Knockout of IL-6 mitigates cold water-immersion restraint stress-induced intestinal epithelial injury and apoptosis

• Published in: Frontiers in immunology Vol. 13; p. 936689
• Main Authors: Zhang, Yuan, Duan, Chujun, Wu, Shuwen, Ma, Jingchang, Liu, Yongming, Li, Wenpeng, Wang, Tingting, Yang, Lu, Cheng, Kun, Zhuang, Ran
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 25.11.2022
• Subjects: Animals; apoptosis; Apoptosis - genetics; Dehydration; distress; IL-6; Immunology; Interleukin-6 - genetics; intestinal mucosal barrier; KO mice; Mice; Mice, Knockout; Water; distress; apoptosis; KO mice; intestinal mucosal barrier; IL-6

Interleukin-6 (IL-6) is essential for maintaining intestinal epithelial homeostasis. Although cold water-immersion restraint (CWIR) stress is commonly used to induce in vivo gastric injury, it also affects intestinal epithelial permeability. Although IL-6 is increased in response to acute physiologi...