The oncogenic Golgi phosphoprotein 3 like overexpression is associated with cisplatin resistance in ovarian carcinoma and activating the NF-κB signaling pathway

• Published in: Journal of experimental & clinical cancer research Vol. 36; no. 1; pp. 137 - 12
• Main Authors: He, Shanyang, Niu, Gang, Shang, Jianhong, Deng, Yalan, Wan, Zhiyong, Zhang, Cai, You, Zeshan, Shen, Hongwei
• Format: Journal Article
• Language: English
• Published: England BioMed Central 04.10.2017; BMC
• Subjects: Animals; Cell Line, Tumor; Chemo-resistance; Cisplatin - pharmacology; Disease Models, Animal; Disease Progression; Drug Resistance, Neoplasm - genetics; Female; Gene Expression; Gene Expression Regulation, Neoplastic - drug effects; GOLPH3L; Humans; Mice; NF-kappa B - metabolism; Nuclear factor-κB (NF-κB) signaling; Ovarian cancer; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - mortality; Ovarian Neoplasms - pathology; Phosphoproteins - genetics; Prognosis; Signal Transduction - drug effects; Tumor Burden; Xenograft Model Antitumor Assays; Chemo-resistance; GOLPH3L; Nuclear factor-κB (NF-κB) signaling; Ovarian cancer

Chemo-resistance is a leading cause of tumor relapse and treatment failure in patients with ovarian cancer. The identification of effective strategies to overcome drug resistance will have a significant clinical impact on the disease. The protein and mRNA expression of GOLPH3L in ovarian cancer cell...