c-di-GMP Homeostasis Is Critical for Heterocyst Development in Anabaena sp. PCC 7120

c-di-GMP is a ubiquitous bacterial signal regulating various physiological process. PCC 7120 ( ) is a filamentous cyanobacterium able to form regularly-spaced heterocysts for nitrogen fixation, in response to combined-nitrogen deprivation in 24h. possesses 16 genes encoding proteins for c-di-GMP met...

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Published inFrontiers in microbiology Vol. 12; p. 793336
Main Authors Huang, Min, Zhang, Ju-Yuan, Zeng, Xiaoli, Zhang, Cheng-Cai
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 03.12.2021
Subjects
c-di-GMP
cyanobacteria
homeostasis
Microbiology
nitrogen fixation
signal transduction
homeostasis
c-di-GMP
nitrogen fixation
signal transduction
cyanobacteria
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Abstract c-di-GMP is a ubiquitous bacterial signal regulating various physiological process. PCC 7120 ( ) is a filamentous cyanobacterium able to form regularly-spaced heterocysts for nitrogen fixation, in response to combined-nitrogen deprivation in 24h. possesses 16 genes encoding proteins for c-di-GMP metabolism, and their functions are poorly characterized, except ( ) whose deletion causes a decrease in heterocyst frequency 48h after nitrogen starvation. We demonstrated here that c-di-GMP levels increased significantly in after combined-nitrogen starvation. By inactivating each of the 16 genes, we found that the deletion of 5 ( ) led to an increase of heterocyst frequency 24h after nitrogen stepdown. A double mutant had an additive effect over the single mutants in regulating heterocyst frequency, indicating that the two genes acted at different time points for heterocyst spacing. Biochemical and genetic data further showed that the functions of CdgSH and CdgS in the setup or maintenance of heterocyst frequency depended on their opposing effects on the intracellular levels of c-di-GMP. Finally, we demonstrated that heterocyst differentiation was completely inhibited when c-di-GMP levels became too high or too low. Together, these results indicate that the homeostasis of c-di-GMP level is important for heterocyst differentiation in .
AbstractList c-di-GMP is a ubiquitous bacterial signal regulating various physiological process. PCC 7120 ( ) is a filamentous cyanobacterium able to form regularly-spaced heterocysts for nitrogen fixation, in response to combined-nitrogen deprivation in 24h. possesses 16 genes encoding proteins for c-di-GMP metabolism, and their functions are poorly characterized, except ( ) whose deletion causes a decrease in heterocyst frequency 48h after nitrogen starvation. We demonstrated here that c-di-GMP levels increased significantly in after combined-nitrogen starvation. By inactivating each of the 16 genes, we found that the deletion of 5 ( ) led to an increase of heterocyst frequency 24h after nitrogen stepdown. A double mutant had an additive effect over the single mutants in regulating heterocyst frequency, indicating that the two genes acted at different time points for heterocyst spacing. Biochemical and genetic data further showed that the functions of CdgSH and CdgS in the setup or maintenance of heterocyst frequency depended on their opposing effects on the intracellular levels of c-di-GMP. Finally, we demonstrated that heterocyst differentiation was completely inhibited when c-di-GMP levels became too high or too low. Together, these results indicate that the homeostasis of c-di-GMP level is important for heterocyst differentiation in .
c-di-GMP is a ubiquitous bacterial signal regulating various physiological process. Anabaena PCC 7120 ( Anabaena ) is a filamentous cyanobacterium able to form regularly-spaced heterocysts for nitrogen fixation, in response to combined-nitrogen deprivation in 24h. Anabaena possesses 16 genes encoding proteins for c-di-GMP metabolism, and their functions are poorly characterized, except all2874 ( cdgS ) whose deletion causes a decrease in heterocyst frequency 48h after nitrogen starvation. We demonstrated here that c-di-GMP levels increased significantly in Anabaena after combined-nitrogen starvation. By inactivating each of the 16 genes, we found that the deletion of all117 5 ( cdgSH ) led to an increase of heterocyst frequency 24h after nitrogen stepdown. A double mutant ΔcdgSHΔcdgS had an additive effect over the single mutants in regulating heterocyst frequency, indicating that the two genes acted at different time points for heterocyst spacing. Biochemical and genetic data further showed that the functions of CdgSH and CdgS in the setup or maintenance of heterocyst frequency depended on their opposing effects on the intracellular levels of c-di-GMP. Finally, we demonstrated that heterocyst differentiation was completely inhibited when c-di-GMP levels became too high or too low. Together, these results indicate that the homeostasis of c-di-GMP level is important for heterocyst differentiation in Anabaena .
c-di-GMP is a ubiquitous bacterial signal regulating various physiological process. Anabaena PCC 7120 (Anabaena) is a filamentous cyanobacterium able to form regularly-spaced heterocysts for nitrogen fixation, in response to combined-nitrogen deprivation in 24h. Anabaena possesses 16 genes encoding proteins for c-di-GMP metabolism, and their functions are poorly characterized, except all2874 (cdgS) whose deletion causes a decrease in heterocyst frequency 48h after nitrogen starvation. We demonstrated here that c-di-GMP levels increased significantly in Anabaena after combined-nitrogen starvation. By inactivating each of the 16 genes, we found that the deletion of all1175 (cdgSH) led to an increase of heterocyst frequency 24h after nitrogen stepdown. A double mutant ΔcdgSHΔcdgS had an additive effect over the single mutants in regulating heterocyst frequency, indicating that the two genes acted at different time points for heterocyst spacing. Biochemical and genetic data further showed that the functions of CdgSH and CdgS in the setup or maintenance of heterocyst frequency depended on their opposing effects on the intracellular levels of c-di-GMP. Finally, we demonstrated that heterocyst differentiation was completely inhibited when c-di-GMP levels became too high or too low. Together, these results indicate that the homeostasis of c-di-GMP level is important for heterocyst differentiation in Anabaena.
Author Zhang, Cheng-Cai
Zeng, Xiaoli
Huang, Min
Zhang, Ju-Yuan
AuthorAffiliation 2 College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences , Beijing , China
3 Institut AMU-WUT, Aix-Marseille University and Wuhan University of Technology , Wuhan , China
1 State Key Laboratory of Freshwater Ecology and Biotechnology, Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan , China
4 Innovation Academy for Seed Design, Chinese Academy of Sciences , Beijing , China
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Keywords homeostasis
c-di-GMP
nitrogen fixation
signal transduction
cyanobacteria
Language English
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Snippet c-di-GMP is a ubiquitous bacterial signal regulating various physiological process. PCC 7120 ( ) is a filamentous cyanobacterium able to form regularly-spaced...
c-di-GMP is a ubiquitous bacterial signal regulating various physiological process. Anabaena PCC 7120 ( Anabaena ) is a filamentous cyanobacterium able to form...
c-di-GMP is a ubiquitous bacterial signal regulating various physiological process. Anabaena PCC 7120 (Anabaena) is a filamentous cyanobacterium able to form...
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StartPage 793336
SubjectTerms c-di-GMP
cyanobacteria
homeostasis
Microbiology
nitrogen fixation
signal transduction
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Title c-di-GMP Homeostasis Is Critical for Heterocyst Development in Anabaena sp. PCC 7120
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