HLA-DRB1 and –DQB1 Alleles, Haplotypes and Genotypes in Emirati Patients with Type 1 Diabetes Underscores the Benefits of Evaluating Understudied Populations

• Published in: Frontiers in genetics Vol. 13; p. 841879
• Main Authors: Al Yafei, Zain, Mack, Steven J., Alvares, Marion, Ali, Bassam R., Afandi, Bachar, Beshyah, Salem A., Sharma, Charu, Osman, Wael, Mirghani, Rajaa, Nasr, Amre, Al Remithi, Sareea, Al Jubeh, Jamal, Almawi, Wasim Y., AlKaabi, Juma, ElGhazali, Gehad
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 24.03.2022
• Subjects: Emiratis; ethnicity; Genetics; haplotypes; HLA; type 1 diabetes; haplotypes; type 1 diabetes; ethnicity; HLA; Emiratis

Background: HLA class II (DR and DQ) alleles and antigens have historically shown strong genetic predisposition to type 1 diabetes (T1D). This study evaluated the association of DRB1 and DQB1 alleles, genotypes, and haplotypes with T1D in United Arab Emirates. Materials and Methods: Study subjects c...