Sensitivity and Specificity of Biochemical Tests for Diagnosis of Intrahepatic Cholestasis of Pregnancy
AbstractBackground and aimIntrahepatic cholestasis of pregnancy (ICP) is linked with increased risk of fetal complications. An accurate diagnostic test is needed to diagnose this disorder on time. We aimed to assess sensitivity and specificity of laboratory tests used for diagnosis of intrahepatic c...
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Published in | Annals of hepatology Vol. 16; no. 4; pp. 569 - 573 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Elsevier
01.07.2017
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Abstract | AbstractBackground and aimIntrahepatic cholestasis of pregnancy (ICP) is linked with increased risk of fetal complications. An accurate diagnostic test is needed to diagnose this disorder on time. We aimed to assess sensitivity and specificity of laboratory tests used for diagnosis of intrahepatic cholestasis of pregnancy and determine more reliable cut-off values of transaminases. Material and methodsSixty one symptomatic patients with ICP and 29 healthy pregnant women were included in the retrospective analysis. ResultsICP patients had higher total bile acids (TBA) levels than healthy women (32 vs. 6; P < 0.0001) due to increase in cholic acid (CA) and chenodeoxycholic acid (CDCA). CA/CDCA ratio was significantly higher in ICP patients compared to healthy pregnant women (1.13 vs. 0.68; P < 0.00002). TBA, CA, CDCA and CA/CDCA ratio demonstrate the following sensitivity (94%, 96%, 89%, 71.9%) and specificity (63%, 63%, 59%, 79.3%, respectively) for ICP diagnosis. Lowering cut-off values for ALT (31 U/ L) and AST (30 U/L) resulted only in minimal increase of sensitivity to 92.2% vs. 90.1% for ALT and to 92.2%, vs. 90.6% for AST. ConclusionThe present study did not reveal any single specific and sensitive marker for reliable diagnosis of ICP. Establishment of lower cut-off values for transaminases activity might only minimally increase the accuracy of diagnosing ICP. |
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AbstractList | Intrahepatic cholestasis of pregnancy (ICP) is linked with increased risk of fetal complications. An accurate diagnostic test is needed to diagnose this disorder on time. We aimed to assess sensitivity and specificity of laboratory tests used for diagnosis of intrahepatic cholestasis of pregnancy and determine more reliable cut-off values of transaminases.
Sixty one symptomatic patients with ICP and 29 healthy pregnant women were included in the retrospective analysis.
ICP patients had higher total bile acids (TBA) levels than healthy women (32 vs. 6; P < 0.0001) due to increase in cholic acid (CA) and chenodeoxycholic acid (CDCA). CA/CDCA ratio was significantly higher in ICP patients compared to healthy pregnant women (1.13 vs. 0.68; P < 0.00002). TBA, CA, CDCA and CA/CDCA ratio demonstrate the following sensitivity (94%, 96%, 89%, 71.9%) and specificity (63%, 63%, 59%, 79.3%, respectively) for ICP diagnosis. Lowering cut-off values for ALT (31 U/L) and AST (30 U/L) resulted only in minimal increase of sensitivity to 92.2% vs. 90.1% for ALT and to 92.2%, vs. 90.6% for AST.
The present study did not reveal any single specific and sensitive marker for reliable diagnosis of ICP. Establishment of lower cut-off values for transaminases activity might only minimally increase the accuracy of diagnosing ICP. Background and aim: Intrahepatic cholestasis of pregnancy (ICP) is linked with increased risk of fetal complications. An accurate diagnostic test is needed to diagnose this disorder on time. We aimed to assess sensitivity and specificity of laboratory tests used for diagnosis of intrahepatic cholestasis of pregnancy and determine more reliable cut-off values of transaminases. Material and methods: Sixty one symptomatic patients with ICP and 29 healthy pregnant women were included in the retrospective analysis. Results: ICP patients had higher total bile acids (TBA) levels than healthy women (32 vs. 6; P < 0.0001) due to increase in cholic acid (CA) and chenodeoxycholic acid (CDCA). CA/CDCA ratio was significantly higher in ICP patients compared to healthy pregnant women (1.13 vs. 0.68; P < 0.00002). TBA, CA, CDCA and CA/CDCA ratio demonstrate the following sensitivity (94%, 96%, 89%, 71.9%) and specificity (63%, 63%, 59%, 79.3%, respectively) for ICP diagnosis. Lowering cut-off values for ALT (31 U/ L) and AST (30 U/L) resulted only in minimal increase of sensitivity to 92.2% vs. 90.1% for ALT and to 92.2%, vs. 90.6% for AST. Conclusion: The present study did not reveal any single specific and sensitive marker for reliable diagnosis of ICP. Establishment of lower cut-off values for transaminases activity might only minimally increase the accuracy of diagnosing ICP. AbstractBackground and aimIntrahepatic cholestasis of pregnancy (ICP) is linked with increased risk of fetal complications. An accurate diagnostic test is needed to diagnose this disorder on time. We aimed to assess sensitivity and specificity of laboratory tests used for diagnosis of intrahepatic cholestasis of pregnancy and determine more reliable cut-off values of transaminases. Material and methodsSixty one symptomatic patients with ICP and 29 healthy pregnant women were included in the retrospective analysis. ResultsICP patients had higher total bile acids (TBA) levels than healthy women (32 vs. 6; P < 0.0001) due to increase in cholic acid (CA) and chenodeoxycholic acid (CDCA). CA/CDCA ratio was significantly higher in ICP patients compared to healthy pregnant women (1.13 vs. 0.68; P < 0.00002). TBA, CA, CDCA and CA/CDCA ratio demonstrate the following sensitivity (94%, 96%, 89%, 71.9%) and specificity (63%, 63%, 59%, 79.3%, respectively) for ICP diagnosis. Lowering cut-off values for ALT (31 U/ L) and AST (30 U/L) resulted only in minimal increase of sensitivity to 92.2% vs. 90.1% for ALT and to 92.2%, vs. 90.6% for AST. ConclusionThe present study did not reveal any single specific and sensitive marker for reliable diagnosis of ICP. Establishment of lower cut-off values for transaminases activity might only minimally increase the accuracy of diagnosing ICP. BACKGROUND AND AIMIntrahepatic cholestasis of pregnancy (ICP) is linked with increased risk of fetal complications. An accurate diagnostic test is needed to diagnose this disorder on time. We aimed to assess sensitivity and specificity of laboratory tests used for diagnosis of intrahepatic cholestasis of pregnancy and determine more reliable cut-off values of transaminases. MATERIAL AND METHODSSixty one symptomatic patients with ICP and 29 healthy pregnant women were included in the retrospective analysis. RESULTSICP patients had higher total bile acids (TBA) levels than healthy women (32 vs. 6; P < 0.0001) due to increase in cholic acid (CA) and chenodeoxycholic acid (CDCA). CA/CDCA ratio was significantly higher in ICP patients compared to healthy pregnant women (1.13 vs. 0.68; P < 0.00002). TBA, CA, CDCA and CA/CDCA ratio demonstrate the following sensitivity (94%, 96%, 89%, 71.9%) and specificity (63%, 63%, 59%, 79.3%, respectively) for ICP diagnosis. Lowering cut-off values for ALT (31 U/L) and AST (30 U/L) resulted only in minimal increase of sensitivity to 92.2% vs. 90.1% for ALT and to 92.2%, vs. 90.6% for AST. CONCLUSIONThe present study did not reveal any single specific and sensitive marker for reliable diagnosis of ICP. Establishment of lower cut-off values for transaminases activity might only minimally increase the accuracy of diagnosing ICP. |
Author | Vladas, Gintautas Limas, Kupcinskas Jurate, Kondrackiene Jolanta, Sumskiene Rimantas, Zalinkevicius |
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Cites_doi | 10.1053/j.gastro.2005.06.019 10.1371/journal.pone.0028343 10.3748/wjg.14.5781 10.1111/j.1478-3231.2006.01197.x 10.1016/j.ijgo.2013.02.015 10.1097/01.AOG.0000187951.98401.f7 10.1002/hep.21111 10.1016/S0022-2275(20)34446-1 10.1055/s-0028-1103158 10.1007/s00404-009-1052-x 10.1002/hep.26909 10.1016/j.jhep.2014.10.041 10.3748/wjg.v13.i46.6226 10.1067/S0002-9378(03)00545-3 10.1111/j.1471-0528.1997.tb11054.x 10.1002/hep.20336 10.1002/hep.26617 10.1016/j.ajog.2013.11.017 10.1016/S1089-3261(03)00131-4 10.1016/j.jhep.2007.08.015 10.1038/ajg.2013.406 10.1042/CS20050302 10.3748/wjg.15.2049 10.1002/hep.26444 10.1053/j.gastro.2010.05.009 10.7326/0003-4819-137-1-200207020-00006 |
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References | Huang (10.5604/01.3001.0010.0294_bib0075) 2009; 26 Beuers (10.5604/01.3001.0010.0294_bib0015) 2014; 60 Oztekin (10.5604/01.3001.0010.0294_bib0055) 2009; 280 Riely (10.5604/01.3001.0010.0294_bib0010) 2004; 8 Kondrackiene (10.5604/01.3001.0010.0294_bib0100) 2005; 129 Castano (10.5604/01.3001.0010.0294_bib0115) 2006; 110 Glantz (10.5604/01.3001.0010.0294_bib0040) 2004; 4 Kondrackiene (10.5604/01.3001.0010.0294_bib0020) 2008; 14 Sentilhes (10.5604/01.3001.0010.0294_bib0110) 2006; 107 Rook (10.5604/01.3001.0010.0294_bib0050) 2012; 7 Prati (10.5604/01.3001.0010.0294_bib0120) 2002; 137 Dixon (10.5604/01.3001.0010.0294_bib0025) 2014; 109 Kariv (10.5604/01.3001.0010.0294_bib0085) 2006; 26 Marschall (10.5604/01.3001.0010.0294_bib0135) 2013; 58 Silver (10.5604/01.3001.0010.0294_bib0065) 2014; 210 Stellaard (10.5604/01.3001.0010.0294_bib0105) 1984; 25 Kondrackiene (10.5604/01.3001.0010.0294_bib0060) 2007; 13 Girling (10.5604/01.3001.0010.0294_bib0125) 1997; 104 Ropponen (10.5604/01.3001.0010.0294_bib0130) 2006; 43 Geenes (10.5604/01.3001.0010.0294_bib0080) 2009; 15 Geenes (10.5604/01.3001.0010.0294_bib0045) 2014; 59 Kremer (10.5604/01.3001.0010.0294_bib0090) 2010; 139 Germain (10.5604/01.3001.0010.0294_bib0035) 2003; 189 Kremer (10.5604/01.3001.0010.0294_bib0095) 2015; 62 Chen (10.5604/01.3001.0010.0294_bib0070) 2013; 122 Sookoian (10.5604/01.3001.0010.0294_bib0030) 2008; 48 |
References_xml | – volume: 129 start-page: 894 year: 2005 ident: 10.5604/01.3001.0010.0294_bib0100 article-title: Efficacy and safety of ursodeoxycholic acid versus cholestyramine in intrahepatic cholestasis of pregnancy publication-title: Gastroenterology doi: 10.1053/j.gastro.2005.06.019 contributor: fullname: Kondrackiene – volume: 7 start-page: e28343 year: 2012 ident: 10.5604/01.3001.0010.0294_bib0050 article-title: Fetal outcomes in pregnancies complicated by intrahepatic cholestasis of pregnancy in a Northern California cohort publication-title: PLoS One doi: 10.1371/journal.pone.0028343 contributor: fullname: Rook – volume: 14 start-page: 5781 year: 2008 ident: 10.5604/01.3001.0010.0294_bib0020 article-title: Intrahepatic cholestasis of pregnancy-current achievements and unsolved problems publication-title: World J Gastroenterol doi: 10.3748/wjg.14.5781 contributor: fullname: Kondrackiene – volume: 26 start-page: 445 year: 2006 ident: 10.5604/01.3001.0010.0294_bib0085 article-title: Re-evaluation of serum alanine aminotrans-ferase upper normal limit and its modulating factors in a large-scale population study publication-title: Liver Int doi: 10.1111/j.1478-3231.2006.01197.x contributor: fullname: Kariv – volume: 122 start-page: 5 year: 2013 ident: 10.5604/01.3001.0010.0294_bib0070 article-title: Primary bile acids as potential biomarkers for the clinical grading of intra-hepatic cholestasis of pregnancy publication-title: Int J Gynaecol Obstet doi: 10.1016/j.ijgo.2013.02.015 contributor: fullname: Chen – volume: 107 start-page: 458 year: 2006 ident: 10.5604/01.3001.0010.0294_bib0110 article-title: Fetal death in a patient with intrahepatic cholestasis of pregnancy publication-title: Obstet Gynecol doi: 10.1097/01.AOG.0000187951.98401.f7 contributor: fullname: Sentilhes – volume: 43 start-page: 723 year: 2006 ident: 10.5604/01.3001.0010.0294_bib0130 article-title: Intrahepatic cholestasis of pregnancy as an indicator of liver and biliary diseases: a population-based study publication-title: Hepatology doi: 10.1002/hep.21111 contributor: fullname: Ropponen – volume: 25 start-page: 1313 year: 1984 ident: 10.5604/01.3001.0010.0294_bib0105 article-title: Simultaneous determination of cholic acid and chenodeoxycholic acid pool sizes and fractional turnover rates in human serum using 13C-labeled bile acids publication-title: J Lipid Res doi: 10.1016/S0022-2275(20)34446-1 contributor: fullname: Stellaard – volume: 26 start-page: 291 year: 2009 ident: 10.5604/01.3001.0010.0294_bib0075 article-title: Bile acid ratio in diagnosis of intrahepatic cholestasis of pregnancy publication-title: Am J Perinatol doi: 10.1055/s-0028-1103158 contributor: fullname: Huang – volume: 280 start-page: 975 year: 2009 ident: 10.5604/01.3001.0010.0294_bib0055 article-title: Predicting fetal asphyxia in intrahepatic cholestasis of pregnancy publication-title: Arch Gynecol Obstet doi: 10.1007/s00404-009-1052-x contributor: fullname: Oztekin – volume: 60 start-page: 399 year: 2014 ident: 10.5604/01.3001.0010.0294_bib0015 article-title: Pruritus in cholestasis: Facts and fiction publication-title: Hepatology doi: 10.1002/hep.26909 contributor: fullname: Beuers – volume: 62 start-page: 897 year: 2015 ident: 10.5604/01.3001.0010.0294_bib0095 article-title: Autotaxin Activity has a high Accuracy to diagnose Intrahepatic Cholestasis of Pregnancy publication-title: J Hepatol doi: 10.1016/j.jhep.2014.10.041 contributor: fullname: Kremer – volume: 13 start-page: 6226 year: 2007 ident: 10.5604/01.3001.0010.0294_bib0060 article-title: Predictors of premature delivery in patients with intrahepatic cholestasis of pregnancy publication-title: World J Gastroenterol doi: 10.3748/wjg.v13.i46.6226 contributor: fullname: Kondrackiene – volume: 189 start-page: 577 year: 2003 ident: 10.5604/01.3001.0010.0294_bib0035 article-title: Bile acids increase response and expression of human myometrial oxytocin receptor publication-title: Am J Obstet Gynecol doi: 10.1067/S0002-9378(03)00545-3 contributor: fullname: Germain – volume: 104 start-page: 246 year: 1997 ident: 10.5604/01.3001.0010.0294_bib0125 article-title: Liver function tests in pre-ec-lampsia: importance of comparison with a reference range derived for normal pregnancy publication-title: Br J Obstet Gynaecol doi: 10.1111/j.1471-0528.1997.tb11054.x contributor: fullname: Girling – volume: 4 start-page: 467 year: 2004 ident: 10.5604/01.3001.0010.0294_bib0040 article-title: Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates publication-title: Hepatology doi: 10.1002/hep.20336 contributor: fullname: Glantz – volume: 59 start-page: 1482 year: 2014 ident: 10.5604/01.3001.0010.0294_bib0045 article-title: Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population-based case-control study publication-title: Hepatology doi: 10.1002/hep.26617 contributor: fullname: Geenes – volume: 210 start-page: 460 year: 2014 ident: 10.5604/01.3001.0010.0294_bib0065 article-title: Bile acids in a multicenter, population-based case-control study of stillbirth publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2013.11.017 contributor: fullname: Silver – volume: 8 start-page: 167 year: 2004 ident: 10.5604/01.3001.0010.0294_bib0010 article-title: Intrahepatic cholestasis of pregnancy publication-title: Clin Liver Dis doi: 10.1016/S1089-3261(03)00131-4 contributor: fullname: Riely – volume: 48 start-page: 125 year: 2008 ident: 10.5604/01.3001.0010.0294_bib0030 article-title: Association of the multidrug-resistance-associated protein gene (ABCC2) variants with intrahepatic cholestasis of pregnancy publication-title: J Hepatol doi: 10.1016/j.jhep.2007.08.015 contributor: fullname: Sookoian – volume: 109 start-page: 76 year: 2014 ident: 10.5604/01.3001.0010.0294_bib0025 article-title: A comprehensive analysis of common genetic variation around six candidate loci for intrahepatic cholestasis of pregnancy publication-title: Am J Gastroenterol doi: 10.1038/ajg.2013.406 contributor: fullname: Dixon – volume: 110 start-page: 459 year: 2006 ident: 10.5604/01.3001.0010.0294_bib0115 article-title: Bile acid profiles by capillary electrophoresis in intrahepatic cholestasis of pregnancy publication-title: Clin Sci (Lond) doi: 10.1042/CS20050302 contributor: fullname: Castano – volume: 15 start-page: 2049 year: 2009 ident: 10.5604/01.3001.0010.0294_bib0080 article-title: Intrahepatic cholestasis of pregnancy publication-title: World J Gastroenterol doi: 10.3748/wjg.15.2049 contributor: fullname: Geenes – volume: 58 start-page: 1385 year: 2013 ident: 10.5604/01.3001.0010.0294_bib0135 article-title: Intrahepatic cholestasis of pregnancy and associated hepatobiliary disease: a population-based cohort study publication-title: Hepatology doi: 10.1002/hep.26444 contributor: fullname: Marschall – volume: 139 start-page: 1008 year: 2010 ident: 10.5604/01.3001.0010.0294_bib0090 article-title: Lysophosphatidic acid is a potential mediator of cholestatic pruritus publication-title: Gastroenterology doi: 10.1053/j.gastro.2010.05.009 contributor: fullname: Kremer – volume: 137 start-page: 1 year: 2002 ident: 10.5604/01.3001.0010.0294_bib0120 article-title: Updated definitions of healthy ranges for serum alanine aminotransferase levels publication-title: Ann Intern Med doi: 10.7326/0003-4819-137-1-200207020-00006 contributor: fullname: Prati |
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Snippet | AbstractBackground and aimIntrahepatic cholestasis of pregnancy (ICP) is linked with increased risk of fetal complications. An accurate diagnostic test is... Intrahepatic cholestasis of pregnancy (ICP) is linked with increased risk of fetal complications. An accurate diagnostic test is needed to diagnose this... BACKGROUND AND AIMIntrahepatic cholestasis of pregnancy (ICP) is linked with increased risk of fetal complications. An accurate diagnostic test is needed to... Background and aim: Intrahepatic cholestasis of pregnancy (ICP) is linked with increased risk of fetal complications. An accurate diagnostic test is needed to... |
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SubjectTerms | Adult Alanine Transaminase - blood Aspartate Aminotransferases - blood Bile Acids and Salts - blood Biomarkers - blood Chenodeoxycholic Acid - blood Cholestasis, Intrahepatic - blood Cholestasis, Intrahepatic - diagnosis Cholic Acid - blood Clinical Enzyme Tests Diagnostics Female Gastroenterology and Hepatology Humans Intrahepatic cholestasis Liver Function Tests Predictive Value of Tests Pregnancy Pregnancy Complications - blood Pregnancy Complications - diagnosis Reproducibility of Results Retrospective Studies Serum bile acids Transaminases Young Adult |
Title | Sensitivity and Specificity of Biochemical Tests for Diagnosis of Intrahepatic Cholestasis of Pregnancy |
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