Research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinoma

Tumors meet their energy, biosynthesis, and redox demands through metabolic reprogramming. This metabolic abnormality results in elevated levels of metabolites, particularly lactate, in the tumor microenvironment. Immune cell reprogramming and cellular plasticity mediated by lactate and lactylation...

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Published inFrontiers in oncology Vol. 12; p. 1063423
Main Authors Xu, Yiwei, Hao, Xiaodong, Ren, Yidan, Xu, Qinchen, Liu, Xiaoyan, Song, Shuliang, Wang, Yunshan
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 06.01.2023
Subjects
hepatocellular carcinoma
immune regulation
immunotherapy
lactate metabolism
lactylation
Oncology
lactate metabolism
lactylation
hepatocellular carcinoma
immune regulation
immunotherapy
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Abstract Tumors meet their energy, biosynthesis, and redox demands through metabolic reprogramming. This metabolic abnormality results in elevated levels of metabolites, particularly lactate, in the tumor microenvironment. Immune cell reprogramming and cellular plasticity mediated by lactate and lactylation increase immunosuppression in the tumor microenvironment and are emerging as key factors in regulating tumor development, metastasis, and the effectiveness of immunotherapies such as immune checkpoint inhibitors. Reprogramming of glucose metabolism and the “Warburg effect” in hepatocellular carcinoma (HCC) lead to the massive production and accumulation of lactate, so lactate modification in tumor tissue is likely to be abnormal as well. This article reviews the immune regulation of abnormal lactate metabolism and lactate modification in hepatocellular carcinoma and the therapeutic strategy of targeting lactate-immunotherapy, which will help to better guide the medication and treatment of patients with hepatocellular carcinoma.
AbstractList Tumors meet their energy, biosynthesis, and redox demands through metabolic reprogramming. This metabolic abnormality results in elevated levels of metabolites, particularly lactate, in the tumor microenvironment. Immune cell reprogramming and cellular plasticity mediated by lactate and lactylation increase immunosuppression in the tumor microenvironment and are emerging as key factors in regulating tumor development, metastasis, and the effectiveness of immunotherapies such as immune checkpoint inhibitors. Reprogramming of glucose metabolism and the "Warburg effect" in hepatocellular carcinoma (HCC) lead to the massive production and accumulation of lactate, so lactate modification in tumor tissue is likely to be abnormal as well. This article reviews the immune regulation of abnormal lactate metabolism and lactate modification in hepatocellular carcinoma and the therapeutic strategy of targeting lactate-immunotherapy, which will help to better guide the medication and treatment of patients with hepatocellular carcinoma.Tumors meet their energy, biosynthesis, and redox demands through metabolic reprogramming. This metabolic abnormality results in elevated levels of metabolites, particularly lactate, in the tumor microenvironment. Immune cell reprogramming and cellular plasticity mediated by lactate and lactylation increase immunosuppression in the tumor microenvironment and are emerging as key factors in regulating tumor development, metastasis, and the effectiveness of immunotherapies such as immune checkpoint inhibitors. Reprogramming of glucose metabolism and the "Warburg effect" in hepatocellular carcinoma (HCC) lead to the massive production and accumulation of lactate, so lactate modification in tumor tissue is likely to be abnormal as well. This article reviews the immune regulation of abnormal lactate metabolism and lactate modification in hepatocellular carcinoma and the therapeutic strategy of targeting lactate-immunotherapy, which will help to better guide the medication and treatment of patients with hepatocellular carcinoma.
Tumors meet their energy, biosynthesis, and redox demands through metabolic reprogramming. This metabolic abnormality results in elevated levels of metabolites, particularly lactate, in the tumor microenvironment. Immune cell reprogramming and cellular plasticity mediated by lactate and lactylation increase immunosuppression in the tumor microenvironment and are emerging as key factors in regulating tumor development, metastasis, and the effectiveness of immunotherapies such as immune checkpoint inhibitors. Reprogramming of glucose metabolism and the “Warburg effect” in hepatocellular carcinoma (HCC) lead to the massive production and accumulation of lactate, so lactate modification in tumor tissue is likely to be abnormal as well. This article reviews the immune regulation of abnormal lactate metabolism and lactate modification in hepatocellular carcinoma and the therapeutic strategy of targeting lactate-immunotherapy, which will help to better guide the medication and treatment of patients with hepatocellular carcinoma.
Author Song, Shuliang
Ren, Yidan
Hao, Xiaodong
Xu, Qinchen
Liu, Xiaoyan
Wang, Yunshan
Xu, Yiwei
AuthorAffiliation 3 Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University , Jinan, Shandong , China
1 Marine College, Shandong University , Weihai , China
2 Department of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University , Jinan, Shandong , China
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Keywords lactate metabolism
lactylation
hepatocellular carcinoma
immune regulation
immunotherapy
Language English
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This article was submitted to Cancer Metabolism, a section of the journal Frontiers in Oncology
Reviewed by: Sweta Sikder, National Institutes of Health (NIH), United States; Amarshi Mukherjee, University of Alabama at Birmingham, United States
Edited by: Parames C. Sil, Bose Institute, India
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Snippet Tumors meet their energy, biosynthesis, and redox demands through metabolic reprogramming. This metabolic abnormality results in elevated levels of...
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SubjectTerms hepatocellular carcinoma
immune regulation
immunotherapy
lactate metabolism
lactylation
Oncology
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Title Research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinoma
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