Research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinoma

• Published in: Frontiers in oncology Vol. 12; p. 1063423
• Main Authors: Xu, Yiwei, Hao, Xiaodong, Ren, Yidan, Xu, Qinchen, Liu, Xiaoyan, Song, Shuliang, Wang, Yunshan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 06.01.2023
• Subjects: hepatocellular carcinoma; immune regulation; immunotherapy; lactate metabolism; lactylation; Oncology; lactate metabolism; lactylation; hepatocellular carcinoma; immune regulation; immunotherapy

Tumors meet their energy, biosynthesis, and redox demands through metabolic reprogramming. This metabolic abnormality results in elevated levels of metabolites, particularly lactate, in the tumor microenvironment. Immune cell reprogramming and cellular plasticity mediated by lactate and lactylation...