STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases

• Published in: Frontiers in aging Vol. 3; p. 876785
• Main Authors: Collins, Helen E., Zhang, Dingguo, Chatham, John C.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 19.04.2022
• Subjects: Aging; calcium; cardiovascular disease; cell survival; neurodegeneration; orai; STIM; cardiovascular disease; STIM; calcium; cell survival; SOCE channels; neurodegeneration; orai

Tight spatiotemporal regulation of intracellular Ca 2+ plays a critical role in regulating diverse cellular functions including cell survival, metabolism, and transcription. As a result, eukaryotic cells have developed a wide variety of mechanisms for controlling Ca 2+ influx and efflux across the p...