18 to 30 years). Before virus inoculation, each participant was screened with tests for lung function, prick skin tests for sensitization to common aeroallergens, measurements of total serum IgE, and serum neutralizing antibody to rhinovirus-16 (the serotype used for inoculation). The response to infection was monitored for 21 days by using symptom diary cards, tests for lung function, and markers of airway inflammation in nasal washes, blood, and expired air. Results: During the infection, asthmatic patients had cumulative upper and lower respiratory tract symptom scores that were significantly greater over the course of 21 days than scores from the control patients. At baseline, the asthmatic patients also had increased sensitivity to methacholine and significantly lower values for FEV1(percent predicted) than the control patients (geometric mean and intraquartile values: 87% [79% to 91%] for the asthmatic patients and 101% [90% to 104%] for the control patients,P<.03). Among the patients with mild asthma, 6 had levels of total serum IgE that were substantially elevated (range, 371 to 820 IU/mL). Those with high levels of IgE had significantly greater lower respiratory tract symptom scores during the initial 4 days of the infection than the low IgE group. They also had higher total blood eosinophil counts at baseline, increased eosinophil cationic protein in their nasal washes (>200 ng/mL), and augmented levels of expired nitric oxide at baseline and during peak cold symptoms. In contrast, levels of soluble intracellular adhesion molecule-1 in nasal wash supernatants from the asthmatic patients with high IgE were diminished, both at baseline and during the infection. Conclusions: The reduced lung function and increased markers of inflammation observed before virus inoculation in the asthmatic patients who had high levels of total serum IgE may be risk factors for an adverse response to infections with HRV.
Although most children and young adults with asthma are atopic, exacerbations of asthma are frequently associated with viral respiratory tract infections, especially those caused by rhinovirus (HRV). Young atopic adults with mild asthma were evaluated before and during an experimental HRV infection to test the hypothesis that airway inflammation before virus inoculation may be a risk factor for an adverse response to HRV. Experimental HRV infections were evaluated in 16 allergic volunteers with mild asthma and 9 nonatopic control patients (age, 18 to 30 years). Before virus inoculation, each participant was screened with tests for lung function, prick skin tests for sensitization to common aeroallergens, measurements of total serum IgE, and serum neutralizing antibody to rhinovirus-16 (the serotype used for inoculation). The response to infection was monitored for 21 days by using symptom diary cards, tests for lung function, and markers of airway inflammation in nasal washes, blood, and expired air. During the infection, asthmatic patients had cumulative upper and lower respiratory tract symptom scores that were significantly greater over the course of 21 days than scores from the control patients. At baseline, the asthmatic patients also had increased sensitivity to methacholine and significantly lower values for FEV(1) (percent predicted) than the control patients (geometric mean and intraquartile values: 87% [79% to 91%] for the asthmatic patients and 101% [90% to 104%] for the control patients, P <.03). Among the patients with mild asthma, 6 had levels of total serum IgE that were substantially elevated (range, 371 to 820 IU/mL) compared with 10 who had lower levels (range, 29 to 124 IU/mL). Those with high levels of IgE had significantly greater lower respiratory tract symptom scores during the initial 4 days of the infection than the low IgE group. They also had higher total blood eosinophil counts at baseline, increased eosinophil cationic protein in their nasal washes (>200 ng/mL), and augmented levels of expired nitric oxide at baseline and during peak cold symptoms. In contrast, levels of soluble intracellular adhesion molecule-1 in nasal wash supernatants from the asthmatic patients with high IgE were diminished, both at baseline and during the infection. The reduced lung function and increased markers of inflammation observed before virus inoculation in the asthmatic patients who had high levels of total serum IgE may be risk factors for an adverse response to infections with HRV.
BACKGROUNDAlthough most children and young adults with asthma are atopic, exacerbations of asthma are frequently associated with viral respiratory tract infections, especially those caused by rhinovirus (HRV).OBJECTIVEYoung atopic adults with mild asthma were evaluated before and during an experimental HRV infection to test the hypothesis that airway inflammation before virus inoculation may be a risk factor for an adverse response to HRV.METHODSExperimental HRV infections were evaluated in 16 allergic volunteers with mild asthma and 9 nonatopic control patients (age, 18 to 30 years). Before virus inoculation, each participant was screened with tests for lung function, prick skin tests for sensitization to common aeroallergens, measurements of total serum IgE, and serum neutralizing antibody to rhinovirus-16 (the serotype used for inoculation). The response to infection was monitored for 21 days by using symptom diary cards, tests for lung function, and markers of airway inflammation in nasal washes, blood, and expired air.RESULTSDuring the infection, asthmatic patients had cumulative upper and lower respiratory tract symptom scores that were significantly greater over the course of 21 days than scores from the control patients. At baseline, the asthmatic patients also had increased sensitivity to methacholine and significantly lower values for FEV(1) (percent predicted) than the control patients (geometric mean and intraquartile values: 87% [79% to 91%] for the asthmatic patients and 101% [90% to 104%] for the control patients, P <.03). Among the patients with mild asthma, 6 had levels of total serum IgE that were substantially elevated (range, 371 to 820 IU/mL) compared with 10 who had lower levels (range, 29 to 124 IU/mL). Those with high levels of IgE had significantly greater lower respiratory tract symptom scores during the initial 4 days of the infection than the low IgE group. They also had higher total blood eosinophil counts at baseline, increased eosinophil cationic protein in their nasal washes (>200 ng/mL), and augmented levels of expired nitric oxide at baseline and during peak cold symptoms. In contrast, levels of soluble intracellular adhesion molecule-1 in nasal wash supernatants from the asthmatic patients with high IgE were diminished, both at baseline and during the infection.CONCLUSIONSThe reduced lung function and increased markers of inflammation observed before virus inoculation in the asthmatic patients who had high levels of total serum IgE may be risk factors for an adverse response to infections with HRV.
Although most children and young adults with asthma are atopic, exacerbations of asthma are frequently associated with viral respiratory tract infections, especially those caused by rhinovirus (HRV). Objective: Young atopic adults with mild asthma were evaluated before and during an experimental HRV infection to test the hypothesis that airway inflammation before virus inoculation may be a risk factor for an adverse response to HRV. Methods: Experimental HRV infections were evaluated in 16 allergic volunteers with mild asthma and 9 nonatopic control patients (age, 18 to 30 years). Before virus inoculation, each participant was screened with tests for lung function, prick skin tests for sensitization to common aeroallergens, measurements of total serum IgE, and serum neutralizing antibody to rhinovirus-16 (the serotype used for inoculation). The response to infection was monitored for 21 days by using symptom diary cards, tests for lung function, and markers of airway inflammation in nasal washes, blood, and expired air. Results: During the infection, asthmatic patients had cumulative upper and lower respiratory tract symptom scores that were significantly greater over the course of 21 days than scores from the control patients. At baseline, the asthmatic patients also had increased sensitivity to methacholine and significantly lower values for FEV sub(1) (percent predicted) than the control patients (geometric mean and intraquartile values: 87% [79% to 91%] for the asthmatic patients and 101% [90% to 104%] for the control patients, P < .03). Among the patients with mild asthma, 6 had levels of total serum IgE that were substantially elevated (range, 371 to 820 IU/mL) compared with 10 who had lower levels (range, 29 to 124 IU/mL). Those with high levels of IgE had significantly greater lower respiratory tract symptom scores during the initial 4 days of the infection than the low IgE group. They also had higher total blood eosinophil counts at baseline, increased eosinophil cationic protein in their nasal washes (>200 ng/mL), and augmented levels of expired nitric oxide at baseline and during peak cold symptoms. In contrast, levels of soluble intracellular adhesion molecule-1 in nasal wash supernatants from the asthmatic patients with high IgE were diminished, both at baseline and during the infection. Conclusions: The reduced lung function and increased markers of inflammation observed before virus inoculation in the asthmatic patients who had high levels of total serum IgE may be risk factors for an adverse response to infections with HRV.
Author Rakes, Gary P.
Gwaltney, Jack M.
Platts-Mills, Thomas A.E.
Heymann, Peter W.
Patrie, James
Hayden, Frederick G.
Hatley, Tina K.
Zambrano, Juan C.
Carper, Holliday T.
Murphy, Deborah D.
Owens, Angela M.
Author_xml – sequence: 1
  givenname: Juan C.
  surname: Zambrano
  fullname: Zambrano, Juan C.
  organization: Department of Pediatrics University of Virginia Health System USA
– sequence: 2
  givenname: Holliday T.
  surname: Carper
  fullname: Carper, Holliday T.
  organization: Department of Pediatrics University of Virginia Health System USA
– sequence: 3
  givenname: Gary P.
  surname: Rakes
  fullname: Rakes, Gary P.
  organization: Department of Pediatrics University of Virginia Health System USA
– sequence: 4
  givenname: James
  surname: Patrie
  fullname: Patrie, James
  organization: Department of Health Evaluation Sciences University of Virginia Health System USA
– sequence: 5
  givenname: Deborah D.
  surname: Murphy
  fullname: Murphy, Deborah D.
  organization: Department of Pediatrics University of Virginia Health System USA
– sequence: 6
  givenname: Thomas A.E.
  surname: Platts-Mills
  fullname: Platts-Mills, Thomas A.E.
  organization: Department of Internal Medicine, University of Virginia Health System USA
– sequence: 7
  givenname: Frederick G.
  surname: Hayden
  fullname: Hayden, Frederick G.
  organization: Department of Internal Medicine, University of Virginia Health System USA
– sequence: 8
  givenname: Jack M.
  surname: Gwaltney
  fullname: Gwaltney, Jack M.
  organization: Department of Internal Medicine, University of Virginia Health System USA
– sequence: 9
  givenname: Tina K.
  surname: Hatley
  fullname: Hatley, Tina K.
  organization: Department of Pediatrics University of Virginia Health System USA
– sequence: 10
  givenname: Angela M.
  surname: Owens
  fullname: Owens, Angela M.
  organization: Department of Pediatrics University of Virginia Health System USA
– sequence: 11
  givenname: Peter W.
  surname: Heymann
  fullname: Heymann, Peter W.
  organization: Department of Pediatrics University of Virginia Health System USA
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14797897$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/12743565$$D View this record in MEDLINE/PubMed
BookMark eNqF0dGLFCEcB3CJi25v67HXGIh6m01HR8fejmOrg4Mg6lkc_bnr4eimM1f997ntwkEQPan48af-vlfoIqYICL0keEMwF-8m7TcdxnRDqORP0IpgKVo-dP0FWmEsScsFk5foqpR7XNd0kM_QJekEoz3vV2i3_XmA7CeIsw5N3vuYHnxeSmP2OgSIOyiNj422S5hL88PP-2bywTa6zPtJv2--QDmkWKCZU3UOzOxTPJ7IEPSfed243W2fo6dOhwIvzuMaffuw_Xrzqb37_PH25vquNYz3c-vIKKjuDNEj5s7AIIUYJWZ04JrwXgPtrbEMOjqOUoycS26pw1r22AF1lq7R21PdQ07fFyizmnwxEIKOkJaiBKUYi274LySDEJLUm9fo9V_wPi051k8o0mM2MMyEqKo9KZNTKRmcOtSu6vxLEayOQakalDoGpY5BVf_qXHUZJ7CP-pxMBW_OQBejg8s6Gl8eHRNS1O5UJ04OalcfPGRVjIdowPpc01A2-X884Td4vbA9
CODEN JACIBY
CitedBy_id crossref_primary_10_1016_j_jaip_2021_03_059
crossref_primary_10_1164_rccm_200811_1756PR
crossref_primary_10_1371_journal_pone_0178096
crossref_primary_10_1007_s12560_011_9056_7
crossref_primary_10_1164_rccm_2309004
crossref_primary_10_3389_falgy_2022_835748
crossref_primary_10_3389_fimmu_2022_782936
crossref_primary_10_1371_journal_pone_0115271
crossref_primary_10_3390_ijms20030678
crossref_primary_10_1186_s40248_015_0030_3
crossref_primary_10_1002_iid3_376
crossref_primary_10_3345_kjp_2014_57_6_271
crossref_primary_10_1016_j_iac_2004_09_008
crossref_primary_10_1111_cea_13374
crossref_primary_10_1111_cea_13372
crossref_primary_10_1016_j_micinf_2008_07_037
crossref_primary_10_1016_j_anai_2020_03_018
crossref_primary_10_3390_v13050915
crossref_primary_10_1016_j_anai_2022_01_007
crossref_primary_10_1128_microbiolspec_AID_0006_2012
crossref_primary_10_1016_j_jaci_2006_12_648
crossref_primary_10_1016_j_jaci_2012_03_040
crossref_primary_10_1080_02770900701883790
crossref_primary_10_1016_j_jaci_2020_01_035
crossref_primary_10_1111_imm_13240
crossref_primary_10_2147_JEP_S255211
crossref_primary_10_3389_fimmu_2022_865973
crossref_primary_10_1016_j_jaci_2006_08_041
crossref_primary_10_1016_j_jaci_2006_11_003
crossref_primary_10_1016_j_jaci_2006_12_642
crossref_primary_10_1016_j_idc_2005_05_010
crossref_primary_10_4049_jimmunol_177_10_6859
crossref_primary_10_1016_j_vascn_2021_107106
crossref_primary_10_5812_compreped_94685
crossref_primary_10_1111_j_1399_3038_2010_01026_x
crossref_primary_10_1002_iid3_102
crossref_primary_10_1111_cea_12313
crossref_primary_10_1371_journal_pone_0032061
crossref_primary_10_1007_s11882_016_0661_2
crossref_primary_10_1016_j_anai_2022_06_017
crossref_primary_10_1016_j_anai_2022_03_029
crossref_primary_10_1165_rcmb_2019_0004OC
crossref_primary_10_1016_j_jaip_2019_11_009
crossref_primary_10_1097_01_inf_0000215226_69696_0c
crossref_primary_10_1164_rccm_201002_0147ED
crossref_primary_10_1007_s11882_014_0502_0
crossref_primary_10_1016_j_iac_2019_03_003
crossref_primary_10_1016_j_pupt_2014_10_005
crossref_primary_10_1016_j_jaip_2021_05_034
crossref_primary_10_1111_cea_12390
crossref_primary_10_1152_physiolgenomics_00122_2017
crossref_primary_10_1007_s11882_008_0084_9
crossref_primary_10_1111_j_1398_9995_2007_01341_x
crossref_primary_10_1016_j_celrep_2019_12_027
crossref_primary_10_1378_chest_13_1567
crossref_primary_10_1164_rccm_200212_1520OC
crossref_primary_10_3402_ecrj_v2_28517
crossref_primary_10_1371_journal_pone_0106501
crossref_primary_10_1186_s12931_018_0914_9
crossref_primary_10_1016_S1155_195X_09_39289_0
crossref_primary_10_1186_1743_422X_6_122
crossref_primary_10_1016_j_coviro_2012_03_008
crossref_primary_10_1016_j_jaci_2003_11_027
crossref_primary_10_1097_00130832_200502000_00008
crossref_primary_10_1093_infdis_jis507
crossref_primary_10_1016_j_jaci_2008_08_013
crossref_primary_10_1016_j_jaci_2020_03_037
crossref_primary_10_4049_jimmunol_1600663
crossref_primary_10_1016_j_jaip_2015_05_029
crossref_primary_10_1164_rccm_201310_1767OC
crossref_primary_10_1016_j_jaci_2016_04_010
crossref_primary_10_1371_journal_pone_0140986
crossref_primary_10_1128_CVI_00414_15
crossref_primary_10_1016_j_iac_2014_09_012
crossref_primary_10_7581_pard_2011_21_2_78
crossref_primary_10_1097_01_inf_0000188164_33856_f9
crossref_primary_10_1097_01_mcp_0000146781_11092_0d
crossref_primary_10_21518_2079_701X_2020_17_19_24
crossref_primary_10_1002_eji_201445419
crossref_primary_10_1111_j_1365_2222_2011_03944_x
crossref_primary_10_1002_rmv_2193
crossref_primary_10_1016_j_imbio_2007_03_008
crossref_primary_10_3389_fmicb_2014_00226
crossref_primary_10_1016_j_rmed_2016_04_002
crossref_primary_10_1016_S1081_1206_10_61240_9
crossref_primary_10_1002_eji_201948396
crossref_primary_10_1016_j_jviromet_2014_10_021
crossref_primary_10_1016_j_jaci_2004_04_006
crossref_primary_10_3390_jpm11121374
crossref_primary_10_1016_S0761_8425_06_77730_0
Cites_doi 10.1164/ajrccm.159.3.9801052
10.1001/archinte.1958.00260140099015
10.1111/j.1365-2222.1994.tb00934.x
10.1136/bmj.307.6910.982
10.1016/0091-6749(88)90221-7
10.1164/ajrccm.160.4.9810083
10.1172/JCI113843
10.1016/0092-8674(89)90689-2
10.1136/thorax.57.4.328
10.1056/NEJM199110103251504
10.1093/infdis/142.6.811
10.1164/ajrccm.160.1.9808074
10.3109/00016488409128537
10.1093/infdis/169.5.1007
10.1067/mai.2000.106214
10.1542/peds.92.4.535
10.1067/mai.2000.108604
10.1016/S0022-3476(97)70204-X
10.1159/000236951
10.1164/ajrccm.159.3.9805103
10.1093/biomet/73.1.13
10.1067/mai.2000.109057
10.1172/JCI117581
10.1016/S0091-6749(96)70193-8
10.1136/bmj.310.6989.1225
10.1016/0091-6749(92)90219-R
10.1111/j.1365-2222.1989.tb02408.x
10.4049/jimmunol.137.1.245
10.1067/mai.2000.106378
10.1056/NEJM198902023200502
ContentType Journal Article
Copyright 2003 Mosby, Inc. All rights resered
2003 INIST-CNRS
Copyright Elsevier Limited May 2003
Copyright_xml – notice: 2003 Mosby, Inc. All rights resered
– notice: 2003 INIST-CNRS
– notice: Copyright Elsevier Limited May 2003
DBID IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7SS
7T5
H94
K9.
NAPCQ
7U9
7X8
DOI 10.1067/mai.2003.1396
DatabaseName Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Entomology Abstracts (Full archive)
Immunology Abstracts
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Premium
Virology and AIDS Abstracts
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Entomology Abstracts
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Premium
Immunology Abstracts
Virology and AIDS Abstracts
MEDLINE - Academic
DatabaseTitleList
Entomology Abstracts
MEDLINE
MEDLINE - Academic
AIDS and Cancer Research Abstracts
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1097-6825
EndPage 1016
ExternalDocumentID 3239587421
10_1067_mai_2003_1396
12743565
14797897
S0091674903801288
Genre Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S
Journal Article
GrantInformation_xml – fundername: NIAID NIH HHS
  grantid: 1P01 AI50989
– fundername: NCRR NIH HHS
  grantid: M01 RR00847
– fundername: NIAID NIH HHS
  grantid: AI20565
GroupedDBID ---
--K
--M
-~X
.1-
.55
.FO
.GJ
.XZ
.~1
0R~
1B1
1P~
1RT
1~.
1~5
354
3O-
3V.
4.4
457
4G.
53G
5GY
5RE
5VS
7-5
71M
7RV
7X7
8C1
8F7
8FE
8FH
8P~
9JM
AAAJQ
AABNK
AACTN
AAEDT
AAEDW
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AARKO
AAXUO
ABBQC
ABFNM
ABJNI
ABLJU
ABLVK
ABMAC
ABMZM
ABOCM
ABXDB
ABYKQ
ACDAQ
ACGFO
ACGFS
ACPRK
ACRLP
ADBBV
ADEZE
ADFRT
ADMUD
AEBSH
AEKER
AENEX
AFFNX
AFKRA
AFKWA
AFRAH
AFRHN
AFTJW
AFXIZ
AGEKW
AGHFR
AGUBO
AGYEJ
AHHHB
AHMBA
AHPSJ
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
AJRQY
AJUYK
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ANZVX
ASPBG
AVWKF
AXJTR
AZFZN
BBNVY
BENPR
BHPHI
BKOJK
BLXMC
BNPGV
BPHCQ
BVXVI
C45
CAG
CJTIS
COF
CS3
DU5
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
EX3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
HCIFZ
HDU
HMK
HMO
HVGLF
HZ~
IHE
J1W
J5H
K-O
KOM
L7B
LCYCR
LK8
LUGTX
M27
M2O
M41
M7P
MO0
N4W
N9A
O-L
O9-
O9~
OAUVE
OBH
ODZKP
OHH
OHT
OK0
OK1
OVD
OZT
P-8
P-9
P2P
PC.
PQQKQ
PROAC
Q38
R2-
RIG
ROL
RPZ
SAE
SCC
SDF
SDG
SDP
SEL
SES
SEW
SJN
SPCBC
SSH
SSI
SSZ
T5K
TEORI
TWZ
UGJ
UNMZH
UV1
WH7
WOW
WUQ
X7M
XFW
YOC
YQI
YQJ
Z5R
ZA5
ZGI
ZXP
ZY1
~02
~G-
~KM
08R
AAUGY
ABPIF
IQODW
AAXKI
ADVLN
AFJKZ
AKRWK
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
ACRPL
ADNMO
CITATION
7SS
7T5
H94
K9.
NAPCQ
7U9
7X8
ID FETCH-LOGICAL-c465t-f1b73a2c1ab06fce8977b904386a165ae35dcd4e23bb97b6696d3f0a950fe3fd3
IEDL.DBID AIKHN
ISSN 0091-6749
IngestDate Fri Oct 25 11:32:07 EDT 2024
Fri Oct 25 09:14:53 EDT 2024
Thu Oct 10 18:01:40 EDT 2024
Fri Dec 06 00:39:53 EST 2024
Sat Sep 28 08:34:50 EDT 2024
Sun Oct 22 16:02:14 EDT 2023
Fri Feb 23 02:23:42 EST 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 5
Keywords viral infections
allergic inflammation
eosinophil cationic protein
IgE
intracellular adhesion molecule-1
eosinophils
expired nitric oxide
rhinovirus
Asthma
Immunopathology
Allergy
Intercellular adhesion molecule 1
Respiratory disease
Picornaviridae
Granulocyte
Inflammation
Eosinophil
Virus
Infection
Nitric oxide
Obstructive pulmonary disease
Eosinophil cationic protein
Rhinovirus
Language English
License CC BY 4.0
https://www.elsevier.com/tdm/userlicense/1.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c465t-f1b73a2c1ab06fce8977b904386a165ae35dcd4e23bb97b6696d3f0a950fe3fd3
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
OpenAccessLink https://doi.org/10.1067/mai.2003.1396
PMID 12743565
PQID 1504840477
PQPubID 105664
PageCount 9
ParticipantIDs proquest_miscellaneous_73300728
proquest_miscellaneous_18779104
proquest_journals_1504840477
crossref_primary_10_1067_mai_2003_1396
pubmed_primary_12743565
pascalfrancis_primary_14797897
elsevier_sciencedirect_doi_10_1067_mai_2003_1396
PublicationCentury 2000
PublicationDate 2003-05-01
PublicationDateYYYYMMDD 2003-05-01
PublicationDate_xml – month: 05
  year: 2003
  text: 2003-05-01
  day: 01
PublicationDecade 2000
PublicationPlace New York, NY
PublicationPlace_xml – name: New York, NY
– name: United States
– name: St. Louis
PublicationTitle Journal of allergy and clinical immunology
PublicationTitleAlternate J Allergy Clin Immunol
PublicationYear 2003
Publisher Mosby, Inc
Elsevier
Elsevier Limited
Publisher_xml – name: Mosby, Inc
– name: Elsevier
– name: Elsevier Limited
References Riccio, Proud (bib23) 1996; 97
Staunton, Merlizzi, Rothlein, Barton, Marlin, Springer (bib34) 1989; 56
Sears, Burrows, Flannery, Herbison, Hewitt, Holdaway (bib7) 1991; 325
Bardin, Fraenkel, Sanderson, Dorward, Lau, Johnston (bib9) 1994; 24
Leigh, Belda, Kelly, Cox, Squillace, Gleich (bib36) 2000; 106
Hocking (bib24) 1996
Gern, Busse (bib13) 2000; 106
Sears, Herbison, Holdaway, Hewitt, Flannery, Silva (bib5) 1989; 19
Doyle, Skoner, Fireman, Seroky, Green, Ruben (bib8) 1992; 89
Grunberg, Timmers, de Klerk, Dick, Sterk (bib29) 1999; 160
Duff, Pomeranz, Gelber, Price, Hayden, Platts-Mills (bib37) 1993; 92
Cameron, Trivedi (bib28) 1998
Nelson, Sears, Woods, Ling, Hunt, Clapper (bib21) 1997; 130
Nicholson, Kent, Ireland (bib2) 1993; 307
Flemming, Little, Schnurr, Avila, Wong, Lui (bib14) 1999; 160
Halperin, Eggleston, Beasley, Surrat, Hendley, Groschel (bib11) 1985; 132
Papadopoulas, Stancin, Papi, Holgate, Johnston (bib32) 2000; 57
Burrows, Martinez, Halonen, Barbee, Cline (bib6) 1989; 320
Littell, Milliken, Stroup, Wolfinger (bib26) 1996
Proud, Gwaltney, Hendley, Dinarello, Gillis, Schleimer (bib10) 1994; 169
Winther, Farr, Turner, Hendley, Gwaltney, Mygind (bib35) 1984; 413
Calhoun, Dick, Schwartz, Busse (bib15) 1994; 94
Avila, Abisheganaden, Wong, Lin, Yagi, Schnurr (bib16) 2000; 105
Crater, Peters, Martin, Murphy, Platts-Mills (bib22) 1999; 159
Lemanske, Dick, Swenson, Vrtis, Busse (bib12) 1989; 83
SAS/STAT Software (bib25) 1997
Jackson, Dowling, Spiessman, Board (bib20) 1958; 101
Zimmerman, Feanny, Reisman, Hak, Rashed, McLaughlin (bib4) 1988; 81
Dustin, Rothlein, Bhan, Dinarello, Springer (bib31) 1986; 137
Gwaltney, Moskalski, Hendley (bib19) 1980; 142
Spector (bib18) 1983; Vol 1
Liang, Zeger (bib27) 1986; 73
Bardin, Fraenkel, Sanderson, Lampe, Holgate (bib30) 1995; 107
Rakes, Arruda, Ingram, Hoover, Zambrano, Hayden (bib3) 1999; 159
Guidelines for the Diagnosis and Management of Asthma (bib17) May 1997
Busse, Gern (bib33) 2000; 105
Johnston, Pattermore, Sanderson, Smith, Lampke, Josephs (bib1) 1995; 310
Avila (10.1067/mai.2003.1396_bib16) 2000; 105
Lemanske (10.1067/mai.2003.1396_bib12) 1989; 83
Gern (10.1067/mai.2003.1396_bib13) 2000; 106
Winther (10.1067/mai.2003.1396_bib35) 1984; 413
Flemming (10.1067/mai.2003.1396_bib14) 1999; 160
Riccio (10.1067/mai.2003.1396_bib23) 1996; 97
Bardin (10.1067/mai.2003.1396_bib30) 1995; 107
Johnston (10.1067/mai.2003.1396_bib1) 1995; 310
Guidelines for the Diagnosis and Management of Asthma (10.1067/mai.2003.1396_bib17) 1997
Littell (10.1067/mai.2003.1396_bib26) 1996
Busse (10.1067/mai.2003.1396_bib33) 2000; 105
Jackson (10.1067/mai.2003.1396_bib20) 1958; 101
Proud (10.1067/mai.2003.1396_bib10) 1994; 169
Rakes (10.1067/mai.2003.1396_bib3) 1999; 159
Halperin (10.1067/mai.2003.1396_bib11) 1985; 132
SAS/STAT Software (10.1067/mai.2003.1396_bib25) 1997
Papadopoulas (10.1067/mai.2003.1396_bib32) 2000; 57
Nelson (10.1067/mai.2003.1396_bib21) 1997; 130
Cameron (10.1067/mai.2003.1396_bib28) 1998
Dustin (10.1067/mai.2003.1396_bib31) 1986; 137
Liang (10.1067/mai.2003.1396_bib27) 1986; 73
Doyle (10.1067/mai.2003.1396_bib8) 1992; 89
Crater (10.1067/mai.2003.1396_bib22) 1999; 159
Gwaltney (10.1067/mai.2003.1396_bib19) 1980; 142
Calhoun (10.1067/mai.2003.1396_bib15) 1994; 94
Hocking (10.1067/mai.2003.1396_bib24) 1996
Staunton (10.1067/mai.2003.1396_bib34) 1989; 56
Zimmerman (10.1067/mai.2003.1396_bib4) 1988; 81
Spector (10.1067/mai.2003.1396_bib18) 1983; Vol 1
Sears (10.1067/mai.2003.1396_bib5) 1989; 19
Sears (10.1067/mai.2003.1396_bib7) 1991; 325
Leigh (10.1067/mai.2003.1396_bib36) 2000; 106
Grunberg (10.1067/mai.2003.1396_bib29) 1999; 160
Duff (10.1067/mai.2003.1396_bib37) 1993; 92
Nicholson (10.1067/mai.2003.1396_bib2) 1993; 307
Bardin (10.1067/mai.2003.1396_bib9) 1994; 24
Burrows (10.1067/mai.2003.1396_bib6) 1989; 320
References_xml – volume: 142
  start-page: 811
  year: 1980
  end-page: 815
  ident: bib19
  article-title: Interruption of experimental rhinovirus transmission
  publication-title: J Infect Dis
  contributor:
    fullname: Hendley
– volume: 19
  start-page: 419
  year: 1989
  end-page: 424
  ident: bib5
  article-title: The risks of sensitivity of grass pollen, house dust mite, and cat dander in the development of childhood asthma
  publication-title: Clin Exp Allergy
  contributor:
    fullname: Silva
– volume: 92
  start-page: 535
  year: 1993
  end-page: 540
  ident: bib37
  article-title: Risk factors for acute wheezing in infants and children: viruses, passive smoke, and IgE antibodies to inhalant allergens
  publication-title: Pediatrics
  contributor:
    fullname: Platts-Mills
– volume: 105
  start-page: 923
  year: 2000
  end-page: 932
  ident: bib16
  article-title: Effects of allergic inflammation of the nasal mucosa of the severity of rhinovirus 16 cold
  publication-title: J Allergy Clin Immunol
  contributor:
    fullname: Schnurr
– volume: 83
  start-page: 1
  year: 1989
  end-page: 10
  ident: bib12
  article-title: Rhinovirus upper respiratory tract infection increases airway hyperreactivity and late asthmatic reactions
  publication-title: J Clin Invest
  contributor:
    fullname: Busse
– volume: 101
  start-page: 267
  year: 1958
  end-page: 278
  ident: bib20
  article-title: Transmission of the common cold to volunteers under controlled conditions
  publication-title: Arch Int Med
  contributor:
    fullname: Board
– year: May 1997
  ident: bib17
  publication-title: NIH Publication No. 97-4051A,
  contributor:
    fullname: Guidelines for the Diagnosis and Management of Asthma
– year: 1997
  ident: bib25
  article-title: Changes and enhancements through Release 6.12
  contributor:
    fullname: SAS/STAT Software
– volume: 320
  start-page: 271
  year: 1989
  end-page: 277
  ident: bib6
  article-title: Association of asthma with serum IgE levels and skin-test reactivity to allergens
  publication-title: N Engl J Med
  contributor:
    fullname: Cline
– volume: 160
  start-page: 100
  year: 1999
  end-page: 108
  ident: bib14
  article-title: Rhinovirus-16 colds in healthy and in asthmatic subjects: similar changes in upper and lower airways
  publication-title: Am J Resp Crit Care Med
  contributor:
    fullname: Lui
– volume: 137
  start-page: 245
  year: 1986
  end-page: 254
  ident: bib31
  article-title: Induction by IL-1 and IFN-γ tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1)
  publication-title: J Immunol
  contributor:
    fullname: Springer
– volume: 106
  start-page: 201
  year: 2000
  end-page: 212
  ident: bib13
  article-title: The role of viral infections in the natural history of asthma
  publication-title: J Allergy Clin Immunol
  contributor:
    fullname: Busse
– volume: 310
  start-page: 1225
  year: 1995
  end-page: 1228
  ident: bib1
  article-title: Community study of role of viral infections in exacerbations of asthma in 9 to 11 year old children
  publication-title: BMJ
  contributor:
    fullname: Josephs
– volume: 81
  start-page: 63
  year: 1988
  end-page: 70
  ident: bib4
  article-title: The dose relationship of allergy to severity of childhood asthma
  publication-title: J Allergy Clin Immunol
  contributor:
    fullname: McLaughlin
– volume: 89
  start-page: 968
  year: 1992
  end-page: 978
  ident: bib8
  article-title: Rhinovirus 39 infection in allergic and nonallergic subjects
  publication-title: J Allergy Clin Immunol
  contributor:
    fullname: Ruben
– volume: 106
  start-page: 593
  year: 2000
  end-page: 594
  ident: bib36
  article-title: Eosinophil cationic protein relates to sputum neutrophil counts in healthy subjects
  publication-title: J Allergy Clin Immunol
  contributor:
    fullname: Gleich
– volume: 105
  start-page: 889
  year: 2000
  end-page: 891
  ident: bib33
  article-title: Do allergies protect against the effects of a rhinovirus cold?
  publication-title: J Allergy Clin Immunol
  contributor:
    fullname: Gern
– volume: 160
  start-page: 1375
  year: 1999
  end-page: 1380
  ident: bib29
  article-title: Experimental rhinovirus 16 infection causes variable airway obstruction in subjects with atopic asthma
  publication-title: Am J Resp Crit Care Med
  contributor:
    fullname: Sterk
– volume: 56
  start-page: 849
  year: 1989
  end-page: 853
  ident: bib34
  article-title: A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses
  publication-title: Cell
  contributor:
    fullname: Springer
– volume: 97
  start-page: 1252
  year: 1996
  end-page: 1263
  ident: bib23
  article-title: Evidence that enhanced nasal reactivity to bradykinin in patients with symptomatic allergy is mediated by normal reflexes
  publication-title: J Allergy Clin Immunol
  contributor:
    fullname: Proud
– volume: 132
  start-page: 976
  year: 1985
  end-page: 980
  ident: bib11
  article-title: Exacerbations of asthma in adults during experimental rhinovirus infection
  publication-title: Am Rev Respir Dis
  contributor:
    fullname: Groschel
– volume: 169
  start-page: 1007
  year: 1994
  ident: bib10
  article-title: Increased levels of interleukin-1 are detected in nasal secretions of volunteers during experimental rhinovirus colds
  publication-title: J Infect Dis
  contributor:
    fullname: Schleimer
– year: 1996
  ident: bib24
  article-title: Methods and applications of linear models
  contributor:
    fullname: Hocking
– volume: 73
  start-page: 13
  year: 1986
  end-page: 22
  ident: bib27
  article-title: Longitudinal data analysis using generalized linear models
  publication-title: Biometrika
  contributor:
    fullname: Zeger
– volume: 159
  start-page: 785
  year: 1999
  end-page: 790
  ident: bib3
  article-title: Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care
  publication-title: Am J Resp Crit Care Med
  contributor:
    fullname: Hayden
– volume: 94
  start-page: 2220
  year: 1994
  end-page: 2228
  ident: bib15
  article-title: A common cold virus, rhinovirus 16, potentiates airway inflammation after segmental antigen bronchoprovocation in allergic subjects
  publication-title: J Clin Invest
  contributor:
    fullname: Busse
– year: 1998
  ident: bib28
  article-title: Regression analysis of count data
  contributor:
    fullname: Trivedi
– volume: 325
  start-page: 1067
  year: 1991
  end-page: 1071
  ident: bib7
  article-title: Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children
  publication-title: N Engl J Med
  contributor:
    fullname: Holdaway
– volume: Vol 1
  start-page: 137
  year: 1983
  end-page: 176
  ident: bib18
  article-title: Bronchial inhalation challenges with aerosolized bronchoconstrictive substances
  publication-title: Provocative challegen procedures: bronchial, oral, nasal, and exercise
  contributor:
    fullname: Spector
– volume: 307
  start-page: 982
  year: 1993
  end-page: 986
  ident: bib2
  article-title: Respiratory viruses and exacerbations of asthma in adults
  publication-title: Br Med J
  contributor:
    fullname: Ireland
– volume: 159
  start-page: 806
  year: 1999
  end-page: 811
  ident: bib22
  article-title: Expired nitric oxide and airway obstruction in asthma patients with an acute exacerbation
  publication-title: Am J Respir Crit Care Med
  contributor:
    fullname: Platts-Mills
– volume: 24
  start-page: 457
  year: 1994
  end-page: 464
  ident: bib9
  article-title: Amplified rhinovirus colds in atopic subjects
  publication-title: Clin Exp Allergy
  contributor:
    fullname: Johnston
– year: 1996
  ident: bib26
  article-title: SAS systems for mixed models
  contributor:
    fullname: Wolfinger
– volume: 107
  start-page: 127
  year: 1995
  end-page: 129
  ident: bib30
  article-title: Lower airways inflammatory response during rhinovirus colds
  publication-title: Int Arch Allergy Immunol
  contributor:
    fullname: Holgate
– volume: 57
  start-page: 328
  year: 2000
  end-page: 332
  ident: bib32
  article-title: A defective type 1 response to rhinovirus in atopic asthma
  publication-title: Thorax
  contributor:
    fullname: Johnston
– volume: 130
  start-page: 423
  year: 1997
  end-page: 427
  ident: bib21
  article-title: Expired nitric oxide as a marker for childhood asthma
  publication-title: J Pediatr
  contributor:
    fullname: Clapper
– volume: 413
  start-page: 19
  year: 1984
  end-page: 24
  ident: bib35
  article-title: Histopatholgic examination and enumeration of polymorphonuclear leukocytes in the nasal mucosa during experimental rhinovirus colds
  publication-title: Acta Otolaryngol (Stockh)
  contributor:
    fullname: Mygind
– volume: 159
  start-page: 785
  year: 1999
  ident: 10.1067/mai.2003.1396_bib3
  article-title: Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care
  publication-title: Am J Resp Crit Care Med
  doi: 10.1164/ajrccm.159.3.9801052
  contributor:
    fullname: Rakes
– volume: 101
  start-page: 267
  year: 1958
  ident: 10.1067/mai.2003.1396_bib20
  article-title: Transmission of the common cold to volunteers under controlled conditions
  publication-title: Arch Int Med
  doi: 10.1001/archinte.1958.00260140099015
  contributor:
    fullname: Jackson
– year: 1996
  ident: 10.1067/mai.2003.1396_bib24
  contributor:
    fullname: Hocking
– year: 1998
  ident: 10.1067/mai.2003.1396_bib28
  contributor:
    fullname: Cameron
– volume: 24
  start-page: 457
  year: 1994
  ident: 10.1067/mai.2003.1396_bib9
  article-title: Amplified rhinovirus colds in atopic subjects
  publication-title: Clin Exp Allergy
  doi: 10.1111/j.1365-2222.1994.tb00934.x
  contributor:
    fullname: Bardin
– volume: 307
  start-page: 982
  year: 1993
  ident: 10.1067/mai.2003.1396_bib2
  article-title: Respiratory viruses and exacerbations of asthma in adults
  publication-title: Br Med J
  doi: 10.1136/bmj.307.6910.982
  contributor:
    fullname: Nicholson
– volume: 81
  start-page: 63
  year: 1988
  ident: 10.1067/mai.2003.1396_bib4
  article-title: The dose relationship of allergy to severity of childhood asthma
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/0091-6749(88)90221-7
  contributor:
    fullname: Zimmerman
– volume: 160
  start-page: 1375
  year: 1999
  ident: 10.1067/mai.2003.1396_bib29
  article-title: Experimental rhinovirus 16 infection causes variable airway obstruction in subjects with atopic asthma
  publication-title: Am J Resp Crit Care Med
  doi: 10.1164/ajrccm.160.4.9810083
  contributor:
    fullname: Grunberg
– volume: 83
  start-page: 1
  year: 1989
  ident: 10.1067/mai.2003.1396_bib12
  article-title: Rhinovirus upper respiratory tract infection increases airway hyperreactivity and late asthmatic reactions
  publication-title: J Clin Invest
  doi: 10.1172/JCI113843
  contributor:
    fullname: Lemanske
– volume: 56
  start-page: 849
  year: 1989
  ident: 10.1067/mai.2003.1396_bib34
  article-title: A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses
  publication-title: Cell
  doi: 10.1016/0092-8674(89)90689-2
  contributor:
    fullname: Staunton
– volume: 57
  start-page: 328
  year: 2000
  ident: 10.1067/mai.2003.1396_bib32
  article-title: A defective type 1 response to rhinovirus in atopic asthma
  publication-title: Thorax
  doi: 10.1136/thorax.57.4.328
  contributor:
    fullname: Papadopoulas
– year: 1996
  ident: 10.1067/mai.2003.1396_bib26
  contributor:
    fullname: Littell
– volume: 325
  start-page: 1067
  year: 1991
  ident: 10.1067/mai.2003.1396_bib7
  article-title: Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199110103251504
  contributor:
    fullname: Sears
– year: 1997
  ident: 10.1067/mai.2003.1396_bib17
  contributor:
    fullname: Guidelines for the Diagnosis and Management of Asthma
– volume: 142
  start-page: 811
  year: 1980
  ident: 10.1067/mai.2003.1396_bib19
  article-title: Interruption of experimental rhinovirus transmission
  publication-title: J Infect Dis
  doi: 10.1093/infdis/142.6.811
  contributor:
    fullname: Gwaltney
– volume: Vol 1
  start-page: 137
  year: 1983
  ident: 10.1067/mai.2003.1396_bib18
  article-title: Bronchial inhalation challenges with aerosolized bronchoconstrictive substances
  contributor:
    fullname: Spector
– volume: 160
  start-page: 100
  year: 1999
  ident: 10.1067/mai.2003.1396_bib14
  article-title: Rhinovirus-16 colds in healthy and in asthmatic subjects: similar changes in upper and lower airways
  publication-title: Am J Resp Crit Care Med
  doi: 10.1164/ajrccm.160.1.9808074
  contributor:
    fullname: Flemming
– volume: 413
  start-page: 19
  year: 1984
  ident: 10.1067/mai.2003.1396_bib35
  article-title: Histopatholgic examination and enumeration of polymorphonuclear leukocytes in the nasal mucosa during experimental rhinovirus colds
  publication-title: Acta Otolaryngol (Stockh)
  doi: 10.3109/00016488409128537
  contributor:
    fullname: Winther
– volume: 132
  start-page: 976
  year: 1985
  ident: 10.1067/mai.2003.1396_bib11
  article-title: Exacerbations of asthma in adults during experimental rhinovirus infection
  publication-title: Am Rev Respir Dis
  contributor:
    fullname: Halperin
– volume: 169
  start-page: 1007
  year: 1994
  ident: 10.1067/mai.2003.1396_bib10
  article-title: Increased levels of interleukin-1 are detected in nasal secretions of volunteers during experimental rhinovirus colds
  publication-title: J Infect Dis
  doi: 10.1093/infdis/169.5.1007
  contributor:
    fullname: Proud
– volume: 105
  start-page: 923
  year: 2000
  ident: 10.1067/mai.2003.1396_bib16
  article-title: Effects of allergic inflammation of the nasal mucosa of the severity of rhinovirus 16 cold
  publication-title: J Allergy Clin Immunol
  doi: 10.1067/mai.2000.106214
  contributor:
    fullname: Avila
– volume: 92
  start-page: 535
  year: 1993
  ident: 10.1067/mai.2003.1396_bib37
  article-title: Risk factors for acute wheezing in infants and children: viruses, passive smoke, and IgE antibodies to inhalant allergens
  publication-title: Pediatrics
  doi: 10.1542/peds.92.4.535
  contributor:
    fullname: Duff
– volume: 106
  start-page: 201
  year: 2000
  ident: 10.1067/mai.2003.1396_bib13
  article-title: The role of viral infections in the natural history of asthma
  publication-title: J Allergy Clin Immunol
  doi: 10.1067/mai.2000.108604
  contributor:
    fullname: Gern
– volume: 130
  start-page: 423
  year: 1997
  ident: 10.1067/mai.2003.1396_bib21
  article-title: Expired nitric oxide as a marker for childhood asthma
  publication-title: J Pediatr
  doi: 10.1016/S0022-3476(97)70204-X
  contributor:
    fullname: Nelson
– volume: 107
  start-page: 127
  year: 1995
  ident: 10.1067/mai.2003.1396_bib30
  article-title: Lower airways inflammatory response during rhinovirus colds
  publication-title: Int Arch Allergy Immunol
  doi: 10.1159/000236951
  contributor:
    fullname: Bardin
– volume: 159
  start-page: 806
  year: 1999
  ident: 10.1067/mai.2003.1396_bib22
  article-title: Expired nitric oxide and airway obstruction in asthma patients with an acute exacerbation
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/ajrccm.159.3.9805103
  contributor:
    fullname: Crater
– volume: 73
  start-page: 13
  year: 1986
  ident: 10.1067/mai.2003.1396_bib27
  article-title: Longitudinal data analysis using generalized linear models
  publication-title: Biometrika
  doi: 10.1093/biomet/73.1.13
  contributor:
    fullname: Liang
– volume: 106
  start-page: 593
  year: 2000
  ident: 10.1067/mai.2003.1396_bib36
  article-title: Eosinophil cationic protein relates to sputum neutrophil counts in healthy subjects
  publication-title: J Allergy Clin Immunol
  doi: 10.1067/mai.2000.109057
  contributor:
    fullname: Leigh
– volume: 94
  start-page: 2220
  year: 1994
  ident: 10.1067/mai.2003.1396_bib15
  article-title: A common cold virus, rhinovirus 16, potentiates airway inflammation after segmental antigen bronchoprovocation in allergic subjects
  publication-title: J Clin Invest
  doi: 10.1172/JCI117581
  contributor:
    fullname: Calhoun
– year: 1997
  ident: 10.1067/mai.2003.1396_bib25
  contributor:
    fullname: SAS/STAT Software
– volume: 97
  start-page: 1252
  year: 1996
  ident: 10.1067/mai.2003.1396_bib23
  article-title: Evidence that enhanced nasal reactivity to bradykinin in patients with symptomatic allergy is mediated by normal reflexes
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/S0091-6749(96)70193-8
  contributor:
    fullname: Riccio
– volume: 310
  start-page: 1225
  year: 1995
  ident: 10.1067/mai.2003.1396_bib1
  article-title: Community study of role of viral infections in exacerbations of asthma in 9 to 11 year old children
  publication-title: BMJ
  doi: 10.1136/bmj.310.6989.1225
  contributor:
    fullname: Johnston
– volume: 89
  start-page: 968
  year: 1992
  ident: 10.1067/mai.2003.1396_bib8
  article-title: Rhinovirus 39 infection in allergic and nonallergic subjects
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/0091-6749(92)90219-R
  contributor:
    fullname: Doyle
– volume: 19
  start-page: 419
  year: 1989
  ident: 10.1067/mai.2003.1396_bib5
  article-title: The risks of sensitivity of grass pollen, house dust mite, and cat dander in the development of childhood asthma
  publication-title: Clin Exp Allergy
  doi: 10.1111/j.1365-2222.1989.tb02408.x
  contributor:
    fullname: Sears
– volume: 137
  start-page: 245
  year: 1986
  ident: 10.1067/mai.2003.1396_bib31
  article-title: Induction by IL-1 and IFN-γ tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1)
  publication-title: J Immunol
  doi: 10.4049/jimmunol.137.1.245
  contributor:
    fullname: Dustin
– volume: 105
  start-page: 889
  year: 2000
  ident: 10.1067/mai.2003.1396_bib33
  article-title: Do allergies protect against the effects of a rhinovirus cold?
  publication-title: J Allergy Clin Immunol
  doi: 10.1067/mai.2000.106378
  contributor:
    fullname: Busse
– volume: 320
  start-page: 271
  year: 1989
  ident: 10.1067/mai.2003.1396_bib6
  article-title: Association of asthma with serum IgE levels and skin-test reactivity to allergens
  publication-title: N Engl J Med
  doi: 10.1056/NEJM198902023200502
  contributor:
    fullname: Burrows
SSID ssj0009389
Score 2.1496875
Snippet Although most children and young adults with asthma are atopic, exacerbations of asthma are frequently associated with viral respiratory tract infections,...
Background: Although most children and young adults with asthma are atopic, exacerbations of asthma are frequently associated with viral respiratory tract...
BACKGROUNDAlthough most children and young adults with asthma are atopic, exacerbations of asthma are frequently associated with viral respiratory tract...
SourceID proquest
crossref
pubmed
pascalfrancis
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 1008
SubjectTerms Adolescent
Adult
allergic inflammation
Asthma
Asthma - immunology
Biological and medical sciences
Blood Proteins - analysis
Chronic obstructive pulmonary disease, asthma
Common Cold
eosinophil cationic protein
Eosinophil Granule Proteins
eosinophils
expired nitric oxide
Female
Human viral diseases
Humans
IgE
Immunoglobulin E - blood
Infectious diseases
Intercellular Adhesion Molecule-1 - analysis
intracellular adhesion molecule-1
Lung - physiopathology
Male
Medical sciences
Nasal Mucosa - chemistry
Nitric Oxide - biosynthesis
Picornaviridae Infections - etiology
Picornaviridae Infections - immunology
Pneumology
Rhinovirus
Ribonucleases
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
viral infections
Title Experimental rhinovirus challenges in adults with mild asthma: Response to infection in relation to IgE
URI https://dx.doi.org/10.1067/mai.2003.1396
https://www.ncbi.nlm.nih.gov/pubmed/12743565
https://www.proquest.com/docview/1504840477
https://search.proquest.com/docview/18779104
https://search.proquest.com/docview/73300728
Volume 111
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB71ISEkhHizUBYfELd0k9ixY25VtdUW1B4QlXqL7NhuI7HZ1SbLkd_O2HFYetgD19gjJ2N7_E1m_A3ApxoxEFc5T2pjecKsKhOdpzIRnJc5K0SuAs_s1TVf3LCvt8XtAZyPd2F8WmW0_YNND9Y6PplFbc7WTePv-EqfQi9TGqxseQjHeBz5WO3x2eW3xfWOe5eWAwqWWeIFItUm2unZUjWBE_QUgRDfdzQ9WasOFeaGShf7oWg4ki6ewdOIJcnZ8LrP4cC2L-DRVYyWv4S7-T_0_WRz37SrX81m25F6rKDSkaYlgYKjI_6PLFk2Pw1RXX-_VF_I9yF_1pJ-RcakrdZLbGIGnW-4vJu_gpuL-Y_zRRILKyQ140WfuEwLqvI6UzrlrrYlgkAtfUyQq4wXytLC1IbZnGotheZcckNdqmSROkudoa_hqF219i2Qwip0GplTOq-ZFVKaMjeOUpty60yWTuDzqNNqPfBnVCHuzUWFyvdVMGnllT-BdNR49WABVGjb94lMH8zMbgAm0DmWYgIn41RVcWt2FSJghl4tE9j88W8zbiofKVGtXW2xTykE4ii2v4eg1JOulxN4MyyB3eDo51OEye_-_4Pew-OQKxjyKU_gqN9s7QfEPL2ewuHp72waV_YfSTwA_g
link.rule.ids 314,780,784,4502,24116,27924,27925,45585,45679
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3Pb9MwFLbGJgESQvwaFMbmA-IWmsSOHXObpk4tW3tAm7SbZcf2FommVZPy9_PsOJQdeuAa23Ly_Pz8vbzn7yH0pQIMxFTOkspYllCrykTnqUg4Y2VOC56rwDM7X7DpLf1xV9wdoIvhLoxPq4y2v7fpwVrHJ-MozfG6rv0dX-FT6EVKgpUtn6AjQAMcVPvofHY1Xey4d0nZo2CRJX5ApNoEOz1eqjpwgn4DIMT2HU0v1qoFgbm-0sV-KBqOpMtX6GXEkvi8f93X6MA2b9DTeYyWv0X3k3_o-_HmoW5Wv-vNtsXVUEGlxXWDAwVHi_0fWbysfxms2u5hqb7jn33-rMXdCg9JW40fsYkZdL5hdj95h24vJzcX0yQWVkgqyooucZnmROVVpnTKXGVLAIFa-JggUxkrlCWFqQy1OdFacM2YYIa4VIkidZY4Q47RYbNq7AeEC6vAaaRO6byilgthytw4QmzKrDNZOkJfB5nKdc-fIUPcm3EJwvdVMIn0wh-hdJC4fKQAEmz7viGnj1ZmNwHl4BwLPkInw1LJuDVbCQiYgldLOTSf_W2GTeUjJaqxqy30KTkHHEX39-CEeNL1coTe9yqwmxz8fAIw-eP_f9AZeja9mV_L69ni6hN6HvIGQ27lCTrsNlv7GfBPp0-jfv8BmdMC-w
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Experimental+rhinovirus+challenges+in+adults+with+mild+asthma%3A+Response+to+infection+in+relation+to+IgE&rft.jtitle=Journal+of+allergy+and+clinical+immunology&rft.au=Zambrano%2C+Juan+C&rft.au=Carper%2C+Holliday+T&rft.au=Rakes%2C+Gary+P&rft.au=Patrie%2C+James&rft.date=2003-05-01&rft.pub=Elsevier+Limited&rft.issn=0091-6749&rft.eissn=1097-6825&rft.volume=111&rft.issue=5&rft.spage=1008&rft_id=info:doi/10.1067%2Fmai.2003.1396&rft.externalDBID=NO_FULL_TEXT&rft.externalDocID=3239587421
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0091-6749&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0091-6749&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0091-6749&client=summon